KEGG   PATHWAY: pyu04726
Entry
pyu04726                    Pathway                                
Name
Serotonergic synapse - Puma yagouaroundi (jaguarundi)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
pyu04726  Serotonergic synapse
pyu04726

Other DBs
GO: 0007210
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010357  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
121010546  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
121011080  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121011233  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121011859  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121011861  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
121012476  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012479  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012964  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
121013601  [KO:K04634]
121014032  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
121014070  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014449  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015334  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
121015443  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
121015960  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
121015961  ALOX15B; polyunsaturated fatty acid lipoxygenase ALOX15B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
121016040  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1 [KO:K00458] [EC:1.13.11.31]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121017001  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
121017266  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
121017640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121018664  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121019302  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121019755  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121019943  [KO:K04632]
121019944  [KO:K04632]
121020286  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121021435  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121021966  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022967  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
121022974  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023145  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
121023937  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
121023990  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
121025703  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026111  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
121026118  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
121027070  [KO:K07428] [EC:1.14.14.1]
121027220  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
121027288  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027385  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121027636  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121027738  NRAS; GTPase NRas [KO:K07828]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028429  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
121028731  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121028732  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
121028803  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121029298  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121029688  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
121029748  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
121030451  [KO:K04161]
121030576  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
121031761  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121033767  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
121034022  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
121034069  HTR3D; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3D [KO:K04819]
121034072  [KO:K04819]
121034230  HTR3C; 5-hydroxytryptamine receptor 3C [KO:K04819]
121034231  [KO:K04819]
121034834  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121034945  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
121035407  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
121035466  [KO:K04540]
121035634  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
121035941  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
121036049  [KO:K04520]
121036108  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
121036230  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
121036524  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121036944  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
121036980  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
121037024  [KO:K07413] [EC:1.14.14.1]
121037025  [KO:K07413] [EC:1.14.14.1]
121037280  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
121038668  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
121038795  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121039672  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121039995  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
121040241  [KO:K07414] [EC:1.14.14.1]
121040737  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041326  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121041495  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121041554  [KO:K16342] [EC:3.1.1.4]
121041557  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
121041559  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
121041561  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121041716  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121042545  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
121043698  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
121044748  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
121044824  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
121045329  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
pyu00380  Tryptophan metabolism
pyu00590  Arachidonic acid metabolism
pyu04020  Calcium signaling pathway
pyu04721  Synaptic vesicle cycle
pyu04976  Bile secretion
KO pathway
ko04726   

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