KEGG   PATHWAY: mpw00260
Entry
mpw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Myroides profundi
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mpw00260  Glycine, serine and threonine metabolism
mpw00260

Module
mpw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mpw00260]
mpw_M00621  Glycine cleavage system [PATH:mpw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Myroides profundi [GN:mpw]
Gene
MPR_0197  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MPR_0752  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MPR_0304  bifunctional aspartokinase / homoserine dehydrogenase 1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
MPR_1490  bifunctional aspartokinase / homoserine dehydrogenase 1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
MPR_0267  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MPR_1491  homoserine kinase [KO:K00872] [EC:2.7.1.39]
MPR_1492  threonine synthase [KO:K01733] [EC:4.2.3.1]
MPR_1819  threonine aldolase [KO:K01620] [EC:4.1.2.48]
MPR_2637  threonine aldolase [KO:K01620] [EC:4.1.2.48]
MPR_1649  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MPR_1480  glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MPR_0431  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
MPR_0946  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MPR_1907  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MPR_3591  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MPR_0945  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MPR_0436  short-chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MPR_1193  7-keto-8-aminopelargonate synthetase or related enzyme [KO:K00639] [EC:2.3.1.29]
MPR_3519  7-keto-8-aminopelargonate synthetase or related enzyme [KO:K00639] [EC:2.3.1.29]
MPR_3184  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MPR_1042  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MPR_0775  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
MPR_0826  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
MPR_1814  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
MPR_0537  glycine cleavage system H protein [KO:K02437]
MPR_2980  CDP-diacylglycerol---serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
MPR_0888  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MPR_1054  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
MPR_0900  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MPR_2397  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
MPR_0208  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
MPR_0209  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
MPR_2797  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mpw00010  Glycolysis / Gluconeogenesis
mpw00020  Citrate cycle (TCA cycle)
mpw00230  Purine metabolism
mpw00250  Alanine, aspartate and glutamate metabolism
mpw00270  Cysteine and methionine metabolism
mpw00290  Valine, leucine and isoleucine biosynthesis
mpw00300  Lysine biosynthesis
mpw00330  Arginine and proline metabolism
mpw00460  Cyanoamino acid metabolism
mpw00470  D-Amino acid metabolism
mpw00564  Glycerophospholipid metabolism
mpw00620  Pyruvate metabolism
mpw00630  Glyoxylate and dicarboxylate metabolism
mpw00640  Propanoate metabolism
mpw00680  Methane metabolism
mpw00860  Porphyrin metabolism
mpw00920  Sulfur metabolism
KO pathway
ko00260   
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