KEGG   PATHWAY: shns00030
Entry
shns00030                   Pathway                                
Name
Pentose phosphate pathway - Shewanella alkalitolerans
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
shns00030  Pentose phosphate pathway
shns00030

Module
shns_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:shns00030]
shns_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:shns00030]
shns_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:shns00030]
shns_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:shns00030]
shns_M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:shns00030]
Other DBs
GO: 0006098
Organism
Shewanella alkalitolerans [GN:shns]
Gene
K0J45_05435  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
K0J45_10450  zwf; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
K0J45_10445  pgl; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
K0J45_13180  gndA; NADP-dependent phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
K0J45_01155  rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
K0J45_03840  tkt; transketolase [KO:K00615] [EC:2.2.1.1]
K0J45_05440  tal; transaldolase [KO:K00616] [EC:2.2.1.2]
K0J45_04205  rpiA; ribose-5-phosphate isomerase RpiA [KO:K01807] [EC:5.3.1.6]
K0J45_05450  phosphoketolase family protein [KO:K01621] [EC:4.1.2.9 4.1.2.22]
K0J45_14450  deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
K0J45_03550  rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
K0J45_14440  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
K0J45_09820  pgm; phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) [KO:K01835] [EC:5.4.2.2]
K0J45_14955  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
K0J45_10440  edd; phosphogluconate dehydratase [KO:K01690] [EC:4.2.1.12]
K0J45_10435  bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
K0J45_15345  gluconate 2-dehydrogenase subunit 3 family protein [KO:K06152] [EC:1.1.99.3]
K0J45_03855  fba; fructose-bisphosphate aldolase class II [KO:K01624] [EC:4.1.2.13]
K0J45_03960  class 1 fructose-bisphosphatase [KO:K03841] [EC:3.1.3.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
shns00010  Glycolysis / Gluconeogenesis
shns00040  Pentose and glucuronate interconversions
shns00052  Galactose metabolism
shns00230  Purine metabolism
shns00240  Pyrimidine metabolism
shns00340  Histidine metabolism
shns00630  Glyoxylate and dicarboxylate metabolism
shns00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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