KEGG   PATHWAY: hshi00010
Entry
hshi00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Halobacillus shinanisalinarum
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
hshi00010  Glycolysis / Gluconeogenesis
hshi00010

Module
hshi_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hshi00010]
Other DBs
GO: 0006096 0006094
Organism
Halobacillus shinanisalinarum [GN:hshi]
Gene
MUO14_06490  ROK family transcriptional regulator [KO:K25026] [EC:2.7.1.2]
MUO14_15425  ROK family protein [KO:K25026] [EC:2.7.1.2]
MUO14_04440  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
MUO14_03880  pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
MUO14_04575  glpX; class II fructose-bisphosphatase [KO:K02446] [EC:3.1.3.11]
MUO14_08625  glpX; class II fructose-bisphosphatase [KO:K02446] [EC:3.1.3.11]
MUO14_15845  fructose bisphosphate aldolase [KO:K01623] [EC:4.1.2.13]
MUO14_08645  fba; class II fructose-1,6-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
MUO14_05060  tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
MUO14_05070  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
MUO14_03810  glyceraldehyde-3-phosphate dehydrogenase [KO:K00150] [EC:1.2.1.59]
MUO14_00430  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
MUO14_05050  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
MUO14_03875  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
MUO14_07140  ppdK; pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
MUO14_21945  pdhA; pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha [KO:K00161] [EC:1.2.4.1]
MUO14_16385  alpha-ketoacid dehydrogenase subunit beta [KO:K00162] [EC:1.2.4.1]
MUO14_21950  alpha-ketoacid dehydrogenase subunit beta [KO:K00162] [EC:1.2.4.1]
MUO14_16390  2-oxo acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
MUO14_21955  2-oxo acid dehydrogenase subunit E2 [KO:K00627] [EC:2.3.1.12]
MUO14_01360  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MUO14_21960  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MUO14_12855  glutathione-dependent formaldehyde dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
MUO14_01250  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
MUO14_07530  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
MUO14_08815  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
MUO14_16755  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
MUO14_17645  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
MUO14_18615  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
MUO14_10205  aldehyde dehydrogenase family protein [KO:K00138] [EC:1.2.1.-]
MUO14_00175  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
MUO14_11930  acsA; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
MUO14_14250  acsA; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
MUO14_19120  acyl--CoA ligase [KO:K01895] [EC:6.2.1.1]
MUO14_05660  phospho-sugar mutase [KO:K01835] [EC:5.4.2.2]
MUO14_04335  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
MUO14_06210  6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
MUO14_06440  6-phospho-beta-glucosidase [KO:K01222] [EC:3.2.1.86]
MUO14_06445  glycoside hydrolase family 1 protein [KO:K01223] [EC:3.2.1.86]
MUO14_07450  glycoside hydrolase family 1 protein [KO:K01223] [EC:3.2.1.86]
MUO14_09885  PTS glucose transporter subunit IIA [KO:K02777] [EC:2.7.1.-]
MUO14_10150  PTS glucose transporter subunit IIA [KO:K02777] [EC:2.7.1.-]
MUO14_19535  ptsG; glucose-specific PTS transporter subunit IIBC [KO:K20118] [EC:2.7.1.199]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
hshi00020  Citrate cycle (TCA cycle)
hshi00030  Pentose phosphate pathway
hshi00500  Starch and sucrose metabolism
hshi00620  Pyruvate metabolism
hshi00640  Propanoate metabolism
hshi00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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