KEGG   PATHWAY: rvl00999
Entry
rvl00999                    Pathway                                
Name
Biosynthesis of various plant secondary metabolites - Rhododendron vialii
  Including
Crocin biosynthesis, Ginsenoside biosynthesis, Saponin adjuvant biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
rvl00999  Biosynthesis of various plant secondary metabolites
rvl00999

Organism
Rhododendron vialii [GN:rvl]
Gene
131322416  beta-amyrin synthase-like [KO:K15813] [EC:5.4.99.39]
131325952  beta-amyrin synthase 1-like isoform X1 [KO:K15813] [EC:5.4.99.39]
131317787  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131332743  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131302277  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131302278  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131302279  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131302280  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131302318  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131335125  cytochrome P450 716A75-like [KO:K20667] [EC:1.14.14.126]
131335406  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131305857  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131305873  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131305889  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131306031  cytochrome P450 716A75-like [KO:K20667] [EC:1.14.14.126]
131336305  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131336444  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131336676  beta-amyrin 28-monooxygenase-like isoform X1 [KO:K20667] [EC:1.14.14.126]
131307443  beta-amyrin 6-beta-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131321743  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131322131  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131308588  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131308613  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131323755  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131323783  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131324880  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131313007  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131313008  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131328468  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131298564  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131298796  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131316863  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131316864  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
131320991  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
131308688  S-adenosylmethionine synthase 5-like [KO:K00789] [EC:2.5.1.6]
131325475  S-adenosylmethionine synthase 3-like isoform X1 [KO:K00789] [EC:2.5.1.6]
131327296  S-adenosylmethionine synthase 3-like isoform X1 [KO:K00789] [EC:2.5.1.6]
131314899  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
131307468  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
131301744  non-functional NADPH-dependent codeinone reductase 2-like isoform X1 [KO:K22374] [EC:1.1.1.285]
131301745  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
131301746  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
131336287  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
131310323  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
131325986  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
131334866  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
131334867  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
131315147  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like [KO:K13832] [EC:4.2.1.10 1.1.1.25]
131316836  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
131332297  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like [KO:K13832] [EC:4.2.1.10 1.1.1.25]
131307208  gallate 1-beta-glucosyltransferase 84A24-like [KO:K23279] [EC:2.4.1.136]
131334267  beta-glucosidase 12-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131334269  beta-glucosidase 12-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131334270  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
131334274  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
131335956  beta-glucosidase 11-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131321595  putative beta-glucosidase 41 isoform X1 [KO:K01188] [EC:3.2.1.21]
131311426  beta-glucosidase 40-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131311427  beta-glucosidase 40-like [KO:K01188] [EC:3.2.1.21]
131325819  beta-glucosidase 42 [KO:K01188] [EC:3.2.1.21]
131314498  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
131314648  beta-glucosidase 24-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131314649  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
131315001  beta-glucosidase 12-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131315073  beta-glucosidase 11-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131315294  beta-glucosidase 12-like isoform X1 [KO:K01188] [EC:3.2.1.21]
131315296  strictosidine-O-beta-D-glucosidase-like [KO:K01188] [EC:3.2.1.21]
131315297  raucaffricine-O-beta-D-glucosidase-like [KO:K01188] [EC:3.2.1.21]
131315299  strictosidine-O-beta-D-glucosidase-like [KO:K01188] [EC:3.2.1.21]
131315300  beta-glucosidase 24-like [KO:K01188] [EC:3.2.1.21]
131318508  uncharacterized protein LOC131318508 [KO:K05349] [EC:3.2.1.21]
131318509  uncharacterized protein LOC131318509 [KO:K05349] [EC:3.2.1.21]
131318510  uncharacterized protein LOC131318510 isoform X1 [KO:K05349] [EC:3.2.1.21]
131301952  uncharacterized protein LOC131301952 [KO:K05349] [EC:3.2.1.21]
131306884  uncharacterized protein LOC131306884 [KO:K05349] [EC:3.2.1.21]
131323684  uncharacterized protein LOC131323684 [KO:K05349] [EC:3.2.1.21]
131312462  uncharacterized protein LOC131312462 [KO:K05349] [EC:3.2.1.21]
131312476  uncharacterized protein LOC131312476 [KO:K05349] [EC:3.2.1.21]
131314347  uncharacterized protein LOC131314347 [KO:K05349] [EC:3.2.1.21]
131314348  uncharacterized protein LOC131314348 isoform X1 [KO:K05349] [EC:3.2.1.21]
131317031  uncharacterized protein LOC131317031 isoform X1 [KO:K05349] [EC:3.2.1.21]
131317048  uncharacterized protein LOC131317048 [KO:K05349] [EC:3.2.1.21]
131336319  beta-glucosidase 44-like isoform X1 [KO:K05350] [EC:3.2.1.21]
131311017  beta-glucosidase 46-like [KO:K05350] [EC:3.2.1.21]
131329245  beta-glucosidase 18-like [KO:K05350] [EC:3.2.1.21]
131329247  beta-glucosidase 18-like [KO:K05350] [EC:3.2.1.21]
131329248  probable inactive beta-glucosidase 14 isoform X1 [KO:K05350] [EC:3.2.1.21]
131315337  feruloyl CoA ortho-hydroxylase F6H1-3-like [KO:K06892] [EC:1.14.11.61]
131321855  scopoletin 8-hydroxylase [KO:K23145] [EC:1.14.11.60]
131319191  xanthotoxin 5-hydroxylase CYP82C4-like [KO:K23136] [EC:1.14.14.164]
131319630  xanthotoxin 5-hydroxylase CYP82C4-like [KO:K23136] [EC:1.14.14.164]
131307664  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308079  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308341  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308443  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308538  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308539  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308543  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131308547  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
131333837  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
Compound
C00019  S-Adenosyl-L-methionine
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00049  L-Aspartate
C00073  L-Methionine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00108  Anthranilate
C00179  Agmatine
C00223  p-Coumaroyl-CoA
C00251  Chorismate
C00254  Prephenate
C00323  Caffeoyl-CoA
C00353  Geranylgeranyl diphosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00448  trans,trans-Farnesyl diphosphate
C00463  Indole
C00493  Shikimate
C00590  Coniferyl alcohol
C00751  Squalene
C00758  Bergaptol
C00841  Xanthotoxol
C01054  (S)-2,3-Epoxysqualene
C01158  1-O-Galloyl-beta-D-glucose
C01198  3-(2-Hydroxyphenyl)propanoate
C01424  Gallate
C01527  Scopolin
C01557  Bergapten
C01752  Scopoletin
C01772  trans-2-Hydroxycinnamate
C01864  Xanthotoxin
C02162  Isopimpinellin
C02274  Dihydrocoumarin
C02637  3-Dehydroshikimate
C02951  5-Hydroxyxanthotoxin
C03506  Indoleglycerol phosphate
C04498  p-Coumaroylagmatine
C04576  Pentagalloylglucose
C04831  DIMBOA-glucoside
C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
C05324  Nicotianamine
C05366  (+)-Pinoresinol
C05838  cis-2-Hydroxycinnamate
C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
C05851  Coumarin
C06098  Zeaxanthin
C06972  Dronabinol
C07578  Cannabidiol
C08304  Gramine
C08307  Hordatine A
C08308  Hordatine B
C08588  Crocetin
C08589  Crocin
C08616  beta-Amyrin
C08942  Echinocystic acid
C08946  Ginsenoside Rg1
C08972  Quillaic acid
C09060  Angelicin
C09263  Esculetin
C09265  Fraxetin
C09276  Marmesin
C09305  Psoralen
C09311  Scoparone
C09315  Umbelliferone
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10646  Lariciresinol
C10682  Matairesinol
C10784  Cannabidiolic acid
C10874  Podophyllotoxin
C11130  3-Hydroxyindolin-2-one
C12312  Indolin-2-one
C15485  2'-Deoxymugineic acid
C15486  3''-Deamino-3''-oxonicotianamine
C15500  Mugineic acid
C15501  3-Epihydroxymugineic acid
C15502  3-Epihydroxy-2'-deoxymugineic acid
C15769  HBOA
C15770  DIBOA
C15772  DIBOA-glucoside
C17055  Picrocrocin
C17062  Safranal
C17148  Oleanolic acid
C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
C18062  TRIBOA-glucoside
C18079  Isoscopoletin
C18080  Osthenol
C18083  Demethylsuberosin
C18167  Secoisolariciresinol
C18325  Feruloylagmatine
C19707  (+)-Columbianetin
C19730  Crocetin dialdehyde
C19731  (3S)-3-Hydroxycyclocitral
C19829  Dammarenediol-II
C19867  beta-D-Glucosyl crocetin
C19868  Bis(beta-D-glucosyl) crocetin
C19869  beta-D-Gentiobiosyl crocetin
C20406  Cannabigerolate
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20713  Ginsenoside Rb1
C20715  Protopanaxadiol
C20716  Protopanaxatriol
C20725  Ginsenoside Rd
C20778  Ginsenoside Rg3
C20779  Ginsenoside F2
C20780  Ginsenoside F1
C20894  beta-Citraurin
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21459  6-Hydroxyferuloyl-CoA
C21601  3-(Aminomethyl)indole
C21602  (1H-Indol-3-yl)-N-methylmethanamine
C21903  Delta9-Tetrahydrocannabinolate
C22007  Sideretin
C22070  2,4-Dihydroxycinnamoyl-CoA
C22127  Ginsenoside C-K
C22128  (20S)-Ginsenoside Rh2
C22129  Ginsenoside Rh1
C22152  Bergamottin
C22153  Epoxybergamottin
C22156  6',7'-Dihydroxybergamottin
C22438  3,5-Dehydroshikimate
C22444  5,8-Dihydroxypsoralen
C22445  8-Hydroxybergapten
C22452  6,7,8-Trihydroxycoumarin
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22655  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22657  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22659  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22661  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22662  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22663  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22665  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
  Authors
Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  Title
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  Journal
FEBS Lett 586:1055-61 (2012)
DOI:10.1016/j.febslet.2012.03.003
Reference
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
Reference
PMID:9952442
  Authors
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  Title
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  Journal
Plant Physiol 119:471-80 (1999)
DOI:10.1104/pp.119.2.471
Reference
PMID:7622460
  Authors
Ma JF, Shinada T, Matsuda C, Nomoto K
  Title
Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  Journal
J Biol Chem 270:16549-54 (1995)
DOI:10.1074/jbc.270.28.16549
Reference
  Authors
Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  Title
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  Journal
Planta 253:3 (2020)
DOI:10.1007/s00425-020-03516-w
Reference
  Authors
Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  Title
The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  Journal
PLoS One 10:e0142757 (2015)
DOI:10.1371/journal.pone.0142757
Reference
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur J Biochem 271:932-40 (2004)
DOI:10.1111/j.1432-1033.2004.03995.x
Reference
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
Related
pathway
rvl00010  Glycolysis / Gluconeogenesis
rvl00020  Citrate cycle (TCA cycle)
rvl00270  Cysteine and methionine metabolism
rvl00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rvl00900  Terpenoid backbone biosynthesis
rvl00940  Phenylpropanoid biosynthesis
KO pathway
ko00999   
LinkDB

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