KEGG   PATHWAY: seb00053
Entry
seb00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
Class
Metabolism; Carbohydrate metabolism
Pathway map
seb00053  Ascorbate and aldarate metabolism
seb00053

Module
seb_M00550  Ascorbate degradation, ascorbate => D-xylulose-5P [PATH:seb00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Salmonella enterica subsp. enterica serovar Typhimurium ST4/74 [GN:seb]
Gene
STM474_0104  araD; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
STM474_0908  ulaA; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM474_0909  [KO:K02822] [EC:2.7.1.194]
STM474_2165  udg; UDP-glucose/GDP-mannose dehydrogenase [KO:K00012] [EC:1.1.1.22]
STM474_2439  ulaA; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM474_2440  [KO:K02822] [EC:2.7.1.194]
STM474_2441  [KO:K02821] [EC:2.7.1.194]
STM474_3105  gudD; d-glucarate dehydratase [KO:K01706] [EC:4.2.1.40]
STM474_3406  garL; alpha-dehydro-beta-deoxy-D-glucarate aldolase [KO:K01630] [EC:4.1.2.20]
STM474_3407  garD; galactarate dehydrogenase [KO:K01708] [EC:4.2.1.42]
STM474_3840  yiaK; 2,3-diketo-L-gulonate reductase [KO:K08092] [EC:1.1.1.130]
STM474_3846  lyxK; L-xylulose kinase [KO:K00880] [EC:2.7.1.53]
STM474_3847  sgbH; 3-keto-L-gulonate-6-phosphate decarboxylase [KO:K03078] [EC:4.1.1.85]
STM474_3848  sgbU; putative L-xylulose 5-phosphate 3-epimerase [KO:K03079] [EC:5.1.3.22]
STM474_3849  sgbE; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
STM474_3870  [KO:K20023] [EC:4.2.1.156 4.2.1.42]
STM474_4579  ulag; putative L-ascorbate-6-phosphate lactonase ulaG [KO:K03476] [EC:3.1.1.-]
STM474_4580  ulaA; ascorbate-specific PTS system enzyme IIC [KO:K03475]
STM474_4581  sgaB; L-ascorbate-specific enzyme IIB component of PTS [KO:K02822] [EC:2.7.1.194]
STM474_4582  ptxA; L-ascorbate-specific enzyme IIA component of PTS [KO:K02821] [EC:2.7.1.194]
STM474_4583  ulad; 3-keto-L-gulonate-6-phosphate decarboxylase ulaD [KO:K03078] [EC:4.1.1.85]
STM474_4584  sgaU; L-xylulose 5-phosphate 3-epimerase [KO:K03079] [EC:5.1.3.22]
STM474_4585  sgaE; L-ribulose-5-phosphate 4-epimerase [KO:K03077] [EC:5.1.3.4]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
seb00020  Citrate cycle (TCA cycle)
seb00040  Pentose and glucuronate interconversions
seb00051  Fructose and mannose metabolism
seb00520  Amino sugar and nucleotide sugar metabolism
seb00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   

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