KEGG   PATHWAY: ko00564Help
Entry
ko00564                     Pathway                                

Name
Glycerophospholipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ko00564  Glycerophospholipid metabolism
ko00564

Ortholog table
Module
M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ko00564]
M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ko00564]
M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ko00564]
M00093  Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ko00564]
Disease
H00158  Lecithin:cholesterol acyltransferase deficiency
H00207  Rhizomelic chondrodysplasia punctata
H00654  Barth syndrome
H00770  Congenital myasthenic syndrome
H01117  Chronic recurrent multifocal osteomyelitis
H01290  Acute recurrent myoglobinuria
H01821  Spondylometaphyseal dysplasia with cone-rod dystrophy
H01832  Lenz-Majewski syndrome
H01898  PNPLA6-related disorders
H02137  Laurence-Moon syndrome
H02140  Boucher-Neuhauser syndrome
Other DBs
GO: 0006650 0046474 0046475
Orthology
K00006  glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
K00057  glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
K00105  alpha-glycerophosphate oxidase [EC:1.1.3.21]
K00111  glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]
K00112  glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3]
K00113  glycerol-3-phosphate dehydrogenase subunit C
K00629  glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15]
K13506  glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]
K13507  glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42]
K00630  glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K13508  glycerol-3-phosphate acyltransferase [EC:2.3.1.15 2.3.1.198]
K00631  glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
K08591  acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
K00655  1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
K13509  lysophosphatidate acyltransferase [EC:2.3.1.51]
K13523  lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
K19007  lysophosphatidiate acyltransferase [EC:2.3.1.51]
K13513  lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]
K13517  lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
K13519  lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-]
K14674  TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]
K22831  1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51]
K00649  glyceronephosphate O-acyltransferase [EC:2.3.1.42]
K06123  1-acylglycerone phosphate reductase [EC:1.1.1.101]
K00980  glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]
K01517  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [EC:3.6.1.13 3.6.1.16 3.6.1.53]
K01080  phosphatidate phosphatase [EC:3.1.3.4]
K15728  phosphatidate phosphatase LPIN [EC:3.1.3.4]
K18693  diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.1.3.81 3.1.3.4]
K00901  diacylglycerol kinase (ATP) [EC:2.7.1.107]
K07029  diacylglycerol kinase (ATP) [EC:2.7.1.107]
K16368  diacylglycerol kinase (CTP) [EC:2.7.1.174]
K00994  diacylglycerol cholinephosphotransferase [EC:2.7.8.2]
K13644  choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2]
K01114  phospholipase C [EC:3.1.4.3]
K16619  phospholipase C / alpha-toxin [EC:3.1.4.3]
K18694  phosphatidylglycerol phospholipase C [EC:3.1.4.-]
K01115  phospholipase D1/2 [EC:3.1.4.4]
K16860  phospholipase D3/4 [EC:3.1.4.4]
K17717  phospholipase D [EC:3.1.4.4]
K00650  lecithin-cholesterol acyltransferase [EC:2.3.1.43]
K01047  secretory phospholipase A2 [EC:3.1.1.4]
K16342  cytosolic phospholipase A2 [EC:3.1.1.4]
K16343  calcium-independent phospholipase A2 [EC:3.1.1.4]
K14621  phospholipase B1, membrane-associated [EC:3.1.1.4 3.1.1.5]
K16817  HRAS-like suppressor 3 [EC:3.1.1.32 3.1.1.4]
K01058  phospholipase A1/A2 [EC:3.1.1.32 3.1.1.4]
K13510  lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]
K13512  lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]
K13515  lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]
K16818  phospholipase A1 [EC:3.1.1.32]
K22389  phospholipase A1 [EC:3.1.1.32]
K06128  lysophospholipase I [EC:3.1.1.5]
K06129  lysophospholipase III [EC:3.1.1.5]
K06130  lysophospholipase II [EC:3.1.1.5]
K13333  lysophospholipase [EC:3.1.1.5]
K01048  lysophospholipase [EC:3.1.1.5]
K14676  lysophospholipid hydrolase [EC:3.1.1.5]
K18695  glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]
K18696  glycerophosphodiester phosphodiesterase [EC:3.1.4.46]
K01126  glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
K00623  choline O-acetyltransferase [EC:2.3.1.6]
K01049  acetylcholinesterase [EC:3.1.1.7]
K00866  choline kinase [EC:2.7.1.32]
K14156  choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]
K06124  phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75]
K00968  choline-phosphate cytidylyltransferase [EC:2.7.7.15]
K00993  ethanolaminephosphotransferase [EC:2.7.8.1]
K05939  acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
K00894  ethanolamine kinase [EC:2.7.1.82]
K00967  ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14]
K05929  phosphoethanolamine N-methyltransferase [EC:2.1.1.103]
K04019  ethanolamine utilization protein EutA
K03735  ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]
K03736  ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]
K14286  ethanolamine-phosphate phospho-lyase [EC:4.2.3.2]
K00551  phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71]
K16369  phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17]
K00550  phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71]
K00570  phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71]
K01521  CDP-diacylglycerol pyrophosphatase [EC:3.6.1.26]
K00981  phosphatidate cytidylyltransferase [EC:2.7.7.41]
K01004  phosphatidylcholine synthase [EC:2.7.8.24]
K00998  CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
K17103  CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
K13618  phosphatidylserine sn-1 acylhydrolase [EC:3.1.1.111]
K08729  phosphatidylserine synthase 1 [EC:2.7.8.-]
K08730  phosphatidylserine synthase 2 [EC:2.7.8.29]
K01613  phosphatidylserine decarboxylase [EC:4.1.1.65]
K00995  CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
K01094  phosphatidylglycerophosphatase GEP4 [EC:3.1.3.27]
K01095  phosphatidylglycerophosphatase A [EC:3.1.3.27]
K01096  phosphatidylglycerophosphatase B [EC:3.1.3.27 3.1.3.81 3.1.3.4 3.6.1.27]
K18697  phosphatidylglycerophosphatase C [EC:3.1.3.27]
K06131  cardiolipin synthase A/B [EC:2.7.8.-]
K06132  cardiolipin synthase C [EC:2.7.8.-]
K08744  cardiolipin synthase (CMP-forming) [EC:2.7.8.41]
K13511  monolysocardiolipin acyltransferase [EC:2.3.1.-]
K13535  cardiolipin-specific phospholipase [EC:3.1.1.-]
K13514  lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]
K00999  CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K13516  lysophospholipid acyltransferase 7 [EC:2.3.1.-]
K13621  betaine lipid synthase
K13622  S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
K13623  S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase
K00096  glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261]
K17104  phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41]
K17105  geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42]
K19664  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67]
K19665  archaetidylserine synthase [EC:2.7.8.38]
K17830  digeranylgeranylglycerophospholipid reductase [EC:1.3.1.101 1.3.7.11]
Compound
C00040  Acyl-CoA
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00260  Glycine, serine and threonine metabolism
ko00561  Glycerolipid metabolism
ko00562  Inositol phosphate metabolism
ko00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
ko00565  Ether lipid metabolism
ko00620  Pyruvate metabolism
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