KEGG   PATHWAY: pvp04980
Entry
pvp04980                    Pathway                                
Name
Cobalamin transport and metabolism - Pteropus vampyrus (large flying fox)
Class
Organismal Systems; Digestive system
Pathway map
pvp04980  Cobalamin transport and metabolism
pvp04980

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288579  MUT; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
105291556  MMAA; methylmalonic aciduria type A protein, mitochondrial isoform X1 [KO:K07588] [EC:3.6.5.-]
105291616  MMADHC; methylmalonic aciduria and homocystinuria type D protein, mitochondrial isoform X1 [KO:K26006]
105292804  LMBRD1; probable lysosomal cobalamin transporter [KO:K14617]
105297129  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
105297130  MMACHC; methylmalonic aciduria and homocystinuria type C protein isoform X1 [KO:K14618] [EC:1.16.1.6 2.5.1.151]
105299266  ABCD4; LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 4 [KO:K05678] [EC:7.6.2.8]
105299590  MTRR; methionine synthase reductase isoform X2 [KO:K00597] [EC:1.16.1.8]
105300904  TCN2; transcobalamin-2 [KO:K14619]
105301021  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
105302488  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
105302733  MTR; methionine synthase [KO:K00548] [EC:2.1.1.13]
105303538  ZNF143; zinc finger protein 143 isoform X1 [KO:K20828]
105303945  MMAB; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial isoform X1 [KO:K00798] [EC:2.5.1.17]
105305031  TCN1; LOW QUALITY PROTEIN: transcobalamin-1 [KO:K25741]
105305052  GIF; gastric intrinsic factor [KO:K14615]
105305734  THAP11; THAP domain-containing protein 11 [KO:K23211]
105307709  CD320; CD320 antigen [KO:K06734]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews (1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
pvp00270  Cysteine and methionine metabolism
pvp00280  Valine, leucine and isoleucine degradation
pvp00670  One carbon pool by folate
pvp04144  Endocytosis
pvp04977  Vitamin digestion and absorption
KO pathway
ko04980   

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