KEGG   PATHWAY: rtu03070
Entry
rtu03070                    Pathway                                
Name
Bacterial secretion system - Rhizobium tumorigenes
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
rtu03070  Bacterial secretion system
rtu03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Rhizobium tumorigenes [GN:rtu]
Gene
PR017_01050  secD; protein translocase subunit SecD [KO:K12257]
PR017_08240  secDF; protein translocase subunit SecDF [KO:K12257]
PR017_05550  secE; preprotein translocase subunit SecE [KO:K03073]
PR017_06660  secG; preprotein translocase subunit SecG [KO:K03075]
PR017_05725  secY; preprotein translocase subunit SecY [KO:K03076]
PR017_08245  yajC; preprotein translocase subunit YajC [KO:K03210]
PR017_00380  yidC; membrane protein insertase YidC [KO:K03217]
PR017_13735  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
PR017_14625  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
PR017_15620  secB; protein-export chaperone SecB [KO:K03071]
PR017_14645  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
PR017_08290  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
PR017_08280  tatC; twin-arginine translocase subunit TatC [KO:K03118]
PR017_22380  type IV secretion system lytic transglycosylase VirB1 [KO:K03194]
PR017_23250  type IV secretion system lytic transglycosylase VirB1 [KO:K03194]
PR017_18000  TrbC/VirB2 family protein [KO:K03197]
PR017_22385  virB2; pilin major subunit VirB2 [KO:K03197]
PR017_23245  virB2; pilin major subunit VirB2 [KO:K03197]
PR017_23410  TrbC/VirB2 family protein [KO:K03197]
PR017_17995  VirB3 family type IV secretion system protein [KO:K03198]
PR017_22390  type IV secretion system protein VirB3 [KO:K03198]
PR017_23240  type IV secretion system protein VirB3 [KO:K03198]
PR017_23405  VirB3 family type IV secretion system protein [KO:K03198]
PR017_22400  virB5; pilin minor subunit VirB5 [KO:K03200]
PR017_23230  virB5; pilin minor subunit VirB5 [KO:K03200]
PR017_22410  type IV secretion system lipoprotein VirB7 [KO:K03202]
PR017_23220  type IV secretion system lipoprotein VirB7 [KO:K03202]
PR017_22420  virB9; P-type conjugative transfer protein VirB9 [KO:K03204]
PR017_23210  virB9; P-type conjugative transfer protein VirB9 [KO:K03204]
PR017_17970  type IV secretion system protein [KO:K03201]
PR017_22405  type IV secretion system protein [KO:K03201]
PR017_23225  type IV secretion system protein [KO:K03201]
PR017_23380  type IV secretion system protein [KO:K03201]
PR017_17965  type IV secretion system protein [KO:K03203]
PR017_22415  type IV secretion system protein VirB8 [KO:K03203]
PR017_23215  type IV secretion system protein VirB8 [KO:K03203]
PR017_23375  type IV secretion system protein [KO:K03203]
PR017_17955  virB10; type IV secretion system protein VirB10 [KO:K03195]
PR017_22425  virB10; type IV secretion system protein VirB10 [KO:K03195]
PR017_23205  virB10; type IV secretion system protein VirB10 [KO:K03195]
PR017_23365  virB10; type IV secretion system protein VirB10 [KO:K03195]
PR017_17990  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
PR017_22395  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
PR017_23235  virB4; type IV secretion/conjugal transfer ATPase VirB4 [KO:K03199] [EC:7.4.2.8]
PR017_23400  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
PR017_17950  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
PR017_22430  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
PR017_23200  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
PR017_23360  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
PR017_22000  traG; Ti-type conjugative transfer system protein TraG [KO:K03205] [EC:7.4.2.8]
PR017_22130  virD4; type IV secretion system ATPase VirD4 [KO:K03205] [EC:7.4.2.8]
PR017_22465  virD4; type IV secretion system ATPase VirD4 [KO:K03205] [EC:7.4.2.8]
PR017_23155  virD4; type IV secretion system ATPase VirD4 [KO:K03205] [EC:7.4.2.8]
PR017_23960  tssI; type VI secretion system tip protein TssI/VgrG [KO:K11904]
PR017_23940  type VI secretion system tube protein Hcp [KO:K11903]
PR017_23875  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
PR017_23880  tssL; type VI secretion system protein TssL, long form [KO:K11892]
PR017_23935  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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