KEGG   PATHWAY: nnu04144
Entry
nnu04144                    Pathway                                
Name
Endocytosis - Nelumbo nucifera (sacred lotus)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
nnu04144  Endocytosis
nnu04144

Other DBs
GO: 0006897
Organism
Nelumbo nucifera (sacred lotus) [GN:nnu]
Gene
104593435  putative phosphatidylinositol 4-phosphate 5-kinase 11 [KO:K00889] [EC:2.7.1.68]
104604569  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
104606056  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
104587071  phosphatidylinositol 4-phosphate 5-kinase 8 [KO:K00889] [EC:2.7.1.68]
104587332  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
104608461  phosphatidylinositol 4-phosphate 5-kinase 7-like [KO:K00889] [EC:2.7.1.68]
104611328  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
104608548  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
104589944  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
104592439  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
104595387  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
104598883  phospholipase D zeta 1 [KO:K01115] [EC:3.1.4.4]
104596208  phospholipase D beta 2-like [KO:K01115] [EC:3.1.4.4]
104600747  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
104603678  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
104604314  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
104613327  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
104608338  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
104608337  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
104608339  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
104589011  phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
104613359  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
104588555  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
104610181  dynamin-2A [KO:K01528] [EC:3.6.5.5]
104594936  clathrin heavy chain 2 [KO:K04646]
104602563  clathrin heavy chain 1-like [KO:K04646]
104587454  AP-2 complex subunit alpha-1-like [KO:K11824]
104612519  AP-2 complex subunit alpha-1-like [KO:K11824]
104606469  AP-2 complex subunit mu-like [KO:K11826]
104610374  AP-2 complex subunit mu [KO:K11826]
104605339  AP-2 complex subunit sigma [KO:K11827]
104605574  AP-2 complex subunit sigma-like [KO:K11827]
104594551  epsin-3 [KO:K12471]
104601016  epsin-3-like [KO:K12471]
104604450  clathrin interactor EPSIN 1-like [KO:K12471]
104602886  epsin-3 [KO:K12471]
104605283  clathrin interactor EPSIN 2 [KO:K12471]
104588220  clathrin interactor EPSIN 1-like [KO:K12471]
104603781  actin cytoskeleton-regulatory complex protein PAN1 [KO:K12472]
104606815  epidermal growth factor receptor substrate 15-like [KO:K12472]
104604240  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic [KO:K19366]
104592820  actin-related protein 2 [KO:K17260]
104591563  actin-related protein 3 [KO:K18584]
104608427  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
104609009  actin-related protein 2/3 complex subunit 1A [KO:K05757]
104600949  actin-related protein 2/3 complex subunit 2B [KO:K05758]
104599825  actin-related protein 2/3 complex subunit 2A [KO:K05758]
104589478  actin-related protein 2/3 complex subunit 3 [KO:K05756]
104590316  actin-related protein 2/3 complex subunit 4 [KO:K05755]
104610465  actin-related protein 2/3 complex subunit 5A-like [KO:K05754]
104598438  actin-related protein 2/3 complex subunit 5A [KO:K05754]
104603897  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
104594972  heat shock cognate 70 kDa protein 2-like [KO:K03283]
104594575  heat shock cognate 70 kDa protein 2-like [KO:K03283]
104594564  heat shock cognate 70 kDa protein 2 [KO:K03283]
104603244  heat shock 70 kDa protein-like [KO:K03283]
104609134  heat shock 70 kDa protein [KO:K03283]
104609133  heat shock 70 kDa protein-like [KO:K03283]
104586952  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
104586953  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
104611840  WASH complex subunit SWIP-like [KO:K18465]
104591878  WASH complex subunit strumpellin homolog [KO:K18464]
104591933  WASH complex subunit CCDC53-like [KO:K18463]
104598969  F-actin-capping protein subunit alpha [KO:K10364]
104599993  probable F-actin-capping protein subunit beta [KO:K10365]
104587413  probable F-actin-capping protein subunit beta [KO:K10365]
104601540  vacuolar protein sorting-associated protein 29 [KO:K18467]
104586763  vacuolar protein sorting-associated protein 29-like [KO:K18467]
104593537  vacuolar protein sorting-associated protein 26A-like [KO:K18466]
104609106  vacuolar protein sorting-associated protein 26A [KO:K18466]
104603625  vacuolar protein sorting-associated protein 35B-like [KO:K18468]
104604252  vacuolar protein sorting-associated protein 35B-like [KO:K18468]
104602359  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
104598827  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
104605118  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
104587212  AMSH-like ubiquitin thioesterase 2 [KO:K11866] [EC:3.4.19.12]
104592195  ras-related protein Rab7 [KO:K07897]
104595722  ras-related protein Rab7 [KO:K07897]
104595192  ras-related protein Rab7-like [KO:K07897]
104599986  ras-related protein Rab7-like [KO:K07897]
104587405  ras-related protein Rab7 [KO:K07897]
104601457  protein ELC-like [KO:K12183]
104609618  protein ELC-like [KO:K12183]
104609619  protein ELC-like [KO:K12183]
104613276  protein ELC-like [KO:K12183]
104609678  protein ELC-like [KO:K12183]
104605673  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
104612603  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
104604605  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
104586181  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
104605343  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
104587803  vacuolar protein sorting-associated protein 36 [KO:K12190]
104605258  vacuolar protein sorting-associated protein 25 [KO:K12189]
104606671  vacuolar protein sorting-associated protein 20 homolog 2 [KO:K12195]
104604451  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
104588221  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
104604533  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
104587368  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
104598347  vacuolar protein sorting-associated protein 2 homolog 2 [KO:K12191]
104598339  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
104600607  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
104609351  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
104600906  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
104602851  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
104585580  charged multivesicular body protein 7 [KO:K15053]
104588250  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
104607712  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
104594409  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
104606530  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5-like [KO:K12199]
104601266  ESCRT-related protein CHMP1B-like [KO:K12197]
104595817  ESCRT-related protein CHMP1-like [KO:K12197]
104597902  ESCRT-related protein CHMP1-like [KO:K12197]
104601495  ESCRT-related protein CHMP1A-like [KO:K12197]
104604428  ESCRT-related protein CHMP1B-like [KO:K12197]
104603046  ESCRT-related protein CHMP1B-like [KO:K12197]
104588198  ESCRT-related protein CHMP1B [KO:K12197]
104590140  charged multivesicular body protein 5-like [KO:K12198]
104601393  charged multivesicular body protein 5-like [KO:K12198]
104609203  charged multivesicular body protein 5-like [KO:K12198]
104594335  ALG-2 interacting protein X-like [KO:K12200]
104587741  ALG-2 interacting protein X [KO:K12200]
104611396  maspardin [KO:K19367]
104596239  maspardin-like [KO:K19367]
104589207  sorting nexin 1 [KO:K17917]
104607636  sorting nexin 1-like [KO:K17917]
104592231  ras-related protein RHN1-like [KO:K07889]
104606988  ras-related protein RHN1 [KO:K07889]
104594126  EH domain-containing protein 1-like [KO:K12483]
104606517  EH domain-containing protein 1 [KO:K12483]
104589255  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
104594607  ras-related protein RABE1c [KO:K07901]
104599292  ras-related protein RABE1c-like [KO:K07901]
104604564  ras-related protein RABE1c-like [KO:K07901]
104587337  ras-related protein RABE1c-like [KO:K07901]
104594049  ras-related protein RABA3 [KO:K07904]
104591257  ras-related protein RIC2 [KO:K07904]
104604522  ras-related protein Rab11A [KO:K07904]
104597489  ras-related protein RABA4d [KO:K07904]
104597069  ras-related protein Rab11C [KO:K07904]
104603163  ras-related protein RABA5a [KO:K07904]
104601140  ras-related protein Rab2BV [KO:K07904]
104603458  ras-related protein RGP1-like [KO:K07904]
104588971  ras-related protein RABA2a [KO:K07904]
104590466  ras-related protein RABA4d-like [KO:K07904]
104586291  ras-related protein RABA5c [KO:K07904]
104586543  ras-related protein RABA1d [KO:K07904]
104608657  ras-related protein Rab11A-like [KO:K07904]
104599511  ras-related protein RABA1f [KO:K07904]
104611064  ras-related protein RABA1f-like [KO:K07904]
104605670  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
104613368  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
104608809  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
104590137  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
104612599  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
104590053  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
104589176  probable ADP-ribosylation factor GTPase-activating protein AGD13 [KO:K12486]
104591852  ADP-ribosylation factor GTPase-activating protein AGD3 [KO:K12489]
104592757  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
104611806  ADP-ribosylation factor GTPase-activating protein AGD4-like [KO:K12489]
104594589  ADP-ribosylation factor GTPase-activating protein AGD7-like [KO:K12492]
104594590  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
104604598  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
104610346  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
104608777  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
104586714  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
104611051  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
104603821  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
104611857  brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
104612314  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
104585650  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
104605370  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
104607081  ADP-ribosylation factor [KO:K07937]
104607080  ADP-ribosylation factor 2-like [KO:K07937]
104611227  ADP-ribosylation factor [KO:K07937]
104607078  ADP-ribosylation factor [KO:K07937]
104607076  ADP-ribosylation factor [KO:K07937]
104588136  ADP-ribosylation factor 2-like [KO:K07937]
104591045  ADP-ribosylation factor [KO:K07937]
104587263  ADP-ribosylation factor-like [KO:K07937]
104612841  ADP-ribosylation factor 1-like 2 [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
nnu04070  Phosphatidylinositol signaling system
nnu04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
LinkDB

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