Entry Name Peptidoglycan biosynthesis - Thiomonas arsenitoxydans
Description Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class Metabolism; Glycan biosynthesis and metabolismBRITE hierarchy
Pathway map Organism Thiomonas arsenitoxydans [GN:
thi ]
Gene THI_0399 mraY; Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP-MurNAc-pentapeptide phosphotransferase) [KO:K01000 ] [EC:2.7.8.13 ]
THI_0402 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) [KO:K02563 ] [EC:2.4.1.227 ]
THI_0403 murC; UDP-N-acetylmuramate--L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase) [KO:K01924 ] [EC:6.3.2.8 ]
THI_0404 ddlB; D-alanine--D-alanine ligase B (D-alanylalanine synthetase B) (D-Ala-D-Ala ligase B) [KO:K01921 ] [EC:6.3.2.4 ]
THI_0848 mrcA; Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (DD-transpeptidase)] [KO:K05366 ] [EC:2.4.99.28 3.4.16.4 ]
THI_1111 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) [KO:K00790 ] [EC:2.5.1.7 ]
THI_1667 murB; UDP-N-acetylenolpyruvoylglucosamine reductase (UDP-N-acetylmuramate dehydrogenase) [KO:K00075 ] [EC:1.3.1.98 ]
THI_2468 uppS; Undecaprenyl pyrophosphate synthetase (UPP synthetase) (Di-trans,poly-cis-decaprenylcistransferase) (Undecaprenyl diphosphate synthase) (UDS) [KO:K00806 ] [EC:2.5.1.31 ]
Compound C00043 UDP-N-acetyl-alpha-D-glucosamine
C00448 trans,trans-Farnesyl diphosphate
C00692 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C01212 UDP-N-acetylmuramoyl-L-alanine
C04574 di-trans,poly-cis-Undecaprenyl diphosphate
C04631 UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702 UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851 MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896 Crosslinked peptidoglycan
C05897 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556 di-trans,poly-cis-Undecaprenyl phosphate
C17558 di-trans,poly-cis-Undecaprenol
C22053 UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference Authors Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
Title The biosynthesis of peptidoglycan lipid-linked intermediates.
Journal Reference Authors Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
Title Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
Journal Reference Authors Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
Title Cytoplasmic steps of peptidoglycan biosynthesis.
Journal Reference Authors van Heijenoort J
Title Recent advances in the formation of the bacterial peptidoglycan monomer unit.
Journal Reference Authors van Heijenoort J
Title Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
Journal Related thi00520 Amino sugar and nucleotide sugar metabolism
thi00900 Terpenoid backbone biosynthesis
KO pathway
