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ENTRY	nt06034
Name	Cholesterol biosynthesis
Category	Pathway view; Lipid/glycolipid metabolism
Pathway	hsa00900 Terpenoid backbone biosynthesis hsa00100 Steroid biosynthesis
Module	hsa_M00095 C5 isoprenoid biosynthesis, mevalonate pathway hsa_M00367 C10-C20 isoprenoid biosynthesis, non-plant eukaryotes hsa_M00101 Cholesterol biosynthesis, FPP => cholesterol hsa_M00103 Cholecalciferol biosynthesis
Display	drug-target relation   disease type

N01635    Acetyl-CoA − ACAT ⇉ HMGCS ⇉ HMGCR ⇉ MVK ⇉ PMVK ⇉ MVD ⇉ IDI ⇉ (FDPS,GGPS1) → Farnesyl-PP     MEVA/POROK3                 MVK*     POROK1                     PMVK*     POROK7                         MVD*     POROK9                                 FDPS*   N01624    Farnesyl-PP − FDFT1 ⇉ SQLE ⇉ LSS ⇉ CYP51A1 ⇉ (TM7SF2,LBR) ⇉ MSMO1 ⇉ NSDHL ⇉ HSD17B7 ⇉ DHCR24 ⇉ EBP ⇉ SC5D → 7-DHC − DHCR7 → Cholesterol     APMR4             LSS*     GRBGD                     LBR*     MCCPD                         MSMO1*     CHILD/CKS                             NSDHL*     Desmosterolosis                                     DHCR24*     CDPX2/MEND                                         EBP*     LATHOS                                             SC5D*     SLOS                                                     DHCR7*   N01626    7-DHC − CYP2R1 ⇉ CYP27B1 ⇉ Calcitriol     VDDR1B     CYP2R1*     VDDR1A         CYP27B1*

		Disease name	Disease category
MEVA/POROK3	H00206	Mevalonate kinase deficiency	Inherited metabolic disorder
	H01933	Porokeratosis	Congenital malformation
POROK1	H01933	Porokeratosis	Congenital malformation
POROK7	H01933	Porokeratosis	Congenital malformation
POROK9	H01933	Porokeratosis	Congenital malformation
APMR4	H02303	Alopecia-mental retardation syndrome	Congenital malformation
GRBGD	H00447	HEM skeletal dysplasia	Congenital malformation
MCCPD	H02132	Microcephaly syndrome	Congenital malformation
CHILD/CKS	H00496	Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)	Congenital malformation
	H01917	CK syndrome	Congenital malformation
Desmosterolosis	H00617	Desmosterolosis	Inherited metabolic disorder
CDPX2/MEND	H01194	X-linked chondrodysplasia punctata	Congenital malformation
	H02248	MEND syndrome	Congenital malformation
LATHOS	H01281	Lathosterolosis	Inherited metabolic disorder
SLOS	H00161	Smith-Lemli-Opitz syndrome	Inherited metabolic disorder
VDDR1B	H01143	Vitamin D-dependent rickets	Inherited metabolic disorder
VDDR1A	H01143	Vitamin D-dependent rickets	Inherited metabolic disorder