KEGG   PATHWAY: rn00564
Entry
rn00564                     Pathway                                
Name
Glycerophospholipid metabolism
Class
Metabolism; Lipid metabolism
Pathway map
rn00564  Glycerophospholipid metabolism
rn00564

Module
M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:rn00564]
M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:rn00564]
M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:rn00564]
M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:rn00564]
Other DBs
GO: 0006650
Reaction
R00748  ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming)
R00749  ethanolamine ammonia-lyase (acetaldehyde-forming)
R00842  sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
R00844  sn-glycerol-3-phosphate:NADP+ 2-oxidoreductase
R00846  sn-glycerol-3-phosphate:oxygen 2-oxidoreductase
R00848  sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase
R00851  acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
R00855  CDPglycerol phosphoglycerohydrolase
R00856  CTP:sn-glycerol-3-phosphate cytidylyltransferase
R01013  acyl-CoA:glycerone-phosphate O-acyltransferase
R01021  ATP:choline phosphotransferase
R01023  acetyl-CoA:choline O-acetyltransferase
R01026  acetylcholine aectylhydrolase
R01030  sn-glycero-3-phosphocholine glycerophosphohydrolase
R01310  phosphatidylcholine phosphatidohydrolase
R01312  phosphatidylcholine cholinephosphohydrolase
R01315  phosphatidylcholine 2-acylhydrolase
R01316  phosphatidylcholine 1-acylhydrolase
R01318  acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
R01319  acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase
R01320  S-adenosyl-L-methionine:phosphatidyl-N-dimethylethanolamine N-methyltransferase
R01321  CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
R01468  ATP:ethanolamine O-phosphotransferase
R01470  sn-glycero-3-phosphoethanolamine glycerophosphohydrolase
R01797  CDP-diacylglycerol phosphatidylhydrolase
R01799  CTP:phosphatidate cytidyltransferase
R01800  CDP-diacylglycerol:L-serine 3-phosphatidyltransferase
R01801  CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase
R01802  CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
R01890  CTP:choline-phosphate cytidylyltransferase
R02027  phosphatidylglycerol cholinephosphohydrolase
R02029  phosphatidylglycerophosphate phosphohydrolase
R02030  CDP-diacylglycerol:phosphatidylglycerol 3-phosphatidyltransferase
R02037  S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase
R02038  CTP:ethanolamine-phosphate cytidylyltransferase
R02051  phosphatidylethanolamine phosphatidohydrolase
R02052  phosphatidylethanolamine ethanolaminephosphohydrolase
R02053  phosphatidylethanolamine 2-acylhydrolase
R02054  phosphatidylethanolamine 1-acylhydrolase
R02055  phsophatidyl-L-serine carboxy-lyase
R02056  S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase
R02057  CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
R02114  phosphatidylcholine:sterol O-acyltransferase
R02239  1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase
R02240  ATP:1,2-diacylglycerol 3-phosphotransferase
R02241  acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
R02242  acyl-CoA:2-acyl-sn-glycerol-3-phosphate O-acyltransferase
R02563  CDPethanolamine:L-serine ethanolaminephosphotransferase
R02746  1-acyl-sn-glycero-3-phosphocholine acylhydrolase
R02747  2-acyl-sn-glycero-3-phosphocholine acylhydrolase
R02756   
R02817  serine-phosphoethanolamine ethanolaminephosphohydrolase
R03360  1-phosphatidyl-D-myo-inositol 2-acylhydrolase
R03416  1-acyl-sn-glycero-3-phosphoethanolamine aldehydohydrolase
R03417  L-2-lysophosphatidylethanolamine aldehydohydrolase
R03424  S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
R04034  3-sn-phosphatidyl-L-serine sn-1 acylhydrolase
R04158  geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase
R04480  acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase
R04520  geranylgeranyl-diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase
R04864  2-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase
R05381  diethanolamine ethanolamine-lyase (acetaldehyde-forming)
R05382  triethanolamine diethanolamine-lyase (acetaldehyde-forming)
R05679  sn-glycerol-1-phosphate:NAD 2-oxidoreductase
R05680  sn-glycerol-1-phosphate:NADP 2-oxidoreductase
R05794  CDP-diacylglycerol:choline O-phosphatidyltransferase
R06868  S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase
R06869  S-adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase
R06870  phosphoethanolamine phosphohydrolase
R06871  phosphocholine phosphohydrolase
R06872  acyl-CoA:sn-glycerol-3-phosphate 2-O-acyltransferase
R07376  L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
R07377   
R07390   
R08966  CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol-1-phosphate cytidylyltransferase
R09034  acyl-CoA:1-acyl-sn-glycero-3-phosphoinositol O-acyltransferase
R09035  acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase
R09036  acyl-CoA:1-acyl-sn-glycero-3-phosphoglycerol O-acyltransferase
R09037   
R09038  cardiolipin acylhydrolase
R09072  S-adenosyl-L-methionine:1,2-diacyl-sn-glycerol 3-amino-3-carboxypropyltransferase
R09073  S-adenosylmethionine:diacylglycerylhomoserine N-methyltransferase (diacylglyceryl-N,N,N-trimethylhomoserine-forming)
R09944  CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase
R10255  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-(O-geranylgeranyl)-sn-glycerol phosphotransferase
R10325  2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:NAD+ oxidoreductase
R10326  2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate:NADP+ oxidoreductase
R10331  2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
R11062  phosphatidylethanolamine:phosphatidylglycerol 3-phosphatidyltransferase
R12241  acyl phosphoate:sn-glycerol 3-phosphate acyltransferase
R12699   
R12700   
R12701   
R12757   
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00260  Glycine, serine and threonine metabolism
rn00561  Glycerolipid metabolism
rn00562  Inositol phosphate metabolism
rn00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
rn00565  Ether lipid metabolism
rn00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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