KEGG   PATHWAY: pset02010
Entry
pset02010                   Pathway                                
Name
ABC transporters - Pseudomonas sp. TCU-HL1
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
pset02010  ABC transporters
pset02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Pseudomonas sp. TCU-HL1 [GN:pset]
Gene
THL1_1040  [KO:K12372]
THL1_1041  [KO:K12371]
THL1_1043  [KO:K12370]
THL1_1044  [KO:K12369]
THL1_1045  [KO:K12368]
THL1_1048  [KO:K12368]
THL1_1049  [KO:K12368]
THL1_1074  [KO:K06861] [EC:7.5.2.5]
THL1_1079  [KO:K02065]
THL1_1080  [KO:K02066]
THL1_1081  [KO:K02067]
THL1_1082  [KO:K07323]
THL1_1083  [KO:K07122]
THL1_1171  [KO:K07091]
THL1_1172  [KO:K11720]
THL1_1275  [KO:K10022]
THL1_1276  [KO:K09972] [EC:7.4.2.1]
THL1_1277  [KO:K09971]
THL1_1278  [KO:K09970]
THL1_1279  [KO:K09969]
THL1_132  [KO:K02045] [EC:7.3.2.3]
THL1_133  [KO:K02047]
THL1_134  [KO:K02046]
THL1_1347  [KO:K02020]
THL1_135  [KO:K23163]
THL1_1474  [KO:K11073]
THL1_1523  [KO:K17315]
THL1_1524  [KO:K17316]
THL1_1525  [KO:K17317]
THL1_1526  [KO:K10112] [EC:7.5.2.-]
THL1_1543  [KO:K01996]
THL1_1544  [KO:K01995]
THL1_1545  [KO:K01998]
THL1_1546  [KO:K01997]
THL1_1547  [KO:K01999]
THL1_158  [KO:K10010] [EC:7.4.2.1]
THL1_159  [KO:K10009]
THL1_1591  [KO:K10036]
THL1_1592  [KO:K10037]
THL1_1593  [KO:K10038] [EC:7.4.2.1]
THL1_160  [KO:K02424]
THL1_162  [KO:K02073]
THL1_1709  [KO:K01996]
THL1_1710  [KO:K01995]
THL1_1711  [KO:K01998]
THL1_1712  [KO:K01997]
THL1_1713  [KO:K01999]
THL1_1716  [KO:K02042]
THL1_1717  [KO:K02042]
THL1_1718  [KO:K02041] [EC:7.3.2.2]
THL1_1719  [KO:K02044]
THL1_172  [KO:K15552]
THL1_173  [KO:K10831] [EC:7.6.2.7]
THL1_1733  [KO:K18893]
THL1_174  [KO:K15551]
THL1_1765  [KO:K24821]
THL1_177  [KO:K15553]
THL1_179  [KO:K15554]
THL1_180  [KO:K15555] [EC:7.6.2.14]
THL1_185  [KO:K11073]
THL1_1855  [KO:K11073]
THL1_1865  [KO:K11073]
THL1_1881  [KO:K12541]
THL1_190  [KO:K11073]
THL1_191  [KO:K11073]
THL1_192  [KO:K11076] [EC:7.6.2.16]
THL1_193  [KO:K11075]
THL1_194  [KO:K11074]
THL1_2153  [KO:K09808]
THL1_2154  [KO:K09810] [EC:7.6.2.-]
THL1_2155  [KO:K09808]
THL1_234  [KO:K09812]
THL1_235  [KO:K09811]
THL1_2624  [KO:K15578] [EC:7.3.2.4]
THL1_2625  [KO:K15577]
THL1_2626  [KO:K15576]
THL1_269  [KO:K02424]
THL1_2723  [KO:K11069]
THL1_2724  [KO:K11070]
THL1_2725  [KO:K11071]
THL1_2726  [KO:K11072] [EC:7.6.2.11]
THL1_277  [KO:K11069]
THL1_278  [KO:K11070]
THL1_279  [KO:K11071]
THL1_280  [KO:K11072] [EC:7.6.2.11]
THL1_2873  [KO:K02471]
THL1_29  [KO:K02002]
THL1_2931  [KO:K11073]
THL1_2939  [KO:K02000] [EC:7.6.2.9]
THL1_2940  [KO:K02001]
THL1_2941  [KO:K02002]
THL1_2951  [KO:K10022]
THL1_2967  [KO:K10014]
THL1_2968  [KO:K10016]
THL1_2969  [KO:K10015]
THL1_2970  [KO:K10017] [EC:7.4.2.1]
THL1_3119  [KO:K11073]
THL1_3159  [KO:K02040]
THL1_3341  [KO:K11070 K11071]
THL1_3343  [KO:K11069]
THL1_3373  [KO:K11004]
THL1_342  [KO:K02002]
THL1_343  [KO:K02002]
THL1_344  [KO:K02001]
THL1_345  [KO:K02000] [EC:7.6.2.9]
THL1_346  [KO:K02002]
THL1_3464  [KO:K11073]
THL1_3543  [KO:K01995]
THL1_3544  [KO:K01996]
THL1_3545  [KO:K01999]
THL1_3546  [KO:K01997]
THL1_3547  [KO:K01998]
THL1_362  [KO:K02002]
THL1_3633  [KO:K13893]
THL1_3634  [KO:K13893]
THL1_3635  [KO:K13894]
THL1_3636  [KO:K13895]
THL1_3637  [KO:K13896]
THL1_3835  [KO:K10001]
THL1_3836  [KO:K10003]
THL1_3837  [KO:K10002]
THL1_3838  [KO:K10004] [EC:7.4.2.1]
THL1_385  [KO:K11069]
THL1_386  [KO:K11071]
THL1_3868  [KO:K11073]
THL1_387  [KO:K11070]
THL1_388  [KO:K11072] [EC:7.6.2.11]
THL1_3916  [KO:K02048]
THL1_3929  [KO:K02196]
THL1_3930  [KO:K02195]
THL1_3931  [KO:K02194]
THL1_3932  [KO:K02193] [EC:7.6.2.5]
THL1_4007  [KO:K11073]
THL1_4105  [KO:K02012]
THL1_4106  [KO:K02011]
THL1_4107  [KO:K02010] [EC:7.2.2.7]
THL1_4291  [KO:K10025] [EC:7.4.2.1]
THL1_4293  [KO:K10023]
THL1_4294  [KO:K10024]
THL1_4295  [KO:K10022]
THL1_4338  [KO:K12541]
THL1_4358  [KO:K02017] [EC:7.3.2.5]
THL1_4359  [KO:K02018]
THL1_4374  [KO:K02010] [EC:7.2.2.7]
THL1_4397  [KO:K12536]
THL1_4426  [KO:K02002]
THL1_455  [KO:K11073]
THL1_465  [KO:K11069]
THL1_466  [KO:K11070]
THL1_467  [KO:K11071]
THL1_468  [KO:K11072] [EC:7.6.2.11]
THL1_4953  [KO:K11069]
THL1_4954  [KO:K11072] [EC:7.6.2.11]
THL1_4955  [KO:K11071]
THL1_4956  [KO:K11070]
THL1_5146  [KO:K11959]
THL1_5147  [KO:K11960]
THL1_5148  [KO:K11961]
THL1_5149  [KO:K11962]
THL1_5150  [KO:K11963]
THL1_5174  [KO:K01996]
THL1_5175  [KO:K01995]
THL1_5176  [KO:K01998]
THL1_5177  [KO:K01997]
THL1_5178  [KO:K01999]
THL1_5258  [KO:K11085] [EC:7.5.2.6]
THL1_5345  [KO:K02000] [EC:7.6.2.9]
THL1_5346  [KO:K02001]
THL1_5347  [KO:K02002]
THL1_5350  [KO:K02002]
THL1_5412  [KO:K23058]
THL1_5413  [KO:K23055]
THL1_5414  [KO:K23056]
THL1_5415  [KO:K23057]
THL1_5492  [KO:K02011]
THL1_5493  [KO:K02012]
THL1_5612  [KO:K12368]
THL1_5654  [KO:K02036] [EC:7.3.2.1]
THL1_5655  [KO:K02038]
THL1_5656  [KO:K02037]
THL1_5657  [KO:K02040]
THL1_60  [KO:K02073]
THL1_61  [KO:K02072]
THL1_62  [KO:K02071]
THL1_65  [KO:K09816]
THL1_66  [KO:K09817] [EC:7.2.2.20]
THL1_68  [KO:K09815]
THL1_779  [KO:K06858]
THL1_906  [KO:K11072] [EC:7.6.2.11]
THL1_907  [KO:K11069]
THL1_908  [KO:K11071]
THL1_909  [KO:K11070]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   

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