KEGG   PATHWAY: mcha00061
Entry
mcha00061                   Pathway                                
Name
Fatty acid biosynthesis - Momordica charantia (bitter melon)
Class
Metabolism; Lipid metabolism
Pathway map
mcha00061  Fatty acid biosynthesis
mcha00061

Module
mcha_M00082  Fatty acid biosynthesis, initiation [PATH:mcha00061]
mcha_M00083  Fatty acid biosynthesis, elongation [PATH:mcha00061]
mcha_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:mcha00061]
Other DBs
GO: 0006633
Organism
Momordica charantia (bitter melon) [GN:mcha]
Gene
111011862  acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111016370  acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic-like [KO:K01962] [EC:6.4.1.2 2.1.3.15]
111019420  acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic [KO:K01962] [EC:6.4.1.2 2.1.3.15]
111014125  biotin carboxyl carrier protein of acetyl-CoA carboxylase, chloroplastic-like [KO:K02160]
111013127  biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic-like [KO:K02160]
111017801  biotin carboxylase 1, chloroplastic [KO:K01961] [EC:6.4.1.2 6.3.4.14]
36165242  accD; acetyl-CoA carboxylase beta subunit [KO:K01963] [EC:6.4.1.2 2.1.3.15]
111020569  malonate--CoA ligase isoform X1 [KO:K18660] [EC:6.2.1.76 6.2.1.-]
111022022  uncharacterized protein LOC111022022 [KO:K00645] [EC:2.3.1.39]
111023344  3-oxoacyl-[acyl-carrier-protein] synthase 3 A, chloroplastic [KO:K00648] [EC:2.3.1.180]
111010743  3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic [KO:K09458] [EC:2.3.1.179]
111021861  3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like isoform X1 [KO:K09458] [EC:2.3.1.179]
111018117  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform X1 [KO:K09458] [EC:2.3.1.179]
111016524  3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic-like [KO:K09458] [EC:2.3.1.179]
111004877  3-oxoacyl-[acyl-carrier-protein] reductase 4 [KO:K00059] [EC:1.1.1.100]
111022892  NADPH-dependent aldehyde reductase-like protein, chloroplastic isoform X1 [KO:K00059] [EC:1.1.1.100]
111008425  uncharacterized protein LOC111008425 [KO:K02372] [EC:4.2.1.59]
111021238  enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic-like [KO:K00208] [EC:1.3.1.9 1.3.1.10]
111021451  enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic [KO:K00208] [EC:1.3.1.9 1.3.1.10]
111023547  enoyl-[acyl-carrier-protein] reductase, mitochondrial [KO:K07512] [EC:1.3.1.- 1.3.1.38]
111012889  palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21]
111025297  palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21]
111014514  palmitoyl-acyl carrier protein thioesterase, chloroplastic-like [KO:K10781] [EC:3.1.2.14 3.1.2.21]
111016652  oleoyl-acyl carrier protein thioesterase 1, chloroplastic-like [KO:K10782] [EC:3.1.2.14]
111004796  acyl-[acyl-carrier-protein] desaturase, chloroplastic [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
111014172  stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic-like [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
111009493  long chain acyl-CoA synthetase 6, peroxisomal-like [KO:K01897] [EC:6.2.1.3]
111016178  probable acyl-activating enzyme 16, chloroplastic [KO:K01897] [EC:6.2.1.3]
111015238  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
111023830  long chain acyl-CoA synthetase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
111017256  long chain acyl-CoA synthetase 2 isoform X1 [KO:K01897] [EC:6.2.1.3]
111007680  long chain acyl-CoA synthetase 8 [KO:K01897] [EC:6.2.1.3]
111022123  long chain acyl-CoA synthetase 9, chloroplastic [KO:K01897] [EC:6.2.1.3]
111008230  long chain acyl-CoA synthetase 4-like [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
mcha00020  Citrate cycle (TCA cycle)
mcha00062  Fatty acid elongation
mcha00071  Fatty acid degradation
mcha00410  beta-Alanine metabolism
mcha00561  Glycerolipid metabolism
mcha00564  Glycerophospholipid metabolism
mcha00620  Pyruvate metabolism
mcha00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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