KEGG   PATHWAY: oco00061
Entry
oco00061                    Pathway                                
Name
Fatty acid biosynthesis - Afipia carboxidovorans OM4
Class
Metabolism; Lipid metabolism
Pathway map
oco00061  Fatty acid biosynthesis
oco00061

Module
oco_M00082  Fatty acid biosynthesis, initiation [PATH:oco00061]
oco_M00083  Fatty acid biosynthesis, elongation [PATH:oco00061]
oco_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:oco00061]
Other DBs
GO: 0006633
Organism
Afipia carboxidovorans OM4 [GN:oco]
Gene
OCA4_c04290  accA; acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
OCA4_c20430  biotin carboxyl carrier protein [KO:K02160]
OCA4_c20440  acetyl-CoA carboxylase, biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
OCA4_c00550  accD; acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
OCA4_c16740  fabD2; malonyl CoA-acyl carrier protein transacylase FabD [KO:K00645] [EC:2.3.1.39]
OCA4_c12130  fabD1; malonyl CoA-acyl carrier protein transacylase FabD [KO:K00645] [EC:2.3.1.39]
OCA4_c21410  fabH1; 3-oxoacyl-[acyl-carrier-protein] synthase FabH [KO:K00648] [EC:2.3.1.180]
OCA4_c31540  fabH2; 3-oxoacyl-[acyl-carrier-protein] synthase FabH [KO:K00648] [EC:2.3.1.180]
OCA4_c00360  fabB; 3-oxoacyl-[acyl-carrier-protein] synthase FabB [KO:K00647] [EC:2.3.1.41]
OCA4_c16770  fabF3; 3-oxoacyl-[acyl-carrier-protein] synthase FabF [KO:K09458] [EC:2.3.1.179]
OCA4_c15560  fabF1; 3-oxoacyl-[acyl-carrier-protein] synthase FabF [KO:K09458] [EC:2.3.1.179]
OCA4_c15570  putative 3-oxoacyl-(acyl-carrier-protein) synthase [KO:K09458] [EC:2.3.1.179]
OCA4_c15700  fabF2; 3-oxoacyl-[acyl-carrier-protein] synthase FabF [KO:K09458] [EC:2.3.1.179]
OCA4_c16750  fabG; 3-oxoacyl-(acyl-carrier-protein) reductase [KO:K00059] [EC:1.1.1.100]
OCA4_c10020  short-chain dehydrogenase/reductase family [KO:K00059] [EC:1.1.1.100]
OCA4_c00370  fabA; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase FabA [KO:K01716] [EC:4.2.1.59 5.3.3.14]
OCA4_c15580  fabA_fabZ; beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ [KO:K02372] [EC:4.2.1.59]
OCA4_c20570  fabZ; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
OCA4_c00350  fabI1; enoyl-[acyl-carrier-protein] reductase [NADH] [KO:K00208] [EC:1.3.1.9 1.3.1.10]
OCA4_c11800  fabI2; enoyl-[acyl-carrier-protein] reductase [NADH] 1 [KO:K00208] [EC:1.3.1.9 1.3.1.10]
OCA4_c30320  fabI3; enoyl-[acyl-carrier-protein] reductase [NADH] [KO:K00208] [EC:1.3.1.9 1.3.1.10]
OCA4_c12970  lcfB3; long-chain-fatty-acid--CoA ligase LcfB [KO:K01897] [EC:6.2.1.3]
OCA4_c07420  fadD; long-chain-fatty-acid--CoA ligase FadD [KO:K01897] [EC:6.2.1.3]
OCA4_c26670  lcfB4; long-chain-fatty-acid--CoA ligase LcfB [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
oco00020  Citrate cycle (TCA cycle)
oco00071  Fatty acid degradation
oco00074  Mycolic acid biosynthesis
oco00410  beta-Alanine metabolism
oco00561  Glycerolipid metabolism
oco00564  Glycerophospholipid metabolism
oco00620  Pyruvate metabolism
oco00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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