KEGG   PATHWAY: tad04150
Entry
tad04150                    Pathway                                
Name
mTOR signaling pathway - Trichoplax adhaerens (placozoan)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
tad04150  mTOR signaling pathway
tad04150

Organism
Trichoplax adhaerens (placozoan) [GN:tad]
Gene
TRIADDRAFT_29287  hypothetical protein [KO:K14995]
TRIADDRAFT_29059  hypothetical protein [KO:K14995]
TRIADDRAFT_29379  hypothetical protein [KO:K14995]
TRIADDRAFT_29062  hypothetical protein [KO:K14995]
TRIADDRAFT_50246  hypothetical protein [KO:K02145] [EC:7.1.2.2]
TRIADDRAFT_32492  hypothetical protein [KO:K02147]
TRIADDRAFT_19844  hypothetical protein [KO:K02148]
TRIADDRAFT_63587  expressed hypothetical protein [KO:K02149]
TRIADDRAFT_63784  expressed hypothetical protein [KO:K02150]
TRIADDRAFT_37267  expressed hypothetical protein [KO:K02151]
TRIADDRAFT_63629  expressed hypothetical protein [KO:K02152]
TRIADDRAFT_36227  hypothetical protein [KO:K02144]
TRIADDRAFT_56564  hypothetical protein [KO:K20397]
TRIADDRAFT_52985  hypothetical protein [KO:K20398]
TRIADDRAFT_59357  hypothetical protein [KO:K04370]
TRIADDRAFT_53485  hypothetical protein [KO:K09594]
TRIADDRAFT_55844  hypothetical protein [KO:K20401]
TRIADDRAFT_49549  hypothetical protein [KO:K16185]
TRIADDRAFT_61123  hypothetical protein [KO:K16186]
TRIADDRAFT_23176  hypothetical protein [KO:K20407]
TRIADDRAFT_55614  hypothetical protein [KO:K14299]
TRIADDRAFT_54980  hypothetical protein [KO:K20408]
TRIADDRAFT_55691  hypothetical protein [KO:K20409]
TRIADDRAFT_24138  hypothetical protein [KO:K14004]
TRIADDRAFT_21042  hypothetical protein [KO:K07204]
TRIADDRAFT_63504  hypothetical protein [KO:K16184]
TRIADDRAFT_57462  hypothetical protein [KO:K07203] [EC:2.7.11.1]
TRIADDRAFT_58260  hypothetical protein [KO:K20402]
TRIADDRAFT_21796  hypothetical protein [KO:K08266]
TRIADDRAFT_53547  hypothetical protein [KO:K11137]
TRIADDRAFT_51768  hypothetical protein [KO:K20403]
TRIADDRAFT_64321  hypothetical protein [KO:K15728] [EC:3.1.3.4]
TRIADDRAFT_29099  hypothetical protein [KO:K08269] [EC:2.7.11.1]
TRIADDRAFT_28470  hypothetical protein [KO:K03259]
TRIADDRAFT_52187  hypothetical protein [KO:K03259]
TRIADDRAFT_28822  hypothetical protein [KO:K04688] [EC:2.7.11.1]
TRIADDRAFT_53556  hypothetical protein [KO:K03258]
TRIADDRAFT_63768  expressed hypothetical protein [KO:K02991]
TRIADDRAFT_53554  hypothetical protein [KO:K08271]
TRIADDRAFT_29179  hypothetical protein [KO:K07298] [EC:2.7.11.1]
TRIADDRAFT_63161  hypothetical protein [KO:K08272]
TRIADDRAFT_37919  hypothetical protein [KO:K07198] [EC:2.7.11.31]
TRIADDRAFT_53459  hypothetical protein [KO:K07206]
TRIADDRAFT_60832  hypothetical protein [KO:K07207]
TRIADDRAFT_53571  hypothetical protein [KO:K07208]
TRIADDRAFT_52489  hypothetical protein [KO:K00182]
TRIADDRAFT_30370  hypothetical protein [KO:K00572]
TRIADDRAFT_31674  hypothetical protein [KO:K02842]
TRIADDRAFT_19424  hypothetical protein [KO:K03068]
TRIADDRAFT_56049  hypothetical protein [KO:K03083] [EC:2.7.11.26]
TRIADDRAFT_22855  hypothetical protein [KO:K04527] [EC:2.7.10.1]
TRIADDRAFT_62057  hypothetical protein [KO:K03099]
TRIADDRAFT_29518  hypothetical protein [KO:K02833]
TRIADDRAFT_50661  hypothetical protein [KO:K04371] [EC:2.7.11.24]
TRIADDRAFT_60987  hypothetical protein [KO:K04373] [EC:2.7.11.1]
TRIADDRAFT_26293  hypothetical protein [KO:K00922] [EC:2.7.1.153]
TRIADDRAFT_28654  hypothetical protein [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
TRIADDRAFT_31577  hypothetical protein [KO:K06276] [EC:2.7.11.1]
TRIADDRAFT_51134  hypothetical protein [KO:K04456] [EC:2.7.11.1]
TRIADDRAFT_62259  hypothetical protein [KO:K04467] [EC:2.7.11.10]
TRIADDRAFT_52453  hypothetical protein [KO:K20410]
TRIADDRAFT_58016  hypothetical protein [KO:K08267]
TRIADDRAFT_54779  hypothetical protein [KO:K20411]
TRIADDRAFT_20369  hypothetical protein [KO:K04513]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
tad00561  Glycerolipid metabolism
tad04140  Autophagy - animal
KO pathway
ko04150   
LinkDB

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