KEGG   PATHWAY: hyn00030
Entry
hyn00030                    Pathway                                
Name
Pentose phosphate pathway - Hydrogenophaga sp. BPS33
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
hyn00030  Pentose phosphate pathway
hyn00030

Module
hyn_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:hyn00030]
hyn_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:hyn00030]
hyn_M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:hyn00030]
Other DBs
GO: 0006098
Organism
Hydrogenophaga sp. BPS33 [GN:hyn]
Gene
F9K07_20240  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
F9K07_20220  zwf; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
F9K07_20225  pgl; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
F9K07_06560  lactonase family protein [KO:K07404] [EC:3.1.1.31]
F9K07_26995  ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
F9K07_29020  tkt; transketolase [KO:K00615] [EC:2.2.1.1]
F9K07_25550  tal; transaldolase [KO:K00616] [EC:2.2.1.2]
F9K07_16480  rpiA; ribose-5-phosphate isomerase RpiA [KO:K01807] [EC:5.3.1.6]
F9K07_00905  phnN; phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN [KO:K05774] [EC:2.7.4.23]
F9K07_20320  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
F9K07_20230  phosphogluconate dehydratase [KO:K01690] [EC:4.2.1.12]
F9K07_20235  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
F9K07_01875  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_07490  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_07495  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_00590  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_22935  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_09250  SMP-30/gluconolactonase/LRE family protein [KO:K01053] [EC:3.1.1.17]
F9K07_12330  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
F9K07_16955  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
F9K07_08585  glycerate kinase [KO:K11529] [EC:2.7.1.165]
F9K07_03295  fructose-bisphosphate aldolase class II [KO:K01624] [EC:4.1.2.13]
F9K07_22550  class 1 fructose-bisphosphatase [KO:K03841] [EC:3.1.3.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
hyn00010  Glycolysis / Gluconeogenesis
hyn00040  Pentose and glucuronate interconversions
hyn00052  Galactose metabolism
hyn00230  Purine metabolism
hyn00240  Pyrimidine metabolism
hyn00340  Histidine metabolism
hyn00630  Glyoxylate and dicarboxylate metabolism
hyn00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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