KEGG   PATHWAY: sen00630
Entry
sen00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Saccharopolyspora erythraea
Class
Metabolism; Carbohydrate metabolism
Pathway map
sen00630  Glyoxylate and dicarboxylate metabolism
sen00630

Module
sen_M00012  Glyoxylate cycle [PATH:sen00630]
sen_M00621  Glycine cleavage system [PATH:sen00630]
sen_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sen00630]
Other DBs
GO: 0046487 0043648
Organism
Saccharopolyspora erythraea [GN:sen]
Gene
SACE_1449  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
SACE_2375  acsA; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
SACE_2408  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
SACE_0337  acsA; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
SACE_4729  acsA; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
SACE_3902  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
SACE_6756  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
SACE_3674  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
SACE_0633  citA; citrate synthase [KO:K01647] [EC:2.3.3.1]
SACE_0649  gltA-2; citrate synthase [KO:K01647] [EC:2.3.3.1]
SACE_4339  acnA; aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
SACE_3754  acnA1; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
SACE_3811  acn; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
SACE_1192  mmgA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_2736  fadA6; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_7304  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_6236  fadA4; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_6363  fadA; acetyl CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
SACE_4011  catF; acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_0897  fadA3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SACE_6238  methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
SACE_6509  acetyl/propionyl-CoA carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SACE_3400  acetyl/propionyl-CoA carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SACE_3398  pccB; propionyl-CoA carboxylase beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
SACE_3399  Acetyl-CoA carboxylase, probable epsilon subunit [KO:K27095]
SACE_5639  mutB; methylmalonyl-CoA mutase (MCM) [KO:K01847] [EC:5.4.99.2]
SACE_5638  mutA; methylmalonyl-CoA mutase, beta subunit [KO:K01847] [EC:5.4.99.2]
SACE_6366  glcD; glycolate oxidase subunit [KO:K00104] [EC:1.1.99.14]
SACE_3889  FAD-binding oxidoreductase [KO:K00104] [EC:1.1.99.14]
SACE_3870  glcD2; putative glycolate oxidase [KO:K00104] [EC:1.1.99.14]
SACE_4261  glcD; (S)-2-hydroxy-acid oxidase, subunit D [KO:K00104] [EC:1.1.99.14]
SACE_6365  FAD linked oxidase-like [KO:K11472] [EC:1.1.99.14]
SACE_6364  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
SACE_4263  glcF; glycolate oxidase, iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
SACE_0302  katA; catalase [KO:K03781] [EC:1.11.1.6]
SACE_3861  katE; catalase HPII [KO:K03781] [EC:1.11.1.6]
SACE_2049  serA; glycerate dehydrogenase [KO:K00015] [EC:1.1.1.26]
SACE_0592  haloacid dehalogenase-like hydrolase [KO:K01091] [EC:3.1.3.18]
SACE_3639  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
SACE_1623  glnA-1; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SACE_1613  glnA2; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SACE_3095  glutamine synthetase (glutamate--ammonia ligase) [KO:K01915] [EC:6.3.1.2]
SACE_5355  glnA4; putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
SACE_5702  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SACE_4495  glyA2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SACE_3842  gcvP1; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
SACE_5701  gcvT; putative glycine cleavage system protein T (aminomethyltransferase) [KO:K00605] [EC:2.1.2.10]
SACE_1639  dldH2; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SACE_5677  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SACE_3846  gcvH; glycine cleavage system H protein [KO:K02437]
SACE_6378  gcvH; glycine cleavage system H protein [KO:K02437]
SACE_0494  gcvH; glycine cleavage system H protein [KO:K02437]
SACE_1935  gcl; putative glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
SACE_6729  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
SACE_6731  xylose isomerase domain protein TIM barrel [KO:K01816] [EC:5.3.1.22]
SACE_6730  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
SACE_1936  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
SACE_0098  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
SACE_6728  glxK; putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
SACE_3495  leuB1; 3-isopropylmalate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
SACE_4608  probable 3-isopropylmalate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
SACE_1739  kdgA; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SACE_5973  2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SACE_4936  probable 2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
SACE_6385  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
SACE_2432  formate dehydrogenase, alpha subunit [KO:K00123] [EC:1.17.1.9]
SACE_3562  formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
SACE_3561  molybdopterin oxidoreductase Fe4s4 region [KO:K00123] [EC:1.17.1.9]
SACE_3563  4Fe-4S ferredoxin, iron-sulfur binding protein [KO:K00124]
SACE_6982  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SACE_4502  purU-2; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
SACE_1932  formamidase [KO:K01455] [EC:3.5.1.49]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
sen00010  Glycolysis / Gluconeogenesis
sen00020  Citrate cycle (TCA cycle)
sen00030  Pentose phosphate pathway
sen00053  Ascorbate and aldarate metabolism
sen00071  Fatty acid degradation
sen00230  Purine metabolism
sen00250  Alanine, aspartate and glutamate metabolism
sen00260  Glycine, serine and threonine metabolism
sen00620  Pyruvate metabolism
sen00710  Carbon fixation by Calvin cycle
sen00750  Vitamin B6 metabolism
sen00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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