KEGG   PATHWAY: pvp03013
Entry
pvp03013                    Pathway                                
Name
Nucleocytoplasmic transport - Pteropus vampyrus (large flying fox)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pvp03013  Nucleocytoplasmic transport
pvp03013

Other DBs
GO: 0050658
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288481  XPO5; exportin-5 isoform X1 [KO:K14289]
105289009  [KO:K14316]
105289434  NUP43; nucleoporin Nup43 [KO:K14305]
105289710  NUP35; nucleoporin NUP53 isoform X1 [KO:K14313]
105290076  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
105290191  TNPO3; transportin-3 isoform X1 [KO:K15436]
105290469  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105290565  KPNA6; importin subunit alpha-7 isoform X3 [KO:K15042]
105290666  [KO:K03231]
105290881  PHAX; phosphorylated adapter RNA export protein isoform X2 [KO:K14291]
105290988  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
105291630  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
105291705  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
105291781  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
105292037  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
105292146  XPO4; exportin-4 [KO:K25203]
105292286  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
105292359  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
105292577  AHCTF1; protein ELYS isoform X1 [KO:K25129]
105293155  NUPL2; nucleoporin-like protein 2 [KO:K14321]
105293346  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
105293347  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
105293597  [KO:K07936]
105293637  KPNA7; importin subunit alpha-8 [KO:K15043]
105293884  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
105293934  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
105294087  IPO8; importin-8 [KO:K18755]
105294155  IPO5; importin-5 [KO:K20222]
105294588  THOC3; THO complex subunit 3 [KO:K12880]
105294634  [KO:K14290]
105294798  [KO:K14311]
105294810  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
105294982  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
105295054  TPR; nucleoprotein TPR [KO:K09291]
105295199  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
105296073  CSE1L; exportin-2 [KO:K18423]
105296132  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
105296149  [KO:K12883]
105296237  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
105296403  POM121L2; POM121-like protein 2 [KO:K14316]
105296458  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
105296548  XPO7; exportin-7 [KO:K18460]
105296581  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105296943  IPO9; importin-9 [KO:K20224]
105297096  IPO13; importin-13 isoform X1 [KO:K25202]
105297709  KPNA2; importin subunit alpha-1 [KO:K15043]
105297818  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
105298097  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
105298114  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
105298687  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
105298779  RAE1; mRNA export factor [KO:K14298]
105298873  KPNA3; importin subunit alpha-4 [KO:K23583]
105298892  KPNA1; importin subunit alpha-5 [KO:K23940]
105298966  NDC1; nucleoporin NDC1 isoform X2 [KO:K14315]
105298967  MAGOH; protein mago nashi homolog [KO:K12877]
105299081  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
105299295  RANBP17; ran-binding protein 17 [KO:K24115]
105299564  RAN; GTP-binding nuclear protein Ran [KO:K07936]
105299687  [KO:K14316]
105300493  TNPO1; transportin-1 isoform X1 [KO:K18752]
105300533  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
105300928  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
105301097  XPOT; exportin-T isoform X1 [KO:K14288]
105301169  ALYREF; THO complex subunit 4 [KO:K12881]
105301461  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
105301584  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
105301783  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
105302034  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
105302169  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
105302318  [KO:K12172] [EC:2.3.2.-]
105302440  NUP58; nucleoporin p58/p45 [KO:K14307]
105302602  PYM1; partner of Y14 and mago [KO:K14294]
105302657  AAAS; aladin isoform X1 [KO:K14320]
105302816  NXT1; NTF2-related export protein 1 [KO:K14285]
105303022  PNN; pinin [KO:K13114]
105303029  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
105303126  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
105303293  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
105303350  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X2 [KO:K14325]
105303537  IPO7; importin-7 isoform X1 [KO:K20223]
105303618  IPO11; importin-11 isoform X1 [KO:K25201]
105303668  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105304243  THOC2; THO complex subunit 2 isoform X6 [KO:K12879]
105304589  XPO6; exportin-6 isoform X1 [KO:K25204]
105305090  UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A [KO:K14328]
105305224  EIF4A3; eukaryotic initiation factor 4A-III isoform X1 [KO:K13025] [EC:5.6.2.7]
105305231  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
105305285  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
105305330  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
105305557  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
105305826  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
105306065  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
105306114  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
105306361  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
105306856  SNUPN; snurportin-1 [KO:K13151]
105306862  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
105307161  TNPO2; transportin-2 isoform X1 [KO:K18727]
105307273  KPNB1; importin subunit beta-1 [KO:K14293]
105307456  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
105307518  CASC3; protein CASC3 [KO:K14323]
105307983  [KO:K12877]
105308073  NXF5; nuclear RNA export factor 5 [KO:K14284]
105308400  [KO:K14290]
105308790  NUP133; LOW QUALITY PROTEIN: nuclear pore complex protein Nup133 [KO:K14300]
105309021  [KO:K03231]
105309382  IPO4; importin-4 isoform X1 [KO:K20221]
105310169  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
105310670  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
105310675  NUP37; nucleoporin Nup37 [KO:K14302]
105310788  [KO:K14284]
111731794  [KO:K18655] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pvp03015  mRNA surveillance pathway
KO pathway
ko03013   

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