KEGG   PATHWAY: msm00730
Entry
msm00730                    Pathway                                
Name
Thiamine metabolism - Mycolicibacterium smegmatis MC2 155
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
msm00730  Thiamine metabolism
msm00730

Other DBs
GO: 0006772
Organism
Mycolicibacterium smegmatis MC2 155 [GN:msm]
Gene
MSMEG_0826  thiC; thiamine biosynthesis protein ThiC [KO:K03147] [EC:4.1.99.17]
MSMEG_0149  ThiC family protein [KO:K03147] [EC:4.1.99.17]
MSMEG_0825  thiD; phosphomethylpyrimidine kinase [KO:K00941] [EC:2.7.1.49 2.7.4.7]
MSMEG_2357  cysteine desulfurase [KO:K04487] [EC:2.8.1.7]
MSMEG_1242  iscS; cysteine desulfurase IscS [KO:K04487] [EC:2.8.1.7]
MSMEG_0791  thiO; glycine oxidase ThiO [KO:K03153] [EC:1.4.3.19]
MSMEG_2776  dxs; 1-deoxy-D-xylulose-5-phosphate synthase [KO:K01662] [EC:2.2.1.7]
MSMEG_0793  thiG; thiazole biosynthesis protein ThiG [KO:K03149] [EC:2.8.1.10]
MSMEG_0789  thiE; thiamine-phosphate pyrophosphorylase [KO:K00788] [EC:2.5.1.3]
MSMEG_2398  thiL; thiamine-monophosphate kinase [KO:K00946] [EC:2.7.4.16]
MSMEG_1889  putative ribosome small subunit-dependent GTPase RsgA [KO:K06949] [EC:3.6.1.- 3.1.3.100]
MSMEG_1012  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
MSMEG_2292  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
MSMEG_1484  adenylate kinase [KO:K00939] [EC:2.7.4.3]
MSMEG_3478  tena/thi-4 family protein [KO:K03707] [EC:3.5.99.2]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
msm00010  Glycolysis / Gluconeogenesis
msm00230  Purine metabolism
msm00260  Glycine, serine and threonine metabolism
msm00270  Cysteine and methionine metabolism
msm00400  Phenylalanine, tyrosine and tryptophan biosynthesis
msm00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

DBGET integrated database retrieval system