KEGG   MODULE: ype_M00307
Entry
ype_M00307        Pathway   Module                                 
Name
Pyruvate oxidation, pyruvate => acetyl-CoA
Definition
((K00163,K00161+K00162)+K00627+K00382-K13997),(K00169+K00170+K00171+(K00172,K00189)),K03737,(K28726+K28727+K28729+K28728),K21682
Diagram
ype_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
ype_M00307

Class
Pathway modules; Carbohydrate metabolism; Central carbohydrate metabolism
Pathway
ype00010  Glycolysis / Gluconeogenesis
ype00020  Citrate cycle (TCA cycle)
ype00620  Pyruvate metabolism
ype00785  Lipoic acid metabolism
ype01200  Carbon metabolism
ype01210  2-Oxocarboxylic acid metabolism
ype01100  Metabolic pathways
Organism
Yersinia pestis CO92 (biovar Orientalis) [GN:ype]
Gene
YPO2334  nifJ; putative pyruvate-flavodoxin oxidoreductase [KO:K03737]
YPO3417  lpd; dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase complex [KO:K00382]
YPO3418  aceF; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex [KO:K00627]
YPO3419  aceE; pyruvate dehydrogenase E1 component [KO:K00163]
YPO3917  putative pyridine nucleotide-disulphide oxidoreductase [KO:K00382]
Reaction
R00209,R01196,R10866,R00210  
R00014  
R03270  
R02569  
R07618  
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C15972  Enzyme N6-(lipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
RModule
RM044  2-Oxocarboxylic acid conversion to its CoA derivative
Comment
The oxidative decarboxylation of pyruvate to acetyl-CoA is catalyzed by the pyruvate dehydrogenase complex as part of aerobic respiration or by pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1].
KO module
M00307
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