KEGG   PATHWAY: aju04024
Entry
aju04024                    Pathway                                
Name
cAMP signaling pathway - Acinonyx jubatus (cheetah)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
aju04024  cAMP signaling pathway
aju04024

Other DBs
GO: 0019933
Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106976261  VIP peptides isoform X1 [KO:K05264]
106979769  corticoliberin [KO:K05256]
106972533  glycoprotein hormones alpha chain [KO:K08522]
113593294  lutropin subunit beta [KO:K08521]
106971155  glycoprotein hormone alpha-2 [KO:K25483]
106971317  glycoprotein hormone beta-5 [KO:K25484]
106969661  thyrotropin subunit beta [KO:K05251]
106967900  pro-opiomelanocortin [KO:K05228]
106984562  pro-glucagon isoform X1 [KO:K05259]
106980493  gastric inhibitory polypeptide [KO:K05258]
106970268  follitropin subunit beta [KO:K05250]
106971865  natriuretic peptides A [KO:K12334]
106965762  pituitary adenylate cyclase-activating polypeptide isoform X2 [KO:K05262]
113600301  beta-1 adrenergic receptor [KO:K04141]
106981678  beta-2 adrenergic receptor [KO:K04142]
106975386  D(1A) dopamine receptor [KO:K04144]
106975633  D(1B) dopamine receptor [KO:K05840]
106979687  adenosine receptor A2a isoform X3 [KO:K04266]
106981675  5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
106983381  5-hydroxytryptamine receptor 6 [KO:K04162]
106981938  prostaglandin E2 receptor EP2 subtype [KO:K04259]
106968665  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2 [KO:K04587]
106980108  vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
106988835  corticotropin-releasing factor receptor 1 [KO:K04578]
106968685  corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
106977188  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
106983585  thyrotropin receptor isoform X1 [KO:K04249]
106979644  adrenocorticotropic hormone receptor [KO:K04200]
106972745  glucagon-like peptide 1 receptor [KO:K04581]
106973591  gastric inhibitory polypeptide receptor isoform X1 [KO:K04580]
106981568  glucose-dependent insulinotropic receptor [KO:K08424]
106977199  follicle-stimulating hormone receptor isoform X1 [KO:K04247]
106987270  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
106969942  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
106969924  neuroendocrine secretory protein 55 [KO:K04632]
106974187  endothelin-1 [KO:K16366]
106966971  endothelin-2 [KO:K16367]
106969938  endothelin-3 isoform X1 [KO:K05227]
106968038  somatostatin [KO:K05237]
106982832  pro-neuropeptide Y [KO:K05232]
106972375  appetite-regulating hormone isoform X1 [KO:K05254]
113602484  oxytocin-neurophysin 1 [KO:K05243]
113604790  5-hydroxytryptamine receptor 1F [KO:K04153]
106968882  5-hydroxytryptamine receptor 1A [KO:K04153]
106969793  5-hydroxytryptamine receptor 1B [KO:K04153]
106972532  5-hydroxytryptamine receptor 1E [KO:K04153]
106977648  5-hydroxytryptamine receptor 1D [KO:K04153]
106981762  muscarinic acetylcholine receptor M1 [KO:K04129]
106975696  muscarinic acetylcholine receptor M2 [KO:K04130]
106980600  D(2) dopamine receptor [KO:K04145]
106984038  gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
106981245  gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
106971862  adenosine receptor A1 [KO:K04265]
106983346  endothelin-1 receptor [KO:K04197]
106967457  neuropeptide Y receptor type 1 [KO:K04204]
106965501  somatostatin receptor type 1 isoform X1 [KO:K04217]
106978607  somatostatin receptor type 2 isoform X1 [KO:K04218]
106977345  somatostatin receptor type 5 [KO:K04221]
106967566  hydroxycarboxylic acid receptor 1 [KO:K08401]
106967564  hydroxycarboxylic acid receptor 2 [KO:K08402]
106974703  free fatty acid receptor 2 isoform X2 [KO:K04328]
106974684  LOW QUALITY PROTEIN: free fatty acid receptor 2-like [KO:K04328]
106975160  succinate receptor 1 [KO:K10042]
106982692  prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
106972335  oxytocin receptor [KO:K04229]
106990076  growth hormone secretagogue receptor type 1 [KO:K04284]
106977809  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
106982494  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106968223  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
106971248  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
106989109  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
106987869  adenylate cyclase type 4 isoform X5 [KO:K08044] [EC:4.6.1.1]
106984082  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106969297  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
106985835  adenylate cyclase type 7 isoform X4 [KO:K08047] [EC:4.6.1.1]
106976879  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
106978803  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
106966216  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
106985419  LOW QUALITY PROTEIN: adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
106975011  cGMP-gated cation channel alpha-1 [KO:K04948]
106988198  cyclic nucleotide-gated olfactory channel [KO:K04949]
106968724  cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
106981176  cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
106977011  cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
106977244  cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
106980445  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
106987911  calmodulin-1 [KO:K02183]
106977221  calmodulin-2 [KO:K02183]
106984637  calmodulin-like protein 6 isoform X1 [KO:K02183]
106973635  calmodulin-3 [KO:K02183]
106988136  calmodulin-like protein 3 [KO:K02183]
106988135  calmodulin-like [KO:K02183]
106977318  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
106968235  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
106970983  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
106985400  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
106975674  calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
106978888  blood vessel epicardial substance [KO:K21108]
106968280  popeye domain-containing protein 2 isoform X1 [KO:K26206]
106978887  popeye domain-containing protein 3 [KO:K26207]
106966794  potassium channel subfamily K member 2 isoform X2 [KO:K04913]
106978107  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
106979404  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
106984224  ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
106969310  rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
106987935  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
106983109  ras-related protein R-Ras isoform X1 [KO:K07829]
106971853  ras-related protein R-Ras2 isoform X2 [KO:K07830]
106990052  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
106972398  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
106965849  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
106969894  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106970668  mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
106989581  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106969628  ras-related protein Rap-1A isoform X1 [KO:K04353]
106966345  ras-related protein Rap-1b [KO:K07836]
106977842  rho guanine nucleotide exchange factor TIAM1 isoform X4 [KO:K05731]
106970805  proto-oncogene vav isoform X1 [KO:K05730]
106988256  guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
106974247  guanine nucleotide exchange factor VAV3 [KO:K05730]
106982604  ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
106981077  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
106986311  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
106976449  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
106968226  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
106979239  transforming protein RhoA [KO:K04513]
106978645  afadin isoform X1 [KO:K05702]
106984896  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106984265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106973880  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106976917  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106973297  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106969150  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106979622  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106975558  RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
106985046  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106970441  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
106977129  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106980282  dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
106975474  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106969232  mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
106990008  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106973352  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106985791  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
106980464  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
106967586  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106967920  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106971182  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106967098  cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
106981255  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
106970423  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
106987262  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
106975473  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
106978069  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
106987665  cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
106979918  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
106978741  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
106970278  LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
106974355  protein c-Fos [KO:K04379]
106974986  transcription factor Jun [KO:K04448]
106977751  transcriptional activator GLI3 isoform X3 [KO:K06230]
106975858  zinc finger protein GLI1 isoform X1 [KO:K16797]
106971452  protein patched homolog 1 isoform X2 [KO:K06225]
106983467  hedgehog-interacting protein isoform X1 [KO:K06231]
106965509  NF-kappa-B inhibitor alpha [KO:K04734]
106984704  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106971136  transcription factor p65 [KO:K04735]
106978610  transcription factor SOX-9 [KO:K18435]
113596341  muellerian-inhibiting factor [KO:K04665]
106967316  peroxisome proliferator-activated receptor alpha [KO:K07294]
106982705  peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
106987755  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
106977679  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
106981699  bcl2-associated agonist of cell death [KO:K02158]
106987707  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
106970030  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
106977263  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
106967400  protein phosphatase 1 regulatory subunit 12A isoform X6 [KO:K06270]
106979297  myosin regulatory light polypeptide 9 [KO:K12755]
106980877  troponin I, cardiac muscle [KO:K12044]
106968324  cardiac phospholamban [KO:K05852]
106966172  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
106987362  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
106967538  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
106987226  ryanodine receptor 2 isoform X5 [KO:K04962]
106989187  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
106989347  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
106965657  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
106987730  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
106986956  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
106972048  glutamate receptor ionotropic, NMDA 3A [KO:K05213]
113596369  glutamate receptor ionotropic, NMDA 3B isoform X2 [KO:K05214]
106967642  glutamate receptor 1 isoform X1 [KO:K05197]
106986586  glutamate receptor 2 isoform X3 [KO:K05198]
106972822  glutamate receptor 3 isoform X1 [KO:K05199]
106976499  glutamate receptor 4 isoform X1 [KO:K05200]
106970664  cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
106978517  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
106985576  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
106969643  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
106987698  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
106966210  sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
106981973  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
106986116  protein ATP1B4 isoform X1 [KO:K01540]
106972503  sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
106966269  sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538]
106974704  phospholemman [KO:K13360]
106977548  sodium/hydrogen exchanger 1 [KO:K05742]
106967590  calcium release-activated calcium channel protein 1 [KO:K16056]
106970793  plasma membrane calcium-transporting ATPase 4 isoform X3 [KO:K05850] [EC:7.2.2.10]
106978648  plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
106976608  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
106972378  plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
106965473  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
106986998  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106988999  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
106974264  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106977145  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
106989114  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
106976398  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9 [KO:K13293] [EC:3.1.4.53]
106980308  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
106969086  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
106984535  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
106985034  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
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