KEGG   PATHWAY: theh00290
Entry
theh00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Thermomonas sp. HDW16
Class
Metabolism; Amino acid metabolism
Pathway map
theh00290  Valine, leucine and isoleucine biosynthesis
theh00290

Module
theh_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:theh00290]
theh_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:theh00290]
theh_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:theh00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Thermomonas sp. HDW16 [GN:theh]
Gene
G7079_01445  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
G7079_03345  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
G7079_03335  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
G7079_03330  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
G7079_03325  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
G7079_03360  acetolactate synthase 2 catalytic subunit [KO:K01652] [EC:2.2.1.6]
G7079_03355  acetolactate synthase [KO:K11258] [EC:2.2.1.6]
G7079_03365  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
G7079_03370  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
G7079_03350  branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
G7079_03930  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
G7079_08955  Glu/Leu/Phe/Val dehydrogenase [KO:K00263] [EC:1.4.1.9]
G7079_02560  pyridoxal phosphate-dependent aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
G7079_03340  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
theh00260  Glycine, serine and threonine metabolism
theh00280  Valine, leucine and isoleucine degradation
theh00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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