KEGG   PATHWAY: rro04980
Entry
rro04980                    Pathway                                
Name
Cobalamin transport and metabolism - Rhinopithecus roxellana (golden snub-nosed monkey)
Class
Organismal Systems; Digestive system
Pathway map
rro04980  Cobalamin transport and metabolism
rro04980

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104655617  THAP11; THAP domain-containing protein 11 [KO:K23211]
104658694  MMADHC; LOW QUALITY PROTEIN: methylmalonic aciduria and homocystinuria type D protein, mitochondrial [KO:K26006]
104660825  MMAA; methylmalonic aciduria type A protein, mitochondrial isoform X1 [KO:K07588] [EC:3.6.5.-]
104661167  HCFC1; host cell factor 1 isoform X3 [KO:K14966]
104662136  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
104662137  MMACHC; methylmalonic aciduria and homocystinuria type C protein [KO:K14618] [EC:1.16.1.6 2.5.1.151]
104668181  TCN2; transcobalamin-2 isoform X1 [KO:K14619]
104668865  LMBRD1; probable lysosomal cobalamin transporter isoform X1 [KO:K14617]
104671498  MMUT; methylmalonyl-CoA mutase, mitochondrial isoform X1 [KO:K01847] [EC:5.4.99.2]
104674086  MTRR; methionine synthase reductase isoform X1 [KO:K00597] [EC:1.16.1.8]
104675007  MMAB; corrinoid adenosyltransferase isoform X1 [KO:K00798] [EC:2.5.1.17]
104677566  ABCD4; ATP-binding cassette sub-family D member 4 isoform X1 [KO:K05678] [EC:7.6.2.8]
104679188  MTR; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
104679304  ZNF143; zinc finger protein 143 isoform X4 [KO:K20828]
104679429  TCN1; transcobalamin-1 isoform X1 [KO:K25741]
104679430  CBLIF; cobalamin binding intrinsic factor isoform X1 [KO:K14615]
104682264  CD320; CD320 antigen [KO:K06734]
104682853  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
rro00270  Cysteine and methionine metabolism
rro00280  Valine, leucine and isoleucine degradation
rro00670  One carbon pool by folate
rro04144  Endocytosis
rro04977  Vitamin digestion and absorption
KO pathway
ko04980   

DBGET integrated database retrieval system