KEGG   PATHWAY: pfs00350
Entry
pfs00350                    Pathway                                
Name
Tyrosine metabolism - Pseudomonas fluorescens SBW25
Class
Metabolism; Amino acid metabolism
Pathway map
pfs00350  Tyrosine metabolism
pfs00350

Module
pfs_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:pfs00350]
pfs_M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:pfs00350]
Other DBs
GO: 0006570
Organism
Pseudomonas fluorescens SBW25 [GN:pfs]
Gene
PFLU_4027  Aminotransferase (EC [KO:K00812] [EC:2.6.1.1]
PFLU_3176  Aminotransferase (EC [KO:K00812] [EC:2.6.1.1]
PFLU_4293  Aminotransferase (EC [KO:K00812] [EC:2.6.1.1]
PFLU_2233  Aminotransferase (EC [KO:K00812] [EC:2.6.1.1]
PFLU_4460  Aspartate aminotransferase [KO:K00813] [EC:2.6.1.1]
PFLU_5135  Putative aminotransferase [KO:K00817] [EC:2.6.1.9]
PFLU_0897  Histidinol-phosphate aminotransferase (EC (Imidazole acetol-phosphate transaminase) [KO:K00817] [EC:2.6.1.9]
PFLU_1646  hisC; Histidinol-phosphate aminotransferase (EC (Imidazole acetol-phosphate transaminase) [KO:K00817] [EC:2.6.1.9]
PFLU_4209  Aminotransferase (EC [KO:K00832] [EC:2.6.1.57]
PFLU_2997  Putative 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
PFLU_1025  hmgA; Homogentisate 1,2-dioxygenase (HGDO) (EC (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase) [KO:K00451] [EC:1.13.11.5]
PFLU_1027  Putative maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
PFLU_1026  Fumarylacetoacetase (EC (Fumarylacetoacetate hydrolase) [KO:K01555] [EC:3.7.1.2]
PFLU_1951  Putative fumarylacetoacetate hydrolase family protein [KO:K16171] [EC:3.7.1.2]
PFLU_4065  Putative oxidase [KO:K00274] [EC:1.4.3.4]
PFLU_3070  Putative FAD dependent oxidoreductase [KO:K25271] [EC:1.4.3.-]
PFLU_3072  Putative ornithine cyclodeaminase [KO:K25272] [EC:1.4.3.-]
PFLU_3291  Putative aldehyde dehydrogenase [KO:K00146] [EC:1.2.1.39]
PFLU_3086  Putative phenylacetaldehyde dehydrogenase (EC [KO:K00146] [EC:1.2.1.39]
PFLU_3097  Putative phenylacetaldehyde dehydrogenase [KO:K00146] [EC:1.2.1.39]
PFLU_1295  adhC; Alcohol dehydrogenase class III [KO:K00121] [EC:1.1.1.284 1.1.1.1]
PFLU_1412  Probable alcohol dehydrogenase (EC [KO:K13954] [EC:1.1.1.1]
PFLU_4115  Putative alcohol dehydrogenase (EC [KO:K00001] [EC:1.1.1.1]
PFLU_3290  Putative oxidoreductase (EC [KO:K23492] [EC:1.14.14.9]
PFLU_3289  Flavin_Reduct domain-containing protein [KO:K23470] [EC:1.5.1.36]
PFLU_3272  3,4-dihydroxyphenylacetate 2,3-dioxygenase (EC [KO:K00455] [EC:1.13.11.15]
PFLU_3271  5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (EC [KO:K00151] [EC:1.2.1.60]
PFLU_1499  Uncharacterized protein [KO:K01826] [EC:5.3.3.10]
PFLU_3273  6 5-carboxymethyl-2-hydroxymuconate delta-isomerase [KO:K01826] [EC:5.3.3.10]
PFLU_2285  Putative muconate delta-isomerase [KO:K01826] [EC:5.3.3.10]
PFLU_3269  Fumarylacetoacetate (FAA) hydrolase family protein [KO:K05921] [EC:4.1.1.68 5.3.3.-]
PFLU_3270  Putative 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (EC [KO:K05921] [EC:4.1.1.68 5.3.3.-]
PFLU_3275  6 2-oxo-hepta-3-ene-1,7-dioic acid hydratase [KO:K02509] [EC:4.2.1.-]
PFLU_3276  2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (EC [KO:K02510] [EC:4.1.2.52]
PFLU_4039  Putative succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_1938  gabD2; Succinate-semialdehyde dehydrogenase (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_0180  gabD; Succinate-semialdehyde dehydrogenase [NADP+] (EC [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
PFLU_2602  Putative fumarylpyruvate hydrolase [KO:K16165] [EC:3.7.1.20]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
pfs00020  Citrate cycle (TCA cycle)
pfs00360  Phenylalanine metabolism
pfs00400  Phenylalanine, tyrosine and tryptophan biosynthesis
pfs00620  Pyruvate metabolism
pfs00650  Butanoate metabolism
KO pathway
ko00350   
LinkDB

DBGET integrated database retrieval system