KEGG   PATHWAY: reh00630
Entry
reh00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Cupriavidus necator H16
Class
Metabolism; Carbohydrate metabolism
Pathway map
reh00630  Glyoxylate and dicarboxylate metabolism
reh00630

Module
reh_M00012  Glyoxylate cycle [PATH:reh00630]
reh_M00621  Glycine cleavage system [PATH:reh00630]
Other DBs
GO: 0046487 0043648
Organism
Cupriavidus necator H16 [GN:reh]
Gene
H16_A2211  iclA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
H16_A2227  iclB; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
H16_A2525  acoE; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
H16_A1616  h16_A1616; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
H16_B0834  h16_B0834; Acetate-CoA ligase [KO:K01895] [EC:6.2.1.1]
H16_B1102  h16_B1102; Acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
H16_A1197  h16_A1197; Acyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
H16_A2217  aceB; malate synthase [KO:K01638] [EC:2.3.3.9]
H16_A2634  mdh1; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
H16_A1229  h16_A1229; citrate synthase [KO:K01647] [EC:2.3.3.1]
H16_A2627  cisY; citrate synthase [KO:K01647] [EC:2.3.3.1]
H16_B0414  h16_B0414; citrate synthase [KO:K01647] [EC:2.3.3.1]
H16_B2211  h16_B2211; citrate synthase [KO:K01647] [EC:2.3.3.1]
H16_B0357  h16_B0357; citrate synthase [KO:K01647] [EC:2.3.3.1]
H16_A2638  acnA; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
H16_B0568  acnB; aconitate hydratase 2 [KO:K01682] [EC:4.2.1.3 4.2.1.99]
H16_A1297  h16_A1297; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1438  phaA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1445  bktB; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1528  h16_A1528; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A2148  h16_A2148; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B1369  h16_B1369; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1887  h16_A1887; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0867  h16_A0867; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0868  h16_A0868; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0872  h16_A0872; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1713  h16_A1713; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1720  h16_A1720; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0170  h16_A0170; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0662  h16_B0662; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0668  h16_B0668; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0759  h16_B0759; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0406  h16_B0406; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0381  h16_B0381; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0380  h16_B0380; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B1771  h16_B1771; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1439  phaB1; Acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
H16_A2171  phaB3; Acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
H16_A2002  phaB2; Acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
H16_B0354  h16_B0354; dehydrogenase with MaoC-like domain [KO:K14449] [EC:4.2.1.148]
H16_B1757  h16_B1757; Acetyl/propionyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
H16_A1949  sbm2; Methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
H16_B1841  h16_B1841; Methylmalonyl-CoA mutase c-terminal domain/subunit (cobalamin-binding) [KO:K01849] [EC:5.4.99.2]
H16_B1842  h16_B1842; Methylmalonyl-CoA mutase alpha subunit [KO:K01848] [EC:5.4.99.2]
H16_A3094  glcD1; glycolate oxidase subunit GlcD [KO:K00104] [EC:1.1.99.14]
H16_A3096  glcE; 2-Hydroxy-acid oxidase, FAD-binding subunit [KO:K11472] [EC:1.1.99.14]
H16_A3097  glcF; 2-Hydroxy-acid oxidase, Fe-S subunit [KO:K11473] [EC:1.1.99.14]
H16_B1428  katE2; Catalase [KO:K03781] [EC:1.11.1.6]
H16_A3109  katE1; Catalase [KO:K03781] [EC:1.11.1.6]
H16_B0466  serA3; D-3-Phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
H16_A0185  h16_A0185; D-3-Phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
H16_A2586  h16_A2586; lactate dehydrogenase or related dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
H16_B0611  hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
H16_B1387  cbbZ2; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
H16_A3318  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
PHG419  cbbZp; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
H16_A2577  h16_A2577; predicted phosphatase [KO:K01091] [EC:3.1.3.18]
H16_B1395  cbbL2; ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit [KO:K01601] [EC:4.1.1.39]
PHG427  cbbLp; ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit [KO:K01601] [EC:4.1.1.39]
H16_B1394  cbbS2; ribulose bisphosphate carboxylase small chain [KO:K01602] [EC:4.1.1.39]
PHG426  cbbSp; ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit [KO:K01602] [EC:4.1.1.39]
H16_B1170  h16_B1170; aminotransferase class-V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
H16_B0618  glnA2; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
H16_B2191  glnA3; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
H16_A2834  glyA; Glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
H16_A3621  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
H16_A3619  gcvT1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
H16_A1377  pdhL; dihydrolipoamide dehydrogenase (E3) component ofpyruvate dehydrogenase [KO:K00382] [EC:1.8.1.4]
H16_A2323  odhL; dihydrolipoamide dehydrogenase (E3) [KO:K00382] [EC:1.8.1.4]
H16_B1098  h16_B1098; Pyridinenucleotide-disulphide (lipoamid) oxidoreductase [KO:K00382] [EC:1.8.1.4]
H16_A3620  gcvH; glycine cleavage system H [KO:K02437]
H16_A3598  h16_A3598; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
H16_A3599  hyi2; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
H16_A3600  h16_A3600; 2-Hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
H16_B0941  h16_B0941; NAD-dependent beta-hydroxyacid dehydrogenase [KO:K00042] [EC:1.1.1.60]
H16_A3004  h16_A3004; 3-Hydroxyisobutyrate dehydrogenase [KO:K00042] [EC:1.1.1.60]
H16_B0612  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
H16_A3601  ttuD1; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
H16_A2132  ttuD2; hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
H16_A0478  ldhA; dehydrogenase related to lactate dehydrogenases [KO:K11529] [EC:2.7.1.165]
H16_A2133  leuB2; 3-Isopropylmalate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
H16_A0477  leuB1; 3-Isopropylmalate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
H16_B1213  eda; 2-Keto-3-deoxy-6-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
H16_A0644  fdsD; NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
H16_A0642  fdsA; NAD-dependent formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
H16_B1700  fdwA; Tungsten-containing formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
H16_A2937  fdhA1; formate dehydrogenase alpha subunit (Fe4S4 domain) [KO:K00123] [EC:1.17.1.9]
H16_B1452  fdoG; formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
H16_B1701  fdwB; Tungsten-containing formate dehydrogenase beta subunit [KO:K22515] [EC:1.17.1.9]
H16_A2936  fdhB1; formate dehydrogenase iron-sulfur subunit [KO:K00124]
H16_B1453  fdoH; formate dehydrogenase beta subunit [KO:K00124]
H16_A0641  fdsB; NAD-dependent formate dehydrogenase beta subunit [KO:K00124]
H16_A0640  fdsG; NAD-dependent formate dehydrogenase gamma subunit [KO:K00127]
H16_A2934  fdhC; cytochrome b subunit of formate dehydrogenase [KO:K00127]
H16_B1454  fdoI; formate dehydrogenase gamma subunit [KO:K00127]
H16_B1997  h16_B1997; putative aylformamidase [KO:K01432] [EC:3.5.1.9]
H16_A3005  h16_A3005; putative aylformamidase [KO:K01432] [EC:3.5.1.9]
H16_A2814  h16_A2814; predicted metal-dependent hydrolase/Putative cyclase [KO:K07130] [EC:3.5.1.9]
H16_A2505  h16_A2505; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
H16_B1956  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
H16_B0476  fmdA2; Formamidase [KO:K01455] [EC:3.5.1.49]
H16_B0072  fmdA1; Formamidase [KO:K01455] [EC:3.5.1.49]
H16_B2459  aimE; aliphatic amidase [KO:K01455] [EC:3.5.1.49]
H16_A3013  hutG1; N-Formylglutamate amidohydrolase [KO:K01458] [EC:3.5.1.68]
H16_B1712  h16_B1712; Oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
H16_B1711  h16_B1711; Formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
H16_B1717  h16_B1717; Acyl-CoA transferase/carnitine dehydratase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
reh00010  Glycolysis / Gluconeogenesis
reh00020  Citrate cycle (TCA cycle)
reh00030  Pentose phosphate pathway
reh00053  Ascorbate and aldarate metabolism
reh00071  Fatty acid degradation
reh00230  Purine metabolism
reh00250  Alanine, aspartate and glutamate metabolism
reh00260  Glycine, serine and threonine metabolism
reh00620  Pyruvate metabolism
reh00710  Carbon fixation by Calvin cycle
reh00750  Vitamin B6 metabolism
reh00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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