KEGG   PATHWAY: pcin04148
Entry
pcin04148                   Pathway                                
Name
Efferocytosis - Prosopis cineraria
Class
Cellular Processes; Transport and catabolism
Pathway map
pcin04148  Efferocytosis
pcin04148

Organism
Prosopis cineraria [GN:pcin]
Gene
129306090  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
129285811  sphingosine kinase 1-like isoform X1 [KO:K04718] [EC:2.7.1.91]
129314996  mitogen-activated protein kinase homolog NTF6-like [KO:K04371] [EC:2.7.11.24]
129308627  mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04368] [EC:2.7.12.2]
129306068  PWWP domain-containing protein 1-like [KO:K17398] [EC:2.1.1.37]
129295449  calcium-transporting ATPase 3, endoplasmic reticulum-type-like [KO:K05853] [EC:7.2.2.10]
129302981  calcium-transporting ATPase 3, endoplasmic reticulum-type [KO:K05853] [EC:7.2.2.10]
129302951  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
129295376  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
129321706  phospholipid-transporting ATPase 3 isoform X1 [KO:K14802] [EC:7.6.2.1]
129311124  phospholipid-transporting ATPase 3-like isoform X1 [KO:K14802] [EC:7.6.2.1]
129314277  LOW QUALITY PROTEIN: phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
129315863  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
129290606  LOW QUALITY PROTEIN: phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
129286001  putative ALA-interacting subunit 2 [KO:K26935]
129306226  ALA-interacting subunit 3-like [KO:K26935]
129313130  ALA-interacting subunit 3-like [KO:K26935]
129315873  ALA-interacting subunit 3-like [KO:K26935]
129317807  rac-like GTP-binding protein RAC1 [KO:K04392]
129306104  rac-like GTP-binding protein RAC13 [KO:K04392]
129293414  rac-like GTP-binding protein ARAC7 [KO:K04392]
129293722  rac-like GTP-binding protein RAC1 [KO:K04392]
129320169  rac-like GTP-binding protein ARAC8 isoform X1 [KO:K04392]
129321486  rac-like GTP-binding protein ARAC7 [KO:K04392]
129321879  rac-like GTP-binding protein RHO1 [KO:K04392]
129311195  rac-like GTP-binding protein RHO1 isoform X1 [KO:K04392]
129285899  rac-like GTP-binding protein RAC13 [KO:K04392]
129300706  rac-like GTP-binding protein RAC2 [KO:K04392]
129313584  rac-like GTP-binding protein RAC2 [KO:K04392]
129315532  rac-like GTP-binding protein RAC2 [KO:K04392]
129306952  calreticulin-3-like [KO:K08057]
129285982  calreticulin [KO:K08057]
129315411  calreticulin-3 isoform X1 [KO:K08057]
129315937  calreticulin-3-like [KO:K08057]
129292070  ras-related protein Rab5-like isoform X1 [KO:K07888]
129286678  ras-related protein RHN1-like isoform X1 [KO:K07888]
129317720  ras-related protein RHN1-like isoform X1 [KO:K07889]
129296049  ras-related protein RHN1 [KO:K07889]
129288113  ras-related protein RHN1-like isoform X1 [KO:K07889]
129302988  ras-related protein RHN1-like [KO:K07889]
129290568  vacuolar sorting protein 3 isoform X1 [KO:K20177]
129290548  uncharacterized protein LOC129290548 isoform X1 [KO:K20178]
129318248  vacuolar protein-sorting-associated protein 11 homolog isoform X1 [KO:K20179]
129303170  LOW QUALITY PROTEIN: protein VACUOLELESS1 [KO:K20180]
129314830  vacuolar sorting protein 18 isoform X1 [KO:K20181]
129314825  LOW QUALITY PROTEIN: vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
129322114  vacuolar sorting protein 39 [KO:K20183]
129313117  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
129316030  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
129293907  ras-related protein Rab7 isoform X1 [KO:K07897]
129308145  ras-related protein Rab7-like [KO:K07897]
129320852  ras-related protein Rab7-like [KO:K07897]
129286868  ras-related protein Rab7 [KO:K07897]
129287623  ras-related protein Rab7 [KO:K07897]
129314091  ras-related protein Rab7-like isoform X1 [KO:K07897]
129306559  uncharacterized protein LOC129306559 isoform X1 [KO:K23678]
129322800  probable vacuolar amino acid transporter YPQ1 isoform X1 [KO:K23678]
129287791  LOW QUALITY PROTEIN: arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
129307079  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
129284418  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
129317666  LOW QUALITY PROTEIN: triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
129317694  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
129317695  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
129292115  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
129308434  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
129295580  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
129303711  triacylglycerol lipase 2-like isoform X1 [KO:K01052] [EC:3.1.1.13]
129304359  triacylglycerol lipase 2 isoform X1 [KO:K01052] [EC:3.1.1.13]
129317426  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pcin00010  Glycolysis / Gluconeogenesis
pcin04145  Phagosome
KO pathway
ko04148   
LinkDB

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