KEGG   PATHWAY: uah00980
Entry
uah00980                    Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Ursus arctos (brown bear)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
uah00980  Metabolism of xenobiotics by cytochrome P450
uah00980

Organism
Ursus arctos (brown bear) [GN:uah]
Gene
113240972  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
113241453  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
113247073  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113247088  glutathione S-transferase theta-4-like isoform X5 [KO:K00799] [EC:2.5.1.18]
113247089  glutathione S-transferase theta-1-like isoform X2 [KO:K00799] [EC:2.5.1.18]
113257838  MGST1; microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
113244917  GSTM3; glutathione S-transferase Mu 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
113255690  MGST2; microsomal glutathione S-transferase 2 isoform X2 [KO:K00799] [EC:2.5.1.18]
113268693  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
113251904  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
113251905  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
113247021  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
113247025  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
113261183  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
113261185  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
113261186  GSTA1; glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
113261187  glutathione S-transferase A3-like isoform X2 [KO:K00799] [EC:2.5.1.18]
125282883  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
125282884  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
130543420  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
130543421  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
113244886  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125280892  glutathione S-transferase Mu 4 isoform X2 [KO:K00799] [EC:2.5.1.18]
113244018  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
113244019  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
113265493  GSTK1; glutathione S-transferase kappa 1 isoform X2 [KO:K13299] [EC:2.5.1.18]
113263135  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
113262914  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
113240971  cytochrome P450 1A2 isoform X2 [KO:K07409] [EC:1.14.14.1]
113243548  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
113243544  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
113243321  DHDH; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
113262645  HSD11B1; 11-beta-hydroxysteroid dehydrogenase 1 [KO:K15680] [EC:1.1.1.146]
113242856  HSD11B1L; hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform X2 [KO:K15680] [EC:1.1.1.146]
113260850  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
125281469  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
125281470  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
125281471  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542629  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
125281499  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542639  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542666  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542667  carbonyl reductase [NADPH] 1-like isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
125281462  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542962  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
130542966  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
113244485  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
113260550  carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
130542675  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
113250325  UDP-glucuronosyltransferase 1A1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
113262548  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
113262550  UDP-glucuronosyltransferase 2A2 isoform X2 [KO:K00699] [EC:2.4.1.17]
113262552  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
125283434  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
125280979  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283091  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283092  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283435  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125283436  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
125281344  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
130542426  UDP-glucuronosyltransferase 1A10-like [KO:K00699] [EC:2.4.1.17]
130542430  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
125283093  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
130543210  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
113268586  aflatoxin B1 aldehyde reductase member 2-like isoform X2 [KO:K15303]
113249594  aflatoxin B1 aldehyde reductase member 2-like [KO:K15303]
125283075  aflatoxin B1 aldehyde reductase member 4-like [KO:K15303]
113271268  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
113244008  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
113244012  ALDH3B2; aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
113263118  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
113263120  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
113263121  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
113263119  ADH6; alcohol dehydrogenase 6 isoform X2 [KO:K13952] [EC:1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
PMID:12487150
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
PMID:10725110
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
PMID:10570027
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
PMID:10490505
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
PMID:15319346
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
PMID:15987776
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
PMID:15298956
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   
LinkDB

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