Entry
Name
ABC transporters - Hirundo rustica (Barn swallow)
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Hirundo rustica (Barn swallow) [GN:
hrt ]
Gene
120765074 ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641 ]
120761854 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
120756281 ABCA4; retinal-specific phospholipid-transporting ATPase ABCA4 [KO:K05644 ]
120760809 ABCA9; ATP-binding cassette sub-family A member 9 isoform X1 [KO:K05651 ]
120761006 ATP-binding cassette sub-family A member 9-like isoform X1 [KO:K05651 ]
120750465 ABCB10; ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
120762032 ABCB7; iron-sulfur clusters transporter ABCB7, mitochondrial [KO:K05662 ]
120760972 ABCC3; ATP-binding cassette sub-family C member 3 isoform X1 [KO:K05667 ]
120748867 ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673 ]
120757218 ABCC5; ATP-binding cassette sub-family C member 5 isoform X3 [KO:K05668 ]
120759732 ATP-binding cassette sub-family C member 6-like isoform X1 [KO:K05669 ]
120750750 ABCC10; ATP-binding cassette sub-family C member 10 isoform X1 [KO:K05674 ]
120754050 ABCC8; ATP-binding cassette sub-family C member 8 isoform X1 [KO:K05032 ]
120752400 ABCC9; ATP-binding cassette sub-family C member 9 isoform X2 [KO:K05033 ]
120748516 ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679 ]
120762644 ABCG4; ATP-binding cassette sub-family G member 4 isoform X1 [KO:K05680 ]
120752872 ABCG2; broad substrate specificity ATP-binding cassette transporter ABCG2 [KO:K05681 ]
120756120 broad substrate specificity ATP-binding cassette transporter ABCG2-like [KO:K05681 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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