KEGG   PATHWAY: lpil03410
Entry
lpil03410                   Pathway                                
Name
Base excision repair - Limnochorda pilosa
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
lpil03410  Base excision repair
lpil03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Limnochorda pilosa [GN:lpil]
Gene
LIP_0679  endonuclease III [KO:K10773] [EC:3.2.2.- 4.2.99.18]
LIP_3219  3-methyladenine DNA glycosylase [KO:K03652] [EC:3.2.2.21]
LIP_1498  formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
LIP_3497  formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
LIP_0335  hypothetical protein [KO:K01247] [EC:3.2.2.21]
LIP_1110  uracil-DNA glycosylase [KO:K21929] [EC:3.2.2.27]
LIP_1763  DNA polymerase [KO:K21929] [EC:3.2.2.27]
LIP_3007  endonuclease IV [KO:K01151] [EC:3.1.21.2]
LIP_1497  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
LIP_2634  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
LIP_2812  NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
LinkDB

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