KEGG   PATHWAY: pyu04721
Entry
pyu04721                    Pathway                                
Name
Synaptic vesicle cycle - Puma yagouaroundi (jaguarundi)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
pyu04721  Synaptic vesicle cycle
pyu04721

Other DBs
GO: 0016079 0048488
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010405  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
121010444  STX2; syntaxin-2 isoform X1 [KO:K08486]
121010919  SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
121011004  RAB3A; ras-related protein Rab-3A [KO:K07882]
121011121  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
121011281  UNC13A; protein unc-13 homolog A [KO:K15293]
121011313  CPLX2; complexin-2 [KO:K15294]
121011434  CLTB; clathrin light chain B isoform X1 [KO:K04645]
121012204  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
121012485  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
121013698  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
121013989  DNM2; dynamin-2 isoform X1 [KO:K23484]
121014070  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121015029  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
121015748  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
121016331  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
121017109  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
121017266  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
121017728  STX1A; syntaxin-1A isoform X1 [KO:K04560]
121018667  AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
121018692  NAPA; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
121018773  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
121018795  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
121019090  [KO:K02151]
121019276  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
121019667  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
121020158  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
121020286  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121021922  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
121022068  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
121022131  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
121022174  STX1B; syntaxin-1B [KO:K08486]
121022356  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
121022422  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
121022799  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
121023312  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
121023776  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
121027000  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
121027001  SLC6A9; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 1 [KO:K05038]
121027144  SLC1A7; excitatory amino acid transporter 5 isoform X1 [KO:K05618]
121028133  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
121028270  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
121028368  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
121029661  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
121031937  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
121032866  CPLX4; complexin-4 [KO:K15295]
121034075  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
121034628  UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293]
121034669  CLTA; clathrin light chain A isoform X1 [KO:K04644]
121034879  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
121035022  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
121035055  DNM1; LOW QUALITY PROTEIN: dynamin-1 [KO:K01528] [EC:3.6.5.5]
121036251  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121036933  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
121037280  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
121038033  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
121038266  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
121039703  CPLX1; complexin-1 isoform X1 [KO:K15294]
121039906  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
121039995  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
121040552  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
121040704  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
121041258  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
121041260  SLC6A11; sodium- and chloride-dependent GABA transporter 3 isoform X1 [KO:K05044]
121041730  UNC13C; protein unc-13 homolog C isoform X1 [KO:K15293]
121041997  CPLX3; complexin-3 [KO:K15295]
121042818  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
121043371  STX3; syntaxin-3 [KO:K08486]
121043545  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
121043568  SLC1A3; excitatory amino acid transporter 1 [KO:K05614]
121043650  SLC17A6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
121043656  SLC6A5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
121044095  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
121044693  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
121045028  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
121045040  SLC6A7; sodium-dependent proline transporter isoform X1 [KO:K05040]
121045322  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
121045454  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
pyu04144  Endocytosis
pyu04724  Glutamatergic synapse
pyu04725  Cholinergic synapse
pyu04726  Serotonergic synapse
pyu04727  GABAergic synapse
pyu04728  Dopaminergic synapse
KO pathway
ko04721   

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