KEGG    Network variation - TRH-TSH-TH signaling
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ENTRYnt06322
NameTRH-TSH-TH signaling
CategoryPathway view; Endocrine system
Pathwayhsa04918 Thyroid hormone synthesis
DiseaseH00250 Congenital nongoitrous hypothyroidism (CHNG)
H00251 Thyroid dyshormonogenesis
Display drug-target relation   disease type
N00918    TRH→TRHR→GNAQ/11→PLCB→(Ca2+,DAG)→PKC→TSHB
    CHNG   TRHR*
 
N00782    TSHB→TSHR→GNAS→ADCY→cAMP→PKA→(TTF1,TTF2,PAX8,CR..⇒TG
    CHNG TSHB*
    CHNG   TSHR*
    Congenital hyperthyroidism   TSHR*↗
    CHNG             PAX8*
 
N00793    TSHB→TSHR→GNAQ→PLCB→(Ca2+,DAG)→PKC→DUOX2→H2O2→TG
    Thyroid dyshormonogenesis             DUOX2*
N00795              DUOXA2→DUOX2→H2O2
    Thyroid dyshormonogenesis           DUOXA2*
 
N00786    Iodide(blood)−(SLC5A5,SLC26A4)→Iodide
    Thyroid dyshormonogenesis   SLC5A5*
    Thyroid dyshormonogenesis   SLC26A4*
 
   D3,D4
 |		   D3,D4
 |		  
N00803    TG+(Iodide+Tyr)−TPO→TG+(MIT,DIT)−TPO→TG+(T3,T4)
    Thyroid dyshormonogenesis TG*
N00789    Thyroid dyshormonogenesis TG+(Iodide+Tyr)−TPO*⌿TG+(MIT,DIT)−TPO*⌿TG+(T3,T4)
 
N00791    (MIT,DIT)−IYD→Iodide
    Thyroid dyshormonogenesis   IYD*
 
     D1,D2
 |		    
N00798    (SLC16A10,SLC16A2)→T3→(THRB,THRA)=RXR⇒(MYH6,ATP2A2)
    AHDS SLC16A2*
    CHNG     THRA*
    Thyroid hormone resistance syndrome     THRB*

Disease nameDisease category
CHNGH00250Congenital nongoitrous hypothyroidism (CHNG)Endocrine and metabolic disease
Congenital hyperthyroidismH01269Congenital hyperthyroidismEndocrine and metabolic disease
Thyroid dyshormonogenesisH00251Thyroid dyshormonogenesisEndocrine and metabolic disease
AHDSH00650Allan-Herndon-Dudley syndromeEndocrine and metabolic disease
Thyroid hormone resistance syndromeH00249Thyroid hormone resistance syndromeEndocrine and metabolic disease


Drug name
D1D01010Levothyroxine sodium (USP)
D2D01011Liothyronine sodium (JP18/USP)
D3D00401Methimazole (USP)
D4D00562Propylthiouracil (JP18/USP/INN)