KEGG   Homo sapiens (human): 2224
Entry
2224              CDS       T01001                                 
Symbol
FDPS, FPPS, FPS, POROK9
Name
(RefSeq) farnesyl diphosphate synthase
  KO
K00787  farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
hsa05164  Influenza A
hsa05166  Human T-cell leukemia virus 1 infection
Module
hsa_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Network
nt06034  Cholesterol biosynthesis
  Element
N01635  Mevalonate pathway
Disease
H01933  Porokeratosis
Drug target
Alendronic acid (DG00783): D00939<JP/US> D07119
Ibandronic acid (DG00785): D04486<JP/US> D08056
Incadronic acid (DG01266): D07123 D08073
Minodronic acid hydrate: D09198<JP>
Pamidronic acid (DG00782): D00941<JP/US> D07281
Risedronic acid (DG00786): D00942<US> D03234<JP/US> D08484 D11570<US>
Zoledronic acid (DG00787): D01968<JP/US> D06378 D06379 D08689 D10515
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    2224 (FDPS)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    2224 (FDPS)
   05164 Influenza A
    2224 (FDPS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    2224 (FDPS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     2224 (FDPS)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     2224 (FDPS)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   2224 (FDPS)
SSDB
Motif
Pfam: polyprenyl_synt
Other DBs
NCBI-GeneID: 2224
NCBI-ProteinID: NP_001129293
OMIM: 134629
HGNC: 3631
Ensembl: ENSG00000160752
UniProt: P14324
Structure
LinkDB
Position
1:155308866..155320665
AA seq 419 aa
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
NT seq 1260 nt   +upstreamnt  +downstreamnt
atgcccctgtcccgctggttgagatctgtgggggtcttcctgctgccagccccctactgg
gcaccccgggagaggtggctgggttccctacggcggccctccctggtgcacgggtaccca
gtcctggcctggcacagtgcccgctgctggtgccaagcgtggacagaggaacctcgagcc
ctttgctcctccctcagaatgaacggagaccagaattcagatgtttatgcccaagaaaag
caggatttcgttcagcacttctcccagatcgttagggtgctgactgaggatgagatgggg
cacccagagataggagatgctattgcccggctcaaggaggtcctggagtacaatgccatt
ggaggcaagtataaccggggtttgacggtggtagtagcattccgggagctggtggagcca
aggaaacaggatgctgatagtctccagcgggcctggactgtgggctggtgtgtggaactg
ctgcaagctttcttcctggtggcagatgacatcatggattcatcccttacccgccgggga
cagatctgctggtatcagaagccgggcgtgggtttggatgccatcaatgatgctaacctc
ctggaagcatgtatctaccgcctgctgaagctctattgccgggagcagccctattacctg
aacctgatcgagctcttcctgcagagttcctatcagactgagattgggcagaccctggac
ctcctcacagccccccagggcaatgtggatcttgtcagattcactgaaaagaggtacaaa
tctattgtcaagtacaagacagctttctactccttctaccttcctatagctgcagccatg
tacatggcaggaattgatggcgagaaggagcacgccaatgccaagaagatcctgctggag
atgggggagttctttcagattcaggatgattaccttgacctctttggggaccccagtgtg
accggcaaaattggcactgacatccaggacaacaaatgcagctggctggtggttcagtgt
ctgcaacgggccactccagaacagtaccagatcctgaaggaaaattacgggcagaaggag
gctgagaaagtggcccgggtgaaggcgctatatgaggagctggatctgccagcagtgttc
ttgcaatatgaggaagacagttacagccacattatggctctcattgaacagtacgcagca
cccctgcccccagccgtctttctggggcttgcgcgcaaaatctacaagcggagaaagtga

KEGG   Homo sapiens (human): 9453
Entry
9453              CDS       T01001                                 
Symbol
GGPS1, GGPPS, GGPPS1, MDHLO, MUDHLOV
Name
(RefSeq) geranylgeranyl diphosphate synthase 1
  KO
K00804  geranylgeranyl diphosphate synthase, type III [EC:2.5.1.1 2.5.1.10 2.5.1.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Network
nt06034  Cholesterol biosynthesis
  Element
N01635  Mevalonate pathway
Disease
H02798  Muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    9453 (GGPS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    9453 (GGPS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     9453 (GGPS1)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     9453 (GGPS1)
    2.5.1.29  geranylgeranyl diphosphate synthase
     9453 (GGPS1)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   9453 (GGPS1)
SSDB
Motif
Pfam: polyprenyl_synt
Other DBs
NCBI-GeneID: 9453
NCBI-ProteinID: NP_001032354
OMIM: 606982
HGNC: 4249
Ensembl: ENSG00000152904
UniProt: O95749
Structure
LinkDB
Position
1:235327216..235344532
AA seq 300 aa
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
NT seq 903 nt   +upstreamnt  +downstreamnt
atggagaagactcaagaaacagtccaaagaattcttctagaaccctataaatacttactt
cagttaccaggtaaacaagtgagaaccaaactttcacaggcatttaatcattggctgaaa
gttccagaggacaagctacagattattattgaagtgacagaaatgttgcataatgccagt
ttactcatcgatgatattgaagacaactcaaaactccgacgtggctttccagtggcccac
agcatctatggaatcccatctgtcatcaattctgccaattacgtgtatttccttggcttg
gagaaagtcttaacccttgatcacccagatgcagtgaagctttttacccgccagcttttg
gaactccatcagggacaaggcctagatatttactggagggataattacacttgtcccact
gaagaagaatataaagctatggtgctgcagaaaacaggtggactgtttggattagcagta
ggtctcatgcagttgttctctgattacaaagaagatttaaaaccgctacttaatacactt
gggctctttttccaaattagggatgattatgctaatctacactccaaagaatatagtgaa
aacaaaagtttttgtgaagatctgacagagggaaagttctcatttcctactattcatgct
atttggtcaaggcctgaaagcacccaggtgcagaatatcttgcgccagagaacagaaaac
atagatataaaaaaatactgtgtacattatcttgaggatgtaggttcttttgaatacact
cgtaatacccttaaagagcttgaagctaaagcctataaacagattgatgcacgtggtggg
aaccctgagctagtagccttagtaaaacacttaagtaagatgttcaaagaagaaaatgaa
taa

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