KEGG   PATHWAY: plop04961
Entry
plop04961                   Pathway                                
Name
Endocrine and other factor-regulated calcium reabsorption - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems.
Class
Organismal Systems; Excretory system
Pathway map
plop04961  Endocrine and other factor-regulated calcium reabsorption
plop04961

Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125361176  parathyroid hormone-like [KO:K05261]
125362303  parathyroid hormone-like [KO:K05261]
125342288  Pth1r; LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor [KO:K04585]
125345113  LOW QUALITY PROTEIN: parathyroid hormone/parathyroid hormone-related peptide receptor-like [KO:K04585]
125353923  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125352423  neuroendocrine secretory protein 55-like [KO:K04632]
125365347  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125340976  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125365528  Vdr; vitamin D3 receptor [KO:K08539]
125357415  Esr1; estrogen receptor isoform X1 [KO:K08550]
125347258  Trpv5; transient receptor potential cation channel subfamily V member 5 isoform X1 [KO:K04974]
125348358  Kl; klotho [KO:K14756] [EC:3.2.1.31]
125360255  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
125349549  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
125348724  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
125362746  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
125338588  Ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
125366451  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
125352055  Ap2m1; AP-2 complex subunit mu [KO:K11826]
125359760  AP-2 complex subunit mu-like [KO:K11826]
125338766  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
125341484  Clta; clathrin light chain A [KO:K04644]
125342183  Cltb; clathrin light chain B [KO:K04645]
125366135  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
125340572  Rab11a; ras-related protein Rab-11A [KO:K07904]
125360475  Calb1; calbindin [KO:K14757]
125355464  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
125359069  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
125338561  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
125360159  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
125342654  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
125343057  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
125343594  Atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
125366115  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
125360108  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
125349609  Fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
125368402  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
125356518  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
125363265  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
125360457  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
125343642  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
125358779  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
125359435  Atp2b4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
125368107  kallikrein-1-like [KO:K01325] [EC:3.4.21.35]
125338534  Klk1; kallikrein-1 [KO:K01325] [EC:3.4.21.35]
125338541  kallikrein-1-like [KO:K01325] [EC:3.4.21.35]
125338543  kallikrein-2-like [KO:K01325] [EC:3.4.21.35]
125363290  Bdkrb2; B2 bradykinin receptor [KO:K03916]
125340416  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125353265  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125353267  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125340765  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125362680  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125340531  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125338673  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00951  Estradiol-17beta
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01673  Calcitriol
Reference
PMID:18989697
  Authors
Boros S, Bindels RJ, Hoenderop JG
  Title
Active Ca(2+) reabsorption in the connecting tubule.
  Journal
Pflugers Arch 458:99-109 (2009)
DOI:10.1007/s00424-008-0602-6
Reference
PMID:16518325
  Authors
Lambers TT, Bindels RJ, Hoenderop JG
  Title
Coordinated control of renal Ca2+ handling.
  Journal
Kidney Int 69:650-4 (2006)
DOI:10.1038/sj.ki.5000169
Reference
PMID:18596722
  Authors
de Groot T, Bindels RJ, Hoenderop JG
  Title
TRPV5: an ingeniously controlled calcium channel.
  Journal
Kidney Int 74:1241-6 (2008)
DOI:10.1038/ki.2008.320
Reference
PMID:20969972
  Authors
Markadieu N, Bindels RJ, Hoenderop JG
  Title
The renal connecting tubule: Resolved and unresolved issues in Ca(2+) transport.
  Journal
Int J Biochem Cell Biol 43:1-4 (2011)
DOI:10.1016/j.biocel.2010.10.006
Reference
PMID:15618484
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Calcium absorption across epithelia.
  Journal
Physiol Rev 85:373-422 (2005)
DOI:10.1152/physrev.00003.2004
Reference
PMID:15747113
  Authors
van Abel M, Hoenderop JG, Bindels RJ
  Title
The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 371:295-306 (2005)
DOI:10.1007/s00210-005-1021-2
Reference
PMID:16044309
  Authors
Nijenhuis T, Hoenderop JG, Bindels RJ
  Title
TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate.
  Journal
Pflugers Arch 451:181-92 (2005)
DOI:10.1007/s00424-005-1430-6
Reference
PMID:12684797
  Authors
Hoenderop JG, Nilius B, Bindels RJ
  Title
Epithelial calcium channels: from identification to function and regulation.
  Journal
Pflugers Arch 446:304-8 (2003)
DOI:10.1007/s00424-003-1045-8
Reference
PMID:17006539
  Authors
Gkika D, Topala CN, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop JG, Bindels RJ
  Title
Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
  Journal
EMBO J 25:4707-16 (2006)
DOI:10.1038/sj.emboj.7601357
Reference
PMID:17233615
  Authors
Schoeber JP, Hoenderop JG, Bindels RJ
  Title
Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.
  Journal
Biochem Soc Trans 35:115-9 (2007)
DOI:10.1042/BST0350115
Reference
PMID:18293139
  Authors
Renkema KY, Alexander RT, Bindels RJ, Hoenderop JG
  Title
Calcium and phosphate homeostasis: concerted interplay of new regulators.
  Journal
Ann Med 40:82-91 (2008)
DOI:10.1080/07853890701689645
Reference
PMID:19423690
  Authors
de Groot T, Lee K, Langeslag M, Xi Q, Jalink K, Bindels RJ, Hoenderop JG
  Title
Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation.
  Journal
J Am Soc Nephrol 20:1693-704 (2009)
DOI:10.1681/ASN.2008080873
Related
pathway
plop04144  Endocytosis
plop04530  Tight junction
KO pathway
ko04961   
LinkDB

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