KEGG   PATHWAY: smul00730
Entry
smul00730                   Pathway                                
Name
Thiamine metabolism - Sulfurospirillum multivorans
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
smul00730  Thiamine metabolism
smul00730

Module
smul_M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:smul00730]
Other DBs
GO: 0006772
Organism
Sulfurospirillum multivorans [GN:smul]
Gene
SMUL_0724  thiC; thiamin biosynthesis protein ThiC [KO:K03147] [EC:4.1.99.17]
SMUL_1344  thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [KO:K00941] [EC:2.7.1.49 2.7.4.7]
SMUL_2995  iscS; cysteine desulfurase [KO:K04487] [EC:2.8.1.7]
SMUL_0299  dxs; 1-deoxy-D-xylulose 5-phosphate synthase [KO:K01662] [EC:2.2.1.7]
SMUL_3005  thiG; thiazole synthase ThiG [KO:K03149] [EC:2.8.1.10]
SMUL_1346  thiM; hydroxyethylthiazole kinase [KO:K00878] [EC:2.7.1.50]
SMUL_1027  thiE; thiamine-phosphate synthase [KO:K00788] [EC:2.5.1.3]
SMUL_1397  putative thiamine monophosphate synthase [KO:K00788] [EC:2.5.1.3]
SMUL_1337  thiL; thiamine-monophosphate kinase [KO:K00946] [EC:2.7.4.16]
SMUL_0857  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
smul00010  Glycolysis / Gluconeogenesis
smul00230  Purine metabolism
smul00260  Glycine, serine and threonine metabolism
smul00270  Cysteine and methionine metabolism
smul00400  Phenylalanine, tyrosine and tryptophan biosynthesis
smul00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

DBGET integrated database retrieval system