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ENTRY	nt06034
Name	Cholesterol biosynthesis
Category	Pathway view; Lipid/glycolipid metabolism
Pathway	hsa00900 Terpenoid backbone biosynthesis hsa00100 Steroid biosynthesis
Module	hsa_M00095 C5 isoprenoid biosynthesis, mevalonate pathway hsa_M00367 C10-C20 isoprenoid biosynthesis, non-plant eukaryotes hsa_M00101 Cholesterol biosynthesis, FPP => cholesterol hsa_M00103 Cholecalciferol biosynthesis
Display	drug-target relation   disease type

N01635    Acetyl-CoA − ACAT ⇉ HMGCS ⇉ HMGCR ⇉ MVK ⇉ PMVK ⇉ MVD ⇉ IDI ⇉ (FDPS,GGPS1) → Farnesyl-PP     CMYO28         HMGCS1*     MEVA/POROK3                 MVK*     POROK1                     PMVK*     POROK7                         MVD*     POROK9                                 FDPS*   N01624    Farnesyl-PP − FDFT1 ⇉ SQLE ⇉ LSS ⇉ CYP51A1 ⇉ (TM7SF2,LBR) ⇉ MSMO1 ⇉ NSDHL ⇉ HSD17B7 ⇉ DHCR24 ⇉ EBP ⇉ SC5D → 7-DHC − DHCR7 → Cholesterol     SQSD     FDFT1*     APMR4             LSS*     GRBGD                     LBR*     MCCPD                         MSMO1*     CHILD/CKS                             NSDHL*     Desmosterolosis                                     DHCR24*     CDPX2/MEND                                         EBP*     LATHOS                                             SC5D*     SLOS                                                     DHCR7*   N01626    7-DHC − CYP2R1 ⇉ CYP27B1 ⇉ Calcitriol     VDDR1B     CYP2R1*     VDDR1A         CYP27B1*

		Disease name	Disease category
CMYO28	H01810	Congenital myopathy	Nervous system disease
MEVA/POROK3	H00206	Mevalonate kinase deficiency	Inherited metabolic disorder
	H01933	Porokeratosis	Congenital malformation
POROK1	H01933	Porokeratosis	Congenital malformation
POROK7	H01933	Porokeratosis	Congenital malformation
POROK9	H01933	Porokeratosis	Congenital malformation
SQSD	H03060	Squalene synthase deficiency	Inherited metabolic disorder
APMR4	H02303	Alopecia-mental retardation syndrome	Congenital malformation
GRBGD	H00447	HEM skeletal dysplasia	Congenital malformation
MCCPD	H02132	Microcephaly syndrome	Congenital malformation
CHILD/CKS	H00496	Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)	Congenital malformation
	H01917	CK syndrome	Congenital malformation
Desmosterolosis	H00617	Desmosterolosis	Inherited metabolic disorder
CDPX2/MEND	H01194	X-linked chondrodysplasia punctata	Congenital malformation
	H02248	MEND syndrome	Congenital malformation
LATHOS	H01281	Lathosterolosis	Inherited metabolic disorder
SLOS	H00161	Smith-Lemli-Opitz syndrome	Inherited metabolic disorder
VDDR1B	H01143	Vitamin D-dependent rickets	Inherited metabolic disorder
VDDR1A	H01143	Vitamin D-dependent rickets	Inherited metabolic disorder