KEGG   PATHWAY: sauq00260
Entry
sauq00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Staphylococcus aureus subsp. aureus ST228/16035 (MRSA)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sauq00260  Glycine, serine and threonine metabolism
sauq00260

Module
sauq_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sauq00260]
sauq_M00555  Betaine biosynthesis, choline => betaine [PATH:sauq00260]
sauq_M00621  Glycine cleavage system [PATH:sauq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Staphylococcus aureus subsp. aureus ST228/16035 (MRSA) [GN:sauq]
Gene
SAI4T8_1010060  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
SAI4T8_1009530  Aspartokinase [KO:K00928] [EC:2.7.2.4]
SAI4T8_1010070  asd; Aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SAI4T8_1009540  dhoM; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SAI4T8_1009560  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
SAI4T8_1009550  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
SAI4T8_1009440  gLY1; Aromatic amino acid beta-eliminating lyase/threonine aldolase [KO:K01620] [EC:4.1.2.48]
SAI4T8_1015570  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAI4T8_1018060  glxK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAI4T8_1005760  Similar to glycerate kinase [KO:K00865] [EC:2.7.1.165]
SAI4T8_1002850  Putative phosphoglycerate mutase Gpm3p [KO:K01834] [EC:5.4.2.11]
SAI4T8_1017920  gpm; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
SAI4T8_1006090  pgm; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
SAI4T8_1012620  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
SAI4T8_1004210  Pyridoxal phosphate-dependent acyltransferase,putative [KO:K00639] [EC:2.3.1.29]
SAI4T8_1011160  gcvPA; Probable glycine dehydrogenase [decarboxylating] subunit 1 [KO:K00282] [EC:1.4.4.2]
SAI4T8_1011150  gcvPB; Probable glycine dehydrogenase [decarboxylating] subunit 2 [KO:K00283] [EC:1.4.4.2]
SAI4T8_1011170  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
SAI4T8_1007790  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAI4T8_1011050  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAI4T8_1019510  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SAI4T8_1019520  gbsA; Glycine betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAI4T8_1003360  yrhB; Cystathionine gamma-synthase homolog [KO:K17217] [EC:4.4.1.1 4.4.1.2]
SAI4T8_1018860  Putative L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SAI4T8_1018870  Putative beta-subunit of L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
SAI4T8_1010390  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAI4T8_1015160  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAI4T8_1009880  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
SAI4T8_1009870  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sauq00010  Glycolysis / Gluconeogenesis
sauq00020  Citrate cycle (TCA cycle)
sauq00230  Purine metabolism
sauq00250  Alanine, aspartate and glutamate metabolism
sauq00270  Cysteine and methionine metabolism
sauq00290  Valine, leucine and isoleucine biosynthesis
sauq00300  Lysine biosynthesis
sauq00330  Arginine and proline metabolism
sauq00460  Cyanoamino acid metabolism
sauq00470  D-Amino acid metabolism
sauq00564  Glycerophospholipid metabolism
sauq00620  Pyruvate metabolism
sauq00630  Glyoxylate and dicarboxylate metabolism
sauq00640  Propanoate metabolism
sauq00680  Methane metabolism
sauq00860  Porphyrin metabolism
sauq00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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