KEGG   PATHWAY: nmg00260
Entry
nmg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Natrialba magadii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nmg00260  Glycine, serine and threonine metabolism
nmg00260

Module
nmg_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nmg00260]
nmg_M00621  Glycine cleavage system [PATH:nmg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Natrialba magadii [GN:nmg]
Gene
Nmag_1935  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
Nmag_0032  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Nmag_2515  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Nmag_1251  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
Nmag_4007  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01733] [EC:4.2.3.1]
Nmag_1424  thrC5; threonine synthase [KO:K01733] [EC:4.2.3.1]
Nmag_1068  thrC3; threonine synthase [KO:K01733] [EC:4.2.3.1]
Nmag_0830  thrC2; threonine synthase [KO:K01733] [EC:4.2.3.1]
Nmag_1755  thrC1; threonine synthase [KO:K01733] [EC:4.2.3.1]
Nmag_1781  ltaE; threonine aldolase [KO:K01620] [EC:4.1.2.48]
Nmag_3305  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Nmag_0019  aminotransferase class V (serine--pyruvate aminotransferase / alanine--glyoxylate aminotransferase) [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Nmag_0806  DUF4147 domain protein [KO:K11529] [EC:2.7.1.165]
Nmag_2266  gpmI; phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type [KO:K15633] [EC:5.4.2.12]
Nmag_1887  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Nmag_1886  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Nmag_2893  amine oxidase [KO:K00274] [EC:1.4.3.4]
Nmag_0397  gcvP1; glycine cleavage system protein P alpha subunit [KO:K00282] [EC:1.4.4.2]
Nmag_0396  gcvP2; glycine cleavage system protein P beta subunit [KO:K00283] [EC:1.4.4.2]
Nmag_1501  homolog to glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
Nmag_0716  gcvT1; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
Nmag_1665  lpdA1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
Nmag_0717  gcvH; glycine cleavage system protein H [KO:K02437]
Nmag_2632  sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Nmag_1323  soxA; sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Nmag_1099  metB; cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase) [KO:K01758] [EC:4.4.1.1]
Nmag_3767  ilvA2; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Nmag_1915  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Nmag_1474  ilvA1; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
Nmag_2816  trpA; tryptophan synthase alpha subunit [KO:K01695] [EC:4.2.1.20]
Nmag_2817  trpB1; tryptophan synthase beta subunit [KO:K01696] [EC:4.2.1.20]
Nmag_2544  trpB2; tryptophan synthase beta subunit [KO:K01696] [EC:4.2.1.20]
Nmag_3950  pyridoxal phosphate-dependent aminotransferase [KO:K00836] [EC:2.6.1.76]
Nmag_3784  pyridoxal phosphate-dependent aminotransferase [KO:K00836] [EC:2.6.1.76]
Nmag_3760  peptidase M24 family protein (homolog to ectoine hydrolase) [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nmg00010  Glycolysis / Gluconeogenesis
nmg00020  Citrate cycle (TCA cycle)
nmg00230  Purine metabolism
nmg00250  Alanine, aspartate and glutamate metabolism
nmg00270  Cysteine and methionine metabolism
nmg00290  Valine, leucine and isoleucine biosynthesis
nmg00300  Lysine biosynthesis
nmg00330  Arginine and proline metabolism
nmg00460  Cyanoamino acid metabolism
nmg00470  D-Amino acid metabolism
nmg00564  Glycerophospholipid metabolism
nmg00620  Pyruvate metabolism
nmg00630  Glyoxylate and dicarboxylate metabolism
nmg00640  Propanoate metabolism
nmg00680  Methane metabolism
nmg00860  Porphyrin metabolism
nmg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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