Entry Name Glycerophospholipid metabolism
Class Metabolism; Lipid metabolismBRITE hierarchy
Pathway map ko00564 Glycerophospholipid metabolism
Module M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:ko00564 ]
M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:ko00564 ]
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:ko00564 ]
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:ko00564 ]
Other DBs Orthology K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8 ]
K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94 ]
K00096 araM, egsA; glycerol-1-phosphate dehydrogenase [NAD(P)+] [EC:1.1.1.261 ]
K00111 glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3 ]
K00112 glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3 ]
K00113 glpC; glycerol-3-phosphate dehydrogenase subunit C
K00550 PLMT; phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.71 ]
K00551 PEMT; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71 ]
K00570 pmtA; phosphatidylethanolamine/phosphatidyl-N-methylethanolamine N-methyltransferase [EC:2.1.1.17 2.1.1.71 ]
K00629 GPAT1_2; glycerol-3-phosphate O-acyltransferase 1/2 [EC:2.3.1.15 ]
K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51 ]
K00967 PCYT2; ethanolamine-phosphate cytidylyltransferase [EC:2.7.7.14 ]
K00981 E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41 ]
K00994 CHPT1, CPT1; diacylglycerol cholinephosphotransferase [EC:2.7.8.2 ]
K00995 PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5 ]
K00998 pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8 ]
K00999 CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11 ]
K01126 E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46 ]
K03735 eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7 ]
K03736 eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7 ]
K04019 eutA; ethanolamine utilization protein EutA
K05929 E2.1.1.103, NMT; phosphoethanolamine N-methyltransferase [EC:2.1.1.103 ]
K05939 aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20 ]
K06124 PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [EC:3.1.3.75 ]
K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]
K06132 clsC; cardiolipin synthase C [EC:2.7.8.-]
K07094 pcrB; heptaprenylglyceryl phosphate synthase [EC:2.5.1.-]
K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275 ]
K08729 PTDSS1; phosphatidylserine synthase 1 [EC:2.7.8.-]
K13506 GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15 ]
K13507 GAT; glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase [EC:2.3.1.15 2.3.1.42 ]
K13511 TAZ; monolysocardiolipin acyltransferase [EC:2.3.1.-]
K13512 LPCAT4, AGPAT7; lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]
K13513 LCLAT1, AGPAT8; lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51 ]
K13514 LPGAT1; lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]
K13515 LPCAT3, MBOAT5; lysophospholipid acyltransferase 5 [EC:2.3.1.23 2.3.1.-]
K13516 MBOAT7; lysophospholipid acyltransferase 7 [EC:2.3.1.-]
K13517 MBOAT1_2; lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-]
K13523 AGPAT3_4; lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase [EC:2.3.1.51 2.3.1.-]
K13535 CLD1; cardiolipin-specific phospholipase [EC:3.1.1.-]
K13621 BTA1; betaine lipid synthase
K13622 btaA; S-adenosylmethionine-diacylglycerol 3-amino-3-carboxypropyl transferase
K13623 btaB; S-adenosylmethionine-diacylgycerolhomoserine-N-methlytransferase
K14286 AGXT2L1, ETNPPL; ethanolamine-phosphate phospho-lyase [EC:4.2.3.2 ]
K16343 PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4 ]
K16369 CHO2; phosphatidylethanolamine N-methyltransferase [EC:2.1.1.17 ]
K17103 CHO1, pssA; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8 ]
K17104 E2.5.1.41; phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41 ]
K17105 E2.5.1.42; geranylgeranylglycerol-phosphate geranylgeranyltransferase [EC:2.5.1.42 ]
K18693 DPP1, DPPL, PLPP4_5; diacylglycerol diphosphate phosphatase / phosphatidate phosphatase [EC:3.6.1.75 3.1.3.4 ]
K18694 PGC1; phosphatidylglycerol phospholipase C [EC:3.1.4.-]
K18695 GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2 ]
K19664 carS; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase [EC:2.7.7.67 ]
K22831 LOA1; 1-acylglycerol-3-phosphate O-acyltransferase [EC:2.3.1.51 ]
K24872 yvoF; heptaprenylglycerol acetyltransferase
K25193 SDC; serine decarboxylase
Compound C00093 sn-Glycerol 3-phosphate
C00350 Phosphatidylethanolamine
C00623 sn-Glycerol 1-phosphate
C00670 sn-Glycero-3-phosphocholine
C00681 1-Acyl-sn-glycerol 3-phosphate
C01194 1-Phosphatidyl-D-myo-inositol
C01210 N-Methylethanolamine phosphate
C01233 sn-Glycero-3-phosphoethanolamine
C01241 Phosphatidyl-N-methylethanolamine
C03372 Acylglycerone phosphate
C03819 1-Acylglycerophosphoinositol
C03872 L-Serine-phosphoethanolamine
C03892 Phosphatidylglycerophosphate
C03974 2-Acyl-sn-glycerol 3-phosphate
C04230 1-Acyl-sn-glycero-3-phosphocholine
C04233 2-Acyl-sn-glycero-3-phosphocholine
C04308 Phosphatidyl-N-dimethylethanolamine
C04438 1-Acyl-sn-glycero-3-phosphoethanolamine
C04590 3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638 2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973 2-Acyl-sn-glycero-3-phosphoethanolamine
C05974 2-Acyl-sn-glycero-3-phosphoserine
C05976 Aminoacyl-phosphatidylglycerol
C13482 Phosphodimethylethanolamine
C18059 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125 1-Acyl-sn-glycero-3-phosphoserine
C18126 1-Acyl-sn-glycero-3-phosphoglycerol
C18168 Diacylglycerylhomoserine
C18169 Diacylglyceryl-N,N,N-trimethylhomoserine
C20466 2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518 2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340 Heptaprenylglyceryl phosphate
C22342 Diacetylheptaprenylglycerol
Reference Authors Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
Title The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
Journal Reference Authors Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
Title Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
Journal Reference Authors Athenstaedt K, Daum G.
Title Phosphatidic acid, a key intermediate in lipid metabolism.
Journal Reference Authors Shields DJ, Lehner R, Agellon LB, Vance DE.
Title Membrane topography of human phosphatidylethanolamine N-methyltransferase.
Journal Reference Authors Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
Title Pathways for phosphatidylcholine biosynthesis in bacteria.
Journal Reference Authors Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
Title Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
Journal Reference Authors Hsu L, Jackowski S, Rock CO
Title Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
Journal J Biol Chem 266:13783-8 (1991)
Reference Authors Stone SJ, Vance JE.
Title Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00260 Glycine, serine and threonine metabolism
ko00562 Inositol phosphate metabolism
ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
