KEGG   PATHWAY: rro04144
Entry
rro04144                    Pathway                                
Name
Endocytosis - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
rro04144  Endocytosis
rro04144

Other DBs
GO: 0006897
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653559  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104653681  [KO:K12491]
104654090  SH3GLB1; endophilin-B1 [KO:K11248]
104654391  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104654786  IST1; IST1 homolog isoform X1 [KO:K19476]
104654893  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
104654960  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X3 [KO:K12182]
104655006  CHMP6; LOW QUALITY PROTEIN: charged multivesicular body protein 6 [KO:K12195]
104655082  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
104655110  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
104655224  RAB7A; ras-related protein Rab-7a [KO:K07897]
104655303  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
104655327  STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705]
104655394  SNX4; sorting nexin-4 [KO:K17919]
104655427  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
104655533  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
104655625  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
104655840  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104655857  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
104655887  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
104655918  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
104655935  SPG21; maspardin [KO:K19367]
104656092  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
104656130  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
104656189  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
104656209  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
104656515  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2 [KO:K18443]
104656520  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
104656669  CLTCL1; clathrin heavy chain 2 isoform X2 [KO:K04646]
104656761  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
104656780  SNX12; sorting nexin-12 [KO:K17918]
104656782  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
104656905  USP8; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
104657007  ACAP2; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
104657236  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
104657263  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
104657765  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
104657832  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
104658117  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
104658364  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104658412  WIPF1; WAS/WASL-interacting protein family member 1 isoform X5 [KO:K19475]
104658667  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104658857  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
104658923  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
104659427  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
104659668  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
104659927  EHD3; EH domain-containing protein 3 [KO:K12476]
104660011  [KO:K05050]
104660012  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
104660013  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104660184  ARF4; ADP-ribosylation factor 4 [KO:K07939]
104660275  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
104660522  SH3GLB2; endophilin-B2 isoform X2 [KO:K21269]
104660711  EPN2; epsin-2 isoform X1 [KO:K12471]
104660736  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
104660928  SNX2; sorting nexin-2 [KO:K17917]
104660972  MVB12A; multivesicular body subunit 12A [KO:K12186]
104660998  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
104661005  RAB8A; ras-related protein Rab-8A [KO:K07901]
104661201  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
104661357  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
104661406  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
104661424  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
104661492  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X2 [KO:K12495]
104661631  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
104661905  [KO:K06751]
104661959  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
104662064  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
104662378  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
104662435  BIN1; myc box-dependent-interacting protein 1 isoform X2 [KO:K12562]
104662462  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
104662567  RAB11A; ras-related protein Rab-11A [KO:K07904]
104662580  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
104662618  [KO:K18462]
104662690  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
104662804  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
104662844  EHD1; EH domain-containing protein 1 [KO:K12483]
104662913  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
104662926  CLTC; clathrin heavy chain 1 [KO:K04646]
104663087  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
104663095  ARRB2; beta-arrestin-2 isoform X4 [KO:K04439]
104663132  AMPH; amphiphysin isoform X1 [KO:K12562]
104663221  CDC42; cell division control protein 42 homolog [KO:K04393]
104663230  [KO:K10364]
104663265  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5 [KO:K12491]
104663342  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
104663373  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
104663789  RAB22A; ras-related protein Rab-22A [KO:K07891]
104663844  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
104663985  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
104664260  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
104664355  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
104664378  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
104664389  MVB12B; multivesicular body subunit 12B isoform X2 [KO:K12186]
104664523  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
104664634  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
104664749  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
104664810  SNX32; sorting nexin-32 [KO:K17920]
104664846  IL2RA; interleukin-2 receptor subunit alpha isoform X4 [KO:K05068]
104664905  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
104665104  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
104665147  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
104665153  FOLR2; folate receptor beta isoform X1 [KO:K13649]
104665154  FOLR1; folate receptor alpha [KO:K13649]
104665155  [KO:K13649]
104665419  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
104665440  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
104665706  RAB5A; ras-related protein Rab-5A [KO:K07887]
104665747  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
104665821  CYTH3; cytohesin-3 [KO:K18441]
104665858  DNM1; dynamin-1 isoform X6 [KO:K01528] [EC:3.6.5.5]
104665869  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
104665992  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
104666010  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104666183  [KO:K06751]
104666311  VPS37B; vacuolar protein sorting-associated protein 37B isoform X2 [KO:K12185]
104666353  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
104666428  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
104666568  CYTH2; cytohesin-2 [KO:K18441]
104666636  CHMP3; charged multivesicular body protein 3 [KO:K12193]
104666805  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104666912  EHD4; EH domain-containing protein 4 [KO:K12477]
104666985  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
104667161  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
104667212  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
104667288  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
104667372  RHOA; transforming protein RhoA [KO:K04513]
104667478  CAV3; caveolin-3 [KO:K12959]
104667505  CLTA; clathrin light chain A isoform X1 [KO:K04644]
104667653  TSG101; LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein [KO:K12183]
104667836  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
104668078  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X3 [KO:K09526]
104668193  [KO:K06751]
104668401  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
104668434  [KO:K06751]
104668535  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
104668539  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
104668736  SMAP1; stromal membrane-associated protein 1 isoform X2 [KO:K12486]
104668781  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104668813  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
104668863  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
104669133  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
104669223  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
104669802  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
104669863  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
104670209  [KO:K06751]
104670239  RAB31; ras-related protein Rab-31 [KO:K07891]
104670244  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
104670461  DNM2; dynamin-2 isoform X1 [KO:K23484]
104670517  LDLR; low-density lipoprotein receptor [KO:K12473]
104670689  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
104671071  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
104671216  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
104671248  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
104671328  CCR5; C-C chemokine receptor type 5 [KO:K04180]
104671367  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
104671668  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
104671686  RUFY2; RUN and FYVE domain-containing protein 2 isoform X2 [KO:K12482]
104671747  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
104671949  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
104671954  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
104672036  ARF1; ADP-ribosylation factor 1 [KO:K07937]
104672074  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
104672078  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
104672079  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104672234  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
104672275  [KO:K12495]
104672293  WASHC1; WASH complex subunit 1 isoform X3 [KO:K18461]
104672803  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
104673193  [KO:K06751]
104673218  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
104673380  EHD2; EH domain-containing protein 2 [KO:K12469]
104673398  AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
104673466  CBLC; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
104673687  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
104673699  RAB5B; ras-related protein Rab-5B [KO:K07888]
104674059  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
104674205  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
104674278  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
104674409  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
104674418  ARF5; ADP-ribosylation factor 5 [KO:K07940]
104674702  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
104674706  [KO:K06751]
104674796  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104674872  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
104675228  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
104675410  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
104675498  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
104675847  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104676209  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
104676388  TFRC; transferrin receptor protein 1 [KO:K06503]
104676453  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
104676609  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
104676636  RBSN; rabenosyn-5 [KO:K12481]
104676771  [KO:K06751]
104676774  [KO:K06751]
104676845  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
104676956  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
104677026  CYTH1; cytohesin-1 isoform X3 [KO:K18441]
104677089  [KO:K06751]
104677192  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
104677469  SNX3; sorting nexin-3 [KO:K17918]
104677664  CHMP2B; charged multivesicular body protein 2b isoform X2 [KO:K12192]
104677887  RAB10; ras-related protein Rab-10 [KO:K07903]
104677943  SPART; spartin [KO:K19366]
104678056  [KO:K10054] [EC:2.3.2.-]
104678084  [KO:K06751]
104678130  [KO:K03283]
104678248  [KO:K06751]
104678518  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
104678543  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X3 [KO:K18442]
104678626  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
104678722  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
104678934  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
104678955  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
104679398  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
104679581  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
104679653  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
104679731  ARF3; ADP-ribosylation factor 3 [KO:K07938]
104679828  CAPZB; F-actin-capping protein subunit beta isoform X2 [KO:K10365]
104679985  CHMP5; charged multivesicular body protein 5 [KO:K12198]
104680112  VPS25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189]
104680178  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
104680280  EPN3; epsin-3 [KO:K12471]
104680360  RAB5C; ras-related protein Rab-5C [KO:K07889]
104680432  CLTB; clathrin light chain B isoform X2 [KO:K04645]
104680447  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
104680460  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
104680506  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
104680729  [KO:K12491]
104680952  EPN1; epsin-1 isoform X1 [KO:K12471]
104681048  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
104681089  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
104681367  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
104681751  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
104681826  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
104682246  VPS4B; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
104682269  RAB11B; ras-related protein Rab-11B [KO:K07905]
104682303  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
104682323  [KO:K10364]
104682357  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
104682395  [KO:K07937]
104682409  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
104682498  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104682503  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
104682632  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
104682636  CAV1; caveolin-1 isoform X1 [KO:K06278]
104682637  CAV2; caveolin-2 isoform X1 [KO:K12958]
104682753  ARF6; ADP-ribosylation factor 6 [KO:K07941]
104682804  ZFYVE27; protrudin isoform X1 [KO:K19368]
115891998  [KO:K10054] [EC:2.3.2.-]
115892023  [KO:K03283]
115895854  [KO:K05704] [EC:2.7.10.2]
115897009  [KO:K06751]
115897517  [KO:K10054] [EC:2.3.2.-]
115897528  [KO:K10054] [EC:2.3.2.-]
115899956  [KO:K12495]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
rro04060  Cytokine-cytokine receptor interaction
rro04070  Phosphatidylinositol signaling system
rro04130  SNARE interactions in vesicular transport
rro04142  Lysosome
rro04350  TGF-beta signaling pathway
KO pathway
ko04144   

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