KEGG   PATHWAY: tdc00790
Entry
tdc00790                    Pathway                                
Name
Folate biosynthesis - Triticum dicoccoides (wild emmer wheat)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
tdc00790  Folate biosynthesis
tdc00790

Module
tdc_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:tdc00790]
tdc_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:tdc00790]
Other DBs
GO: 0046656
Organism
Triticum dicoccoides (wild emmer wheat) [GN:tdc]
Gene
119365927  GTP cyclohydrolase 1-like [KO:K01495] [EC:3.5.4.16]
119356707  GTP cyclohydrolase 1-like [KO:K01495] [EC:3.5.4.16]
119316902  alkaline phosphatase D-like isoform X1 [KO:K01113] [EC:3.1.3.1]
119323741  alkaline phosphatase D-like isoform X1 [KO:K01113] [EC:3.1.3.1]
119331376  dihydroneopterin aldolase 2-like [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
119318347  dihydroneopterin aldolase 2-like [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
119338003  dihydroneopterin aldolase 1-like [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
119360796  dihydroneopterin aldolase 2-like [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
119353780  folate synthesis bifunctional protein, mitochondrial-like isoform X1 [KO:K13941] [EC:2.7.6.3 2.5.1.15]
119362965  folate synthesis bifunctional protein, mitochondrial-like isoform X1 [KO:K13941] [EC:2.7.6.3 2.5.1.15]
119366109  putative bifunctional dihydrofolate reductase-thymidylate synthase isoform X1 [KO:K13998] [EC:1.5.1.3 2.1.1.45]
119356870  putative bifunctional dihydrofolate reductase-thymidylate synthase isoform X1 [KO:K13998] [EC:1.5.1.3 2.1.1.45]
119292355  folylpolyglutamate synthase-like [KO:K01930] [EC:6.3.2.17]
119335487  folylpolyglutamate synthase-like isoform X1 [KO:K01930] [EC:6.3.2.17]
119270964  folylpolyglutamate synthase-like isoform X1 [KO:K01930] [EC:6.3.2.17]
119304389  folylpolyglutamate synthase-like [KO:K01930] [EC:6.3.2.17]
119298867  dihydrofolate synthetase-like isoform X1 [KO:K20457] [EC:6.3.2.12]
119307138  dihydrofolate synthetase-like [KO:K20457] [EC:6.3.2.12]
119349013  gamma-glutamyl hydrolase 1-like [KO:K01307] [EC:3.4.19.9]
119287156  gamma-glutamyl hydrolase 1-like [KO:K01307] [EC:3.4.19.9]
119347507  probable monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic isoform X1 [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119328589  probable bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119316949  probable bifunctional riboflavin biosynthesis protein RIBA 2, chloroplastic isoform X1 [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119282479  probable monofunctional riboflavin biosynthesis protein RIBA 3, chloroplastic isoform X1 [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119336392  probable bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119322167  probable bifunctional riboflavin biosynthesis protein RIBA 2, chloroplastic [KO:K14652] [EC:4.1.99.12 3.5.4.25]
119328347  probable aminodeoxychorismate synthase, chloroplastic isoform X1 [KO:K13950] [EC:2.6.1.85]
119336017  probable aminodeoxychorismate synthase, chloroplastic isoform X1 [KO:K13950] [EC:2.6.1.85]
119275599  D-amino-acid transaminase, chloroplastic-like [KO:K18482] [EC:4.1.3.38]
119316537  D-amino-acid transaminase, chloroplastic-like [KO:K18482] [EC:4.1.3.38]
119267733  D-amino-acid transaminase, chloroplastic-like [KO:K18482] [EC:4.1.3.38]
119324285  D-amino-acid transaminase, chloroplastic-like [KO:K18482] [EC:4.1.3.38]
119326241  (+)-neomenthol dehydrogenase-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119364776  (+)-neomenthol dehydrogenase-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119278271  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119317062  (+)-neomenthol dehydrogenase-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119355611  (+)-neomenthol dehydrogenase-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119270208  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
119279572  uncharacterized protein LOC119279572 [KO:K01724] [EC:4.2.1.96]
119317962  pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial-like isoform X1 [KO:K01724] [EC:4.2.1.96]
119322520  pterin-4-alpha-carbinolamine dehydratase 2, mitochondrial-like isoform X1 [KO:K01724] [EC:4.2.1.96]
119299325  GTP 3',8-cyclase, mitochondrial-like [KO:K03639] [EC:4.1.99.22]
119307521  GTP 3',8-cyclase, mitochondrial-like [KO:K03639] [EC:4.1.99.22]
119364503  cyclic pyranopterin monophosphate synthase, mitochondrial-like [KO:K03637] [EC:4.6.1.17]
119355384  cyclic pyranopterin monophosphate synthase, mitochondrial-like [KO:K03637] [EC:4.6.1.17]
119299507  molybdopterin synthase catalytic subunit-like [KO:K03635] [EC:2.8.1.12]
119309093  molybdopterin synthase catalytic subunit-like [KO:K03635] [EC:2.8.1.12]
119365957  molybdopterin biosynthesis protein CNX1-like [KO:K15376] [EC:2.10.1.1 2.7.7.75]
119356729  molybdopterin biosynthesis protein CNX1-like [KO:K15376] [EC:2.10.1.1 2.7.7.75]
119329666  molybdenum cofactor sulfurase-like [KO:K15631] [EC:2.8.1.9]
119336827  molybdenum cofactor sulfurase-like [KO:K15631] [EC:2.8.1.9]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
tdc00230  Purine metabolism
tdc00400  Phenylalanine, tyrosine and tryptophan biosynthesis
tdc00670  One carbon pool by folate
KO pathway
ko00790   
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