KEGG    Network variation - Cholesterol biosynthesis
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ENTRYnt06034
NameCholesterol biosynthesis
CategoryPathway view; Lipid/glycolipid metabolism
Pathwayhsa00900 Terpenoid backbone biosynthesis
hsa00100 Steroid biosynthesis
Modulehsa_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
hsa_M00367 C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
hsa_M00101 Cholesterol biosynthesis, FPP => cholesterol
hsa_M00103 Cholecalciferol biosynthesis
Display drug-target relation   disease type
N01635    Acetyl-CoAACATHMGCSHMGCRMVKPMVKMVDIDI(FDPS,GGPS1)Farnesyl-PP
N90849    MEVA/POROK3         
    POROK1           PMVK*
    POROK7             MVD*
    POROK9                 FDPS*
 
N01624    Farnesyl-PPFDFT1SQLELSSCYP51A1(TM7SF2,LBR)MSMO1NSDHLHSD17B7DHCR24EBPSC5D7-DHCDHCR7Cholesterol
    APMR4       LSS*
    GRBGD           LBR*
    MCCPD             MSMO1*
    CHILD/CKS               NSDHL*
    Desmosterolosis                   DHCR24*
    CDPX2/MEND                     EBP*
    LATHOS                       SC5D*
    SLOS                           DHCR7*
 
N01626    7-DHCCYP2R1CYP27B1Calcitriol
    VDDR1B   CYP2R1*
    VDDR1A     CYP27B1*

Disease nameDisease category
MEVA/POROK3H00206Mevalonate kinase deficiencyInherited metabolic disorder
H01933PorokeratosisCongenital malformation
POROK1H01933PorokeratosisCongenital malformation
POROK7H01933PorokeratosisCongenital malformation
POROK9 H01933PorokeratosisCongenital malformation
APMR4H02303Alopecia-mental retardation syndromeCongenital malformation
GRBGDH00447HEM skeletal dysplasiaCongenital malformation
MCCPDH02132Microcephaly syndromeCongenital malformation
CHILD/CKSH00496Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)Congenital malformation
H01917CK syndromeCongenital malformation
DesmosterolosisH00617DesmosterolosisInherited metabolic disorder
CDPX2/MENDH01194X-linked chondrodysplasia punctataCongenital malformation
H02248MEND syndromeCongenital malformation
LATHOSH01281LathosterolosisInherited metabolic disorder
SLOSH00161Smith-Lemli-Opitz syndromeInherited metabolic disorder
VDDR1BH01143Vitamin D-dependent ricketsInherited metabolic disorder
VDDR1AH01143Vitamin D-dependent ricketsInherited metabolic disorder