KEGG   PATHWAY: trr03008
Entry
trr03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Trichoderma reesei RUT C-30
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
trr03008  Ribosome biogenesis in eukaryotes
trr03008

Organism
Trichoderma reesei RUT C-30 [GN:trr]
Gene
M419DRAFT_125336  casein kinase II regulatory subunit [KO:K03115]
M419DRAFT_99228  hypothetical protein [KO:K03115]
M419DRAFT_37852  casein kinase II [KO:K03097] [EC:2.7.11.1]
M419DRAFT_141892  casein kinase II, alpha chain [KO:K03097] [EC:2.7.11.1]
M419DRAFT_35147  Nrap protein [KO:K14544]
M419DRAFT_80331  putative ribosomal small subunit assembly protein [KO:K14545]
M419DRAFT_93264  NUC189-domain-containing protein [KO:K14546]
M419DRAFT_112322  WD40 repeat-like protein [KO:K14548]
M419DRAFT_81479  putative small nucleolar ribonucleo protein complex subunit Utp15 [KO:K14549]
M419DRAFT_71860  hypothetical protein [KO:K14550]
M419DRAFT_82914  WD40 repeat-like protein [KO:K14552]
M419DRAFT_126991  WD domain-containing protein [KO:K14554]
M419DRAFT_84564  WD40 repeat-like protein [KO:K14555]
M419DRAFT_23890  WD domain-containing protein [KO:K14556]
M419DRAFT_98324  hypothetical protein [KO:K14557]
M419DRAFT_90159  periodic tryptophan protein 2 [KO:K14558]
M419DRAFT_43217  Mpp10 protein [KO:K14559]
M419DRAFT_103128  U3 small nucleolar ribonucleo protein IMP3 [KO:K14560]
M419DRAFT_36155  Brix-domain-containing protein [KO:K14561]
M419DRAFT_86008  Fibrillarin [KO:K14563] [EC:2.1.1.-]
M419DRAFT_115146  putative pre-rRNA processing nucleolar protein Sik1 [KO:K14564]
M419DRAFT_111326  nucleolar protein NOP58-like protein [KO:K14565]
M419DRAFT_127441  snRNP and snoRNP protein [KO:K12845]
M419DRAFT_25869  putative rRNA pseudouridine synthase [KO:K11131] [EC:5.4.99.-]
M419DRAFT_104940  L30e-like protein [KO:K11129]
M419DRAFT_41068  hypothetical protein [KO:K11128]
M419DRAFT_7524  H/ACA ribonucleo protein complex subunit 3 [KO:K11130]
M419DRAFT_101766  FCF1 small subunit [KO:K14566]
M419DRAFT_82901  Utp14-domain-containing protein [KO:K14567]
M419DRAFT_69474  ribonuclease III [KO:K03685] [EC:3.1.26.3]
M419DRAFT_106196  nucleolar essential protein 1 [KO:K14568] [EC:2.1.1.260]
M419DRAFT_134121  DUF663-domain-containing protein [KO:K14569]
M419DRAFT_137730  DUF699-domain-containing protein [KO:K14521] [EC:2.3.1.-]
M419DRAFT_6236  RNA-3'-phosphate cyclase family protein [KO:K11108]
M419DRAFT_7354  hypothetical protein [KO:K01164] [EC:3.1.26.5]
M419DRAFT_87288  hypothetical protein [KO:K14522] [EC:3.1.26.5]
M419DRAFT_23316  RNase P/MRP, p29 subunit [KO:K03538] [EC:3.1.26.5]
M419DRAFT_79515  hypothetical protein [KO:K03537] [EC:3.1.26.5]
M419DRAFT_138774  hypothetical protein [KO:K14526] [EC:3.1.26.5]
M419DRAFT_90135  hypothetical protein [KO:K14528] [EC:3.1.26.5]
M419DRAFT_65803  PHP domain-like protein [KO:K03539] [EC:3.1.26.5]
M419DRAFT_92040  hypothetical protein [KO:K14532]
M419DRAFT_89943  ribonuclease P 40kDa subunit [KO:K14530] [EC:3.1.26.5]
M419DRAFT_78663  hypothetical protein [KO:K14570] [EC:3.1.-.-]
M419DRAFT_25353  exonuclease [KO:K14570] [EC:3.1.-.-]
M419DRAFT_92555  hypothetical protein [KO:K14570] [EC:3.1.-.-]
M419DRAFT_72115  oligoribonuclease [KO:K13288] [EC:3.1.-.-]
M419DRAFT_39052  P-loop containing nucleoside triphosphate hydrolase protein [KO:K06943]
M419DRAFT_94865  NGP1NT-domain-containing protein [KO:K14537]
M419DRAFT_36248  hypothetical protein [KO:K14538]
M419DRAFT_38065  AAA-domain-containing protein [KO:K14571]
M419DRAFT_104679  RNA-binding domain-containing protein [KO:K14573]
M419DRAFT_24453  D-site 20S pre-rRNA nuclease [KO:K11883]
M419DRAFT_36946  casein kinase I isoform epsilon [KO:K14758] [EC:2.7.11.1]
M419DRAFT_136136  GTP-binding nuclear protein GSP1/Ran [KO:K07936]
M419DRAFT_80626  hypothetical protein [KO:K14290]
M419DRAFT_127069  nonsense-mediated mRNA decay protein 3 [KO:K07562]
M419DRAFT_125686  NTF2-like protein [KO:K14284]
M419DRAFT_76488  nuclear transport factor 2 domain-containing protein [KO:K14285]
M419DRAFT_103331  eukaryotic translation initiation factor 6 [KO:K03264]
M419DRAFT_122548  Shwachman-Bodian-diamond syndrome protein [KO:K14574]
M419DRAFT_99875  ribosome biogenesis protein Ria1 [KO:K14536] [EC:3.6.5.-]
M419DRAFT_132091  putative ribosome biogenesis GTPase Lsg1 [KO:K14539] [EC:3.6.1.-]
M419DRAFT_7378  AAA family ATPase [KO:K14575]
M419DRAFT_102036  P-loop containing nucleoside triphosphate hydrolase protein [KO:K18532] [EC:2.7.4.3]
M419DRAFT_139310  Serine/threonine-protein kinase Rio1 [KO:K07178] [EC:2.7.11.1]
M419DRAFT_71082  RIO1-domain-containing protein [KO:K07179] [EC:2.7.11.1]
Reference
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
trr03010  Ribosome
KO pathway
ko03008   
LinkDB

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