Entry
Name
Folate biosynthesis - Tuwongella immobilis
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Tuwongella immobilis [GN:
tim ]
Gene
GMBLW1_08130 gtp cyclohydrolase i : GTP cyclohydrolase 1 OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=folE PE=3 SV=1: GTP_cyclohydroI [KO:K01495 ] [EC:3.5.4.16 ]
GMBLW1_41620 Phosphodiesterase/alkaline phosphatase D OS=uncultured planctomycete GN=HGMM_F11F07C03 PE=4 SV=1: PhoD [KO:K01113 ] [EC:3.1.3.1 ]
GMBLW1_44740 Alkaline phosphatase OS=Chroococcidiopsis thermalis PCC 7203 GN=Chro_0947 PE=4 SV=1: PhoD [KO:K01113 ] [EC:3.1.3.1 ]
GMBLW1_30220 alkaline phosphatase : Alkaline phosphatase D (Precursor) OS=Planctomyces maris DSM 8797 GN=PM8797T_14564 PE=4 SV=1: PhoD [KO:K01113 ] [EC:3.1.3.1 ]
GMBLW1_00460 dihydropteroate synthase : Dihydropteroate synthase OS=uncultured planctomycete GN=HGMM_F11F07C23 PE=3 SV=1: Pterin_bind [KO:K00796 ] [EC:2.5.1.15 ]
GMBLW1_44830 bifunctional folylpolyglutamate synthase dihydrofolate synthase : Folylpolyglutamate synthase/dihydrofolate synthase OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=Sinac_5224 PE=4 SV=1: Mur_ligase_M [KO:K11754 ] [EC:6.3.2.12 6.3.2.17 ]
GMBLW1_51520 -dihydroxy-2-butanone 4-phosphate synthase : Riboflavin biosynthesis protein RibBA OS=Thermodesulfobacterium commune DSM 2178 GN=ribBA PE=3 SV=1: DHBP_synthase: GTP_cyclohydro2 [KO:K14652 ] [EC:4.1.99.12 3.5.4.25 ]
GMBLW1_08560 para-aminobenzoate synthase : Chorismate binding-like protein OS=Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) GN=Psta_2633 PE=4 SV=1: Anth_synt_I_N: Chorismate_bind [KO:K01665 ] [EC:2.6.1.85 ]
GMBLW1_07600 6-pyruvoyl-tetrahydropterin synthase OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=Sinac_5864 PE=4 SV=1: PTPS [KO:K01737 ] [EC:4.2.3.12 4.1.2.50 ]
GMBLW1_24460 6-pyruvoyl-tetrahydropterin synthase OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=Sinac_1233 PE=4 SV=1: PTPS [KO:K01737 ] [EC:4.2.3.12 4.1.2.50 ]
GMBLW1_49280 pterin-4-alpha-carbinolamine dehydratase : 4a-hydroxytetrahydrobiopterin dehydratase OS=Galdieria sulphuraria GN=Gasu_27700 PE=4 SV=1: Pterin_4a [KO:K01724 ] [EC:4.2.1.96 ]
GMBLW1_13940 short-chain dehydrogenase reductase sdr : Short-chain dehydrogenase/reductase SDR OS=Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) GN=Psta_1052 PE=4 SV=1: adh_short [KO:K03793 ] [EC:1.5.1.33 ]
GMBLW1_45970 7-carboxy-7-deazaguanine synthase : 7-carboxy-7-deazaguanine synthase OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=queE PE=3 SV=1: Fer4_14: Radical_SAM [KO:K10026 ] [EC:4.3.99.3 ]
GMBLW1_07610 family transcriptional regulator : 7-cyano-7-deazaguanine synthase OS=Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) GN=Psta_4201 PE=4 SV=1: QueC [KO:K06920 ] [EC:6.3.4.20 ]
GMBLW1_29500 7-cyano-7-deazaguanine synthase : 7-cyano-7-deazaguanine synthase OS=Myxococcus fulvus (strain ATCC BAA-855 / HW-1) GN=queC PE=3 SV=1: QueC [KO:K06920 ] [EC:6.3.4.20 ]
GMBLW1_29510 7-cyano-7-deazaguanine reductase : NADPH-dependent 7-cyano-7-deazaguanine reductase OS=Rhodopirellula sallentina SM41 GN=queF PE=3 SV=1: QueF [KO:K09457 ] [EC:1.7.1.13 ]
GMBLW1_08230 ghmp kinase : Beta-ribofuranosylaminobenzene 5'-phosphate synthase OS=Gemmata sp. Wa1-1 GN=mptG PE=4 SV=1: GHMP_kinases_N: GHMP_kinases_C [KO:K06984 ] [EC:2.4.2.54 ]
GMBLW1_05850 alpha-l-glutamate ligase : Alpha-L-glutamate ligase, RimK family OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=Sinac_1235 PE=4 SV=1: RimK [KO:K15740 ] [EC:6.3.2.33 ]
GMBLW1_08090 molybdenum cofactor biosynthesis protein : Cyclic pyranopterin monophosphate synthase OS=Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B) GN=moaA PE=3 SV=1: Radical_SAM: Fer4_12: Mob_synth_C [KO:K03639 ] [EC:4.1.99.22 ]
GMBLW1_06930 molybdenum cofactor biosynthesis protein : Cyclic pyranopterin monophosphate synthase accessory protein OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=moaC PE=3 SV=1: MoaC [KO:K03637 ] [EC:4.6.1.17 ]
GMBLW1_08100 molybdenum cofactor biosynthesis protein : Molybdopterin converting factor (Subunit 2) OS=Planctomyces maris DSM 8797 GN=PM8797T_13453 PE=4 SV=1: MoaE [KO:K03635 ] [EC:2.8.1.12 ]
GMBLW1_19340 molybdopterin adenylyltransferase : Molybdopterin adenylyltransferase OS=Hydrogenovibrio marinus GN=EI16_04715 PE=4 SV=1: MoCF_biosynth [KO:K03831 ] [EC:2.7.7.75 ]
GMBLW1_28630 molybdenum cofactor synthesis domain protein : Molybdenum cofactor synthesis domain protein OS=Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10) GN=Sinac_6558 PE=4 SV=1: MoeA_N: MoCF_biosynth: MoeA_C [KO:K03750 ] [EC:2.10.1.1 ]
GMBLW1_00280 molybdopterin-guanine dinucleotide biosynthesis protein a : Molybdenum cofactor guanylyltransferase OS=Candidatus Entotheonella sp. TSY2 GN=mobA PE=3 SV=1: NTP_transf_3 [KO:K03752 ] [EC:2.7.7.77 ]
Compound
C00119 5-Phospho-alpha-D-ribose 1-diphosphate
C01217 5,6,7,8-Tetrahydromethanopterin
C01300 6-(Hydroxymethyl)-7,8-dihydropterin
C01304 2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C03684 6-Pyruvoyltetrahydropterin
C04244 6-Lactoyl-5,6,7,8-tetrahydropterin
C04807 6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04895 7,8-Dihydroneopterin 3'-triphosphate
C05922 Formamidopyrimidine nucleoside triphosphate
C05923 2,5-Diaminopyrimidine nucleoside triphosphate
C05925 Dihydroneopterin phosphate
C05927 7,8-Dihydromethanopterin
C06148 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C11355 4-Amino-4-deoxychorismate
C15522 4a-Hydroxytetrahydrobiopterin
C16675 7-Aminomethyl-7-carbaguanine
C18237 Molybdoenzyme molybdenum cofactor
C18802 Tetrahydrosarcinapterin
C19848 Adenylated molybdopterin
C19871 Guanylyl molybdenum cofactor
C20239 6-Carboxy-5,6,7,8-tetrahydropterin
C20248 7-Carboxy-7-carbaguanine
C20264 L-threo-Tetrahydrobiopterin
C20559 4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562 N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566 7,8-Dihydroneopterin 2'-phosphate
C20567 7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007 5,6,7,8-Tetrahydromonapterin
C21065 7,8-Dihydroxanthopterin
C21094 7,8-Dihydromonapterin 3'-triphosphate
C21107 4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310 (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485 Cytidylyl molybdenum cofactor
C21486 Thio-molybdenum cofactor
C21640 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Schwarz G, Mendel RR, Ribbe MW
Title
Molybdenum cofactors, enzymes and pathways.
Journal
Reference
Authors
Hanzelmann P, Schindelin H
Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
Journal
Reference
Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
Journal
Reference
Authors
Wuebbens MM, Rajagopalan KV
Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
Journal
Reference
Authors
Werner ER, Blau N, Thony B
Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
Journal
Reference
Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
Journal
Reference
Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
Journal
Related pathway
tim00400 Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
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