KEGG   PATHWAY: rro03015
Entry
rro03015                    Pathway                                
Name
mRNA surveillance pathway - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
rro03015  mRNA surveillance pathway
rro03015

Other DBs
GO: 0071028
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104657781  NCBP1; nuclear cap-binding protein subunit 1 isoform X2 [KO:K12882]
104676372  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
115898630  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
104671541  UPF3B; regulator of nonsense transcripts 3B isoform X3 [KO:K14328]
104671360  UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A [KO:K14328]
104671043  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
104669313  MAGOH; protein mago nashi homolog [KO:K12877]
104659628  protein mago nashi homolog 2-like [KO:K12877]
104668628  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
115894574  protein mago nashi homolog 2 [KO:K12877]
104655111  CASC3; protein CASC3 [KO:K14323]
104675243  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104660778  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
104656928  PNN; pinin [KO:K13114]
104674147  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
104681573  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
104655016  ALYREF; THO complex subunit 4 [KO:K12881]
104677854  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
104677821  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
104660508  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
104664213  nuclear RNA export factor 2-like [KO:K14284]
104679330  NXF1; nuclear RNA export factor 1 [KO:K14284]
104678266  NXF3; nuclear RNA export factor 3 [KO:K14284]
104657745  nuclear RNA export factor 2 [KO:K14284]
115898698  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
104674382  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
104666927  NXT1; NTF2-related export protein 1 [KO:K14285]
104661907  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
104673703  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
104656104  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
104657908  RNGTT; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
104671855  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
104661574  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
104654365  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
104656047  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
104653614  embryonic polyadenylate-binding protein 2 [KO:K14396]
104664019  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
104679388  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
104658665  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
104673501  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
104668107  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
104654476  PAPOLA; poly(A) polymerase alpha isoform X2 [KO:K14376] [EC:2.7.7.19]
104677688  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
104661998  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
104671672  CPSF1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
104679040  CPSF2; LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
104675214  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
104660084  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
104672083  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
104666886  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
104662423  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
104663710  WDR82; WD repeat-containing protein 82 [KO:K14962]
104675136  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104664823  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104668466  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104653544  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
104656976  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
104675588  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
104676725  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
104658337  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
104673426  SYMPK; symplekin [KO:K06100]
104666250  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
104671453  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
104669812  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
104654873  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
104657746  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
104656172  polyadenylate-binding protein 1-like 2 [KO:K13126]
104659976  PABPC3; polyadenylate-binding protein 3 isoform X1 [KO:K13126]
104678860  PABPC1L; polyadenylate-binding protein 1-like isoform X3 [KO:K13126]
104670826  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
104671060  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
115898786  polyadenylate-binding protein 1-like 2 [KO:K13126]
104681729  ETF1; LOW QUALITY PROTEIN: eukaryotic peptide chain release factor subunit 1 [KO:K03265]
104667695  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X3 [KO:K03267]
104654572  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B isoform X1 [KO:K03267]
104680634  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
104664888  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
104667848  serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
104666802  SMG7; protein SMG7 isoform X1 [KO:K14409]
104664922  SMG5; protein SMG5 [KO:K11125]
104682020  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
104659809  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104668221  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104672685  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104677337  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
104659744  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
104678160  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104673955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104667559  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
104679853  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
104663356  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
104663566  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
115895932  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
104662840  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
104673923  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
104669493  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104667330  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104654440  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104668098  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
104680209  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
rro03013  Nucleocytoplasmic transport
rro03018  RNA degradation
rro03040  Spliceosome
KO pathway
ko03015   
LinkDB

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