KEGG   PATHWAY: sfic00630
Entry
sfic00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Streptomyces ficellus
Class
Metabolism; Carbohydrate metabolism
Pathway map
sfic00630  Glyoxylate and dicarboxylate metabolism
sfic00630

Module
sfic_M00012  Glyoxylate cycle [PATH:sfic00630]
sfic_M00621  Glycine cleavage system [PATH:sfic00630]
sfic_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sfic00630]
Other DBs
GO: 0046487 0043648
Organism
Streptomyces ficellus [GN:sfic]
Gene
EIZ62_01385  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
EIZ62_14730  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
EIZ62_05960  AMP-dependent synthetase [KO:K01895] [EC:6.2.1.1]
EIZ62_01390  malate synthase A [KO:K01638] [EC:2.3.3.9]
EIZ62_05810  malate synthase A [KO:K01638] [EC:2.3.3.9]
EIZ62_12435  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
EIZ62_18520  citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
EIZ62_21715  citrate synthase [KO:K01647] [EC:2.3.3.1]
EIZ62_06760  acnA; aconitate hydratase AcnA [KO:K01681] [EC:4.2.1.3]
EIZ62_23420  steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
EIZ62_19915  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
EIZ62_25040  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
EIZ62_31155  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
EIZ62_04580  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
EIZ62_09540  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
EIZ62_09545  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
EIZ62_05460  protein meaA [KO:K14447] [EC:5.4.99.63]
EIZ62_19165  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
EIZ62_11945  biotin/lipoyl-binding protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
EIZ62_11905  acyl-CoA carboxylase subunit beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
EIZ62_11910  acyl-CoA carboxylase subunit epsilon [KO:K27095]
EIZ62_02485  methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
EIZ62_02490  methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
EIZ62_12170  methylmalonyl-CoA mutase [KO:K01848] [EC:5.4.99.2]
EIZ62_20800  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
EIZ62_30590  catalase [KO:K03781] [EC:1.11.1.6]
EIZ62_10765  catalase [KO:K03781] [EC:1.11.1.6]
EIZ62_00770  catalase [KO:K03781] [EC:1.11.1.6]
EIZ62_05890  catalase [KO:K03781] [EC:1.11.1.6]
EIZ62_21195  phosphonatase-like hydrolase [KO:K01091] [EC:3.1.3.18]
EIZ62_18205  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
EIZ62_24040  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
EIZ62_24095  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
EIZ62_23865  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
EIZ62_27175  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
EIZ62_12345  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EIZ62_09155  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EIZ62_09805  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EIZ62_28365  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EIZ62_09145  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EIZ62_24185  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EIZ62_16600  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EIZ62_09150  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EIZ62_05945  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
EIZ62_05880  hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
EIZ62_05885  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
EIZ62_05500  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EIZ62_23575  eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
EIZ62_01180  bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
EIZ62_10405  multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
EIZ62_18625  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
sfic00010  Glycolysis / Gluconeogenesis
sfic00020  Citrate cycle (TCA cycle)
sfic00030  Pentose phosphate pathway
sfic00053  Ascorbate and aldarate metabolism
sfic00071  Fatty acid degradation
sfic00230  Purine metabolism
sfic00250  Alanine, aspartate and glutamate metabolism
sfic00260  Glycine, serine and threonine metabolism
sfic00620  Pyruvate metabolism
sfic00710  Carbon fixation by Calvin cycle
sfic00750  Vitamin B6 metabolism
sfic00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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