KEGG   PATHWAY: aml04621
Entry
aml04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Ailuropoda melanoleuca (giant panda)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
aml04621  NOD-like receptor signaling pathway
aml04621

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100479663  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
100480506  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100466767  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100484109  IL18; interleukin-18 [KO:K05482]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100471563  TNF; tumor necrosis factor [KO:K03156]
100472054  CXCL8; interleukin-8 [KO:K10030]
100463732  growth-regulated alpha protein [KO:K05505]
100466241  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
100471490  growth-regulated alpha protein [KO:K05505]
100474348  C-C motif chemokine 2 [KO:K14624]
100463753  CCL5; C-C motif chemokine 5 [KO:K12499]
100476997  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
100465205  beta-defensin 103A [KO:K23126]
100469482  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
100466506  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100484077  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100468085  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100464125  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100463901  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
100474735  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100469708  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
100471461  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
100480510  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100480205  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
100468657  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100484167  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100477810  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
117803533  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
100481572  SUGT1; protein SGT1 homolog [KO:K12795]
105237977  LOW QUALITY PROTEIN: protein SGT1 homolog [KO:K12795]
100480605  SHARPIN; sharpin isoform X1 [KO:K20894]
100471387  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
100475726  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X3 [KO:K11974] [EC:2.3.2.31]
100471203  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100471523  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
100483035  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
100465494  ERBIN; erbin isoform X5 [KO:K12796]
100477152  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100477406  baculoviral IAP repeat-containing protein 2 [KO:K16060]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100475872  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100484878  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
100474270  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
100482674  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100466406  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100465112  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100484543  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100474086  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
100476812  interferon alpha-2 [KO:K05414]
100477312  interferon alpha-1/2 [KO:K05414]
100477562  LOW QUALITY PROTEIN: interferon alpha-1/2 [KO:K05414]
100478321  interferon alpha-1/2 [KO:K05414]
100478068  interferon alpha-like [KO:K05414]
100476556  IFNB1; interferon beta [KO:K05415]
100466950  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
100473412  ANTXR2; anthrax toxin receptor 2 isoform X2 [KO:K20909]
100478521  ANTXR1; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
100481297  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
100475582  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
100484344  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
100469922  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100476830  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100468792  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100482553  PANX1; pannexin-1 [KO:K03443]
100477277  P2RX7; P2X purinoceptor 7 isoform X2 [KO:K05220]
100479364  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
100482433  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100483855  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
100483630  CASR; extracellular calcium-sensing receptor [KO:K04612]
100476076  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100467161  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
100477888  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100471747  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100463625  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100465507  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100470763  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100475721  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100469118  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
100468112  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100469368  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
100469504  RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
100465111  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
100479787  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
100470367  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
100469872  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100465668  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X3 [KO:K08847] [EC:2.7.11.1]
100474116  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
100475373  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
100468223  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109490984  LOW QUALITY PROTEIN: dual oxidase 1 [KO:K21421] [EC:1.-.-.-]
100482979  cytochrome b-245 light chain isoform X3 [KO:K08009]
100464008  TXNIP; thioredoxin-interacting protein [KO:K20910]
100477286  TXN2; thioredoxin, mitochondrial isoform X2 [KO:K03671]
100477884  TXN; thioredoxin [KO:K03671]
109490451  thioredoxin [KO:K03671]
100464490  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
100475188  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X3 [KO:K11864] [EC:3.4.19.-]
100471414  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
100467363  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
117803466  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
100474378  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
100477362  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
100464289  immunity-related GTPase family M protein 1 isoform X1 [KO:K14139] [EC:3.6.5.-]
100463703  immunity-related GTPase family M protein 1-like isoform X1 [KO:K14139] [EC:3.6.5.-]
117801422  LOW QUALITY PROTEIN: immunity-related GTPase family M protein 1-like [KO:K14139] [EC:3.6.5.-]
100477997  MEFV; pyrin isoform X1 [KO:K12803]
100473221  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100465168  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
100469211  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
100465031  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
105236112  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
100464785  NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805]
100481918  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100469548  GBP5; guanylate-binding protein 5 isoform X1 [KO:K20898]
100475592  myeloid cell nuclear differentiation antigen-like protein isoform X1 [KO:K20914]
100468474  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100469677  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100466325  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100484851  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
100470311  guanylate-binding protein 4 [KO:K20899]
100465831  LOW QUALITY PROTEIN: guanylate-binding protein 1 [KO:K20899]
100470056  LOW QUALITY PROTEIN: guanylate-binding protein 6 [KO:K20899]
100464921  caspase-13 isoform X2 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100484366  GSDMD; gasdermin-D isoform X1 [KO:K20917]
100481921  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100482679  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100468422  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100474026  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100472167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100475480  IRF9; interferon regulatory factor 9 [KO:K04693]
100472815  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100463778  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100479307  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100469127  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100473848  STING1; stimulator of interferon genes protein isoform X2 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
aml04010  MAPK signaling pathway
aml04064  NF-kappa B signaling pathway
aml04140  Autophagy - animal
aml04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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