KEGG   PATHWAY: rir00061
Entry
rir00061                    Pathway                                
Name
Fatty acid biosynthesis - Agrobacterium pusense IRBG74
Class
Metabolism; Lipid metabolism
Pathway map
rir00061  Fatty acid biosynthesis
rir00061

Module
rir_M00082  Fatty acid biosynthesis, initiation [PATH:rir00061]
rir_M00083  Fatty acid biosynthesis, elongation [PATH:rir00061]
rir_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:rir00061]
Other DBs
GO: 0006633
Organism
Agrobacterium pusense IRBG74 [GN:rir]
Gene
BN877_II0635  accA; acetylCoA carboxylase, alpha subunit [KO:K01962] [EC:6.4.1.2 2.1.3.15]
BN877_I1311  accB1; acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit [KO:K02160]
BN877_II1312  accB2; Biotin carboxyl carrier protein [KO:K02160]
BN877_I1310  accC1; acetyl CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
BN877_II1313  accC2; acetyl CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
BN877_I0021  accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain) [KO:K01963] [EC:6.4.1.2 2.1.3.15]
BN877_II0986  bccA; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [Includes: Biotin carboxylase; Biotin carboxyl carrier protein] [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
BN877_I1082  fabD; Malonyl CoA-acyl carrier protein transacylase (MCT) [KO:K00645] [EC:2.3.1.39]
BN877_I1173  fabH1; 3-oxoacyl-[acyl-carrier-protein] synthase III (Beta-ketoacyl-ACP synthase III)(KAS III) [KO:K00648] [EC:2.3.1.180]
BN877_II1130  fabH2; 3-oxoacyl-[acyl-carrier-protein] synthase III (Beta-ketoacyl-ACP synthase III)(KAS III) [KO:K00648] [EC:2.3.1.180]
BN877_I0148  fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I (Beta-ketoacyl-ACP synthase I) (KAS I) [KO:K00647] [EC:2.3.1.41]
BN877_I1086  fabF1; 3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
BN877_I1561  fabF2; 3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
BN877_I1562  fabF3; 3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
BN877_I1083  fabG1; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
BN877_I0976  conserved exported protein of unknown function [KO:K00059] [EC:1.1.1.100]
BN877_II0930  conserved protein of unknown function [KO:K00059] [EC:1.1.1.100]
BN877_II0823  fabG2; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
BN877_p0625  conserved protein of unknown function [KO:K00059] [EC:1.1.1.100]
BN877_p0081  putative 3-oxoacyl-acyl-carrier-protein reductase [KO:K00059] [EC:1.1.1.100]
BN877_p0084  putative oxidoreductase [KO:K00059] [EC:1.1.1.100]
BN877_I2620  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
BN877_I2628  putative oxidoreductase [KO:K00059] [EC:1.1.1.100]
BN877_I0149  fabA; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (Beta-hydroxydecanoyl thioester dehydrase) [KO:K01716] [EC:4.2.1.59 5.3.3.14]
BN877_I1369  fabZ1; (3R)-hydroxymyristol acyl carrier protein dehydratase [KO:K02372] [EC:4.2.1.59]
BN877_I1564  fabZ2; (3R)-hydroxymyristol acyl carrier protein dehydratase [KO:K02372] [EC:4.2.1.59]
BN877_I0147  fabI1; Enoyl-[acyl-carrier-protein] reductase [NADH] (NADH-dependent enoyl-ACP reductase) [KO:K00208] [EC:1.3.1.9 1.3.1.10]
BN877_I0733  fabI2; enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K00208] [EC:1.3.1.9 1.3.1.10]
BN877_I0410  fadD; Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
rir00020  Citrate cycle (TCA cycle)
rir00071  Fatty acid degradation
rir00410  beta-Alanine metabolism
rir00561  Glycerolipid metabolism
rir00564  Glycerophospholipid metabolism
rir00620  Pyruvate metabolism
rir00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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