| Entry |
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| Name |
Glycerophospholipid metabolism |
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| Class |
Metabolism; Lipid metabolism
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| Pathway map |
| rn00564 | Glycerophospholipid metabolism |
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| Module |
| M00090 | Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:rn00564] |
| M00091 | Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:rn00564] |
| M00092 | Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:rn00564] |
| M00093 | Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:rn00564] |
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| Other DBs |
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| Reaction |
| R00748 | ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming) |
| R00749 | ethanolamine ammonia-lyase (acetaldehyde-forming) |
| R00842 | sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase |
| R00844 | sn-glycerol-3-phosphate:NADP+ 2-oxidoreductase |
| R00846 | sn-glycerol-3-phosphate:oxygen 2-oxidoreductase |
| R00848 | sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase |
| R00851 | acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase |
| R00855 | CDPglycerol phosphoglycerohydrolase |
| R00856 | CTP:sn-glycerol-3-phosphate cytidylyltransferase |
| R01013 | acyl-CoA:glycerone-phosphate O-acyltransferase |
| R01021 | ATP:choline phosphotransferase |
| R01023 | acetyl-CoA:choline O-acetyltransferase |
| R01026 | acetylcholine aectylhydrolase |
| R01030 | sn-glycero-3-phosphocholine glycerophosphohydrolase |
| R01310 | phosphatidylcholine phosphatidohydrolase |
| R01312 | phosphatidylcholine cholinephosphohydrolase |
| R01315 | phosphatidylcholine 2-acylhydrolase |
| R01316 | phosphatidylcholine 1-acylhydrolase |
| R01318 | acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase |
| R01319 | acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase |
| R01320 | S-adenosyl-L-methionine:phosphatidyl-N-dimethylethanolamine N-methyltransferase |
| R01321 | CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase |
| R01468 | ATP:ethanolamine O-phosphotransferase |
| R01470 | sn-glycero-3-phosphoethanolamine glycerophosphohydrolase |
| R01797 | CDP-diacylglycerol phosphatidylhydrolase |
| R01799 | CTP:phosphatidate cytidyltransferase |
| R01800 | CDP-diacylglycerol:L-serine 3-phosphatidyltransferase |
| R01801 | CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase |
| R01802 | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase |
| R01890 | CTP:choline-phosphate cytidylyltransferase |
| R02027 | phosphatidylglycerol cholinephosphohydrolase |
| R02029 | phosphatidylglycerophosphate phosphohydrolase |
| R02030 | CDP-diacylglycerol:phosphatidylglycerol 3-phosphatidyltransferase |
| R02037 | S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase |
| R02038 | CTP:ethanolamine-phosphate cytidylyltransferase |
| R02051 | phosphatidylethanolamine phosphatidohydrolase |
| R02052 | phosphatidylethanolamine ethanolaminephosphohydrolase |
| R02053 | phosphatidylethanolamine 2-acylhydrolase |
| R02054 | phosphatidylethanolamine 1-acylhydrolase |
| R02055 | phsophatidyl-L-serine carboxy-lyase |
| R02056 | S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase |
| R02057 | CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase |
| R02114 | phosphatidylcholine:sterol O-acyltransferase |
| R02239 | 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase |
| R02240 | ATP:1,2-diacylglycerol 3-phosphotransferase |
| R02241 | acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase |
| R02242 | acyl-CoA:2-acyl-sn-glycerol-3-phosphate O-acyltransferase |
| R02563 | CDPethanolamine:L-serine ethanolaminephosphotransferase |
| R02746 | 1-acyl-sn-glycero-3-phosphocholine acylhydrolase |
| R02747 | 2-acyl-sn-glycero-3-phosphocholine acylhydrolase |
| R02817 | serine-phosphoethanolamine ethanolaminephosphohydrolase |
| R03360 | 1-phosphatidyl-D-myo-inositol 2-acylhydrolase |
| R03416 | 1-acyl-sn-glycero-3-phosphoethanolamine aldehydohydrolase |
| R03417 | L-2-lysophosphatidylethanolamine aldehydohydrolase |
| R03424 | S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase |
| R04034 | 3-sn-phosphatidyl-L-serine sn-1 acylhydrolase |
| R04158 | geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase |
| R04480 | acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase |
| R04520 | geranylgeranyl-diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase |
| R04864 | 2-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase |
| R05381 | diethanolamine ethanolamine-lyase (acetaldehyde-forming) |
| R05382 | triethanolamine diethanolamine-lyase (acetaldehyde-forming) |
| R05679 | sn-glycerol-1-phosphate:NAD 2-oxidoreductase |
| R05680 | sn-glycerol-1-phosphate:NADP 2-oxidoreductase |
| R05794 | CDP-diacylglycerol:choline O-phosphatidyltransferase |
| R06868 | S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase |
| R06869 | S-adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase |
| R06870 | phosphoethanolamine phosphohydrolase |
| R06871 | phosphocholine phosphohydrolase |
| R06872 | acyl-CoA:sn-glycerol-3-phosphate 2-O-acyltransferase |
| R07376 | L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase |
| R08966 | CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol-1-phosphate cytidylyltransferase |
| R09034 | acyl-CoA:1-acyl-sn-glycero-3-phosphoinositol O-acyltransferase |
| R09035 | acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase |
| R09036 | acyl-CoA:1-acyl-sn-glycero-3-phosphoglycerol O-acyltransferase |
| R09038 | cardiolipin acylhydrolase |
| R09072 | S-adenosyl-L-methionine:1,2-diacyl-sn-glycerol 3-amino-3-carboxypropyltransferase |
| R09073 | S-adenosylmethionine:diacylglycerylhomoserine N-methyltransferase (diacylglyceryl-N,N,N-trimethylhomoserine-forming) |
| R09944 | CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase |
| R10255 | CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-(O-geranylgeranyl)-sn-glycerol phosphotransferase |
| R10325 | 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:NAD+ oxidoreductase |
| R10326 | 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:NADP+ oxidoreductase |
| R10331 | 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase |
| R11062 | phosphatidylethanolamine:phosphatidylglycerol 3-phosphatidyltransferase |
| R12241 | acyl phosphoate:sn-glycerol 3-phosphate acyltransferase |
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| Compound |
| C00093 | sn-Glycerol 3-phosphate |
| C00350 | Phosphatidylethanolamine |
| C00623 | sn-Glycerol 1-phosphate |
| C00670 | sn-Glycero-3-phosphocholine |
| C00681 | 1-Acyl-sn-glycerol 3-phosphate |
| C01194 | 1-Phosphatidyl-D-myo-inositol |
| C01210 | N-Methylethanolamine phosphate |
| C01233 | sn-Glycero-3-phosphoethanolamine |
| C01241 | Phosphatidyl-N-methylethanolamine |
| C03372 | Acylglycerone phosphate |
| C03819 | 1-Acylglycerophosphoinositol |
| C03872 | L-Serine-phosphoethanolamine |
| C03892 | Phosphatidylglycerophosphate |
| C03974 | 2-Acyl-sn-glycerol 3-phosphate |
| C04230 | 1-Acyl-sn-glycero-3-phosphocholine |
| C04233 | 2-Acyl-sn-glycero-3-phosphocholine |
| C04308 | Phosphatidyl-N-dimethylethanolamine |
| C04438 | 1-Acyl-sn-glycero-3-phosphoethanolamine |
| C04590 | 3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate |
| C04638 | 2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate |
| C05973 | 2-Acyl-sn-glycero-3-phosphoethanolamine |
| C05974 | 2-Acyl-sn-glycero-3-phosphoserine |
| C05976 | Aminoacyl-phosphatidylglycerol |
| C13482 | Phosphodimethylethanolamine |
| C18059 | CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol |
| C18125 | 1-Acyl-sn-glycero-3-phosphoserine |
| C18126 | 1-Acyl-sn-glycero-3-phosphoglycerol |
| C18168 | Diacylglycerylhomoserine |
| C18169 | Diacylglyceryl-N,N,N-trimethylhomoserine |
| C20466 | 2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine |
| C20518 | 2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate |
| C22340 | Heptaprenylglyceryl phosphate |
| C22342 | Diacetylheptaprenylglycerol |
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| Reference |
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| Authors |
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML. |
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| Title |
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae. |
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| Journal |
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| Reference |
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| Authors |
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M. |
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| Title |
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Athenstaedt K, Daum G. |
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| Title |
Phosphatidic acid, a key intermediate in lipid metabolism. |
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| Journal |
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| Reference |
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| Authors |
Shields DJ, Lehner R, Agellon LB, Vance DE. |
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| Title |
Membrane topography of human phosphatidylethanolamine N-methyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O. |
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| Title |
Pathways for phosphatidylcholine biosynthesis in bacteria. |
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| Journal |
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| Reference |
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| Authors |
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G. |
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| Title |
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. |
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| Journal |
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| Reference |
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| Authors |
Hsu L, Jackowski S, Rock CO |
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| Title |
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity. |
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| Journal |
J Biol Chem 266:13783-8 (1991) |
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| Reference |
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| Authors |
Stone SJ, Vance JE. |
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| Title |
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. |
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| Journal |
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Related
pathway |
| rn00010 | Glycolysis / Gluconeogenesis |
| rn00260 | Glycine, serine and threonine metabolism |
| rn00562 | Inositol phosphate metabolism |
| rn00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis |
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| KO pathway |
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