KEGG   PATHWAY: mdo00591
Entry
mdo00591                    Pathway                                
Name
Linoleic acid metabolism - Monodelphis domestica (gray short-tailed opossum)
Class
Metabolism; Lipid metabolism
Pathway map
mdo00591  Linoleic acid metabolism
mdo00591

Other DBs
GO: 0043651
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100009945  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
100027378  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
100027467  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
100027397  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
100027418  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
100024666  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
100023771  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
100010093  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
100026162  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
103099972  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
103106467  basic phospholipase A2 Sms-N6-like [KO:K01047] [EC:3.1.1.4]
103094068  PROCA1; protein interacting with cyclin A1 [KO:K01047] [EC:3.1.1.4]
103105270  basic phospholipase A2 homolog [KO:K01047] [EC:3.1.1.4]
100024859  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
100009808  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
100620032  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
100029998  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100029983  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
100030037  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100016178  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
768082  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100013657  uncharacterized LOC100013657 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100015976  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
100029908  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100023204  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100023235  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100023149  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100026569  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100026598  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100026637  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100028608  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100020348  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100026618  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
100031971  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031902  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031907  cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031980  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031984  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031975  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031914  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100031960  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100015828  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
100013238  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010783  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100013114  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
100010698  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010745  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
100010820  cytochrome P450 3A4-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
mdo00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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