KEGG PATHWAY: mcs00260

PATHWAY: mcs00260

Entry

mcs00260                    Pathway

Name

Glycine, serine and threonine metabolism - Moraxella catarrhalis 25240

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mcs00260

Glycine, serine and threonine metabolism

Module

mcs_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mcs00260]

mcs_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mcs00260]

mcs_M00621

Glycine cleavage system [PATH:mcs00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Moraxella catarrhalis 25240 [GN:mcs]

Gene

DR90_1333

aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

DR90_677

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

DR90_1421

ACT domain protein [KO:K00003] [EC:1.1.1.3]

DR90_178

phosphotransferase enzyme family protein [KO:K02204] [EC:2.7.1.39]

DR90_86

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

DR90_325

glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]

DR90_412

putative 2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]

DR90_1054

histidine phosphatase super family protein [KO:K01834] [EC:5.4.2.11]

DR90_836

gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

DR90_1641

acetohydroxy acid isomeroreductase, catalytic domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

DR90_710

serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

DR90_1484

serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]

DR90_638

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

DR90_640

gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

DR90_10

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

DR90_639

gcvH; glycine cleavage system H protein [KO:K02437]

DR90_1607

pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

DR90_856

L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

DR90_1205

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

DR90_505

trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

DR90_504

trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

DR90_1548

dat; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]

DR90_1539

ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721